Risk factors for endometrial hyperplasia: Results from a case-control study

E. Ricci, S. Moroni, F. Parazzini, M. Surace, G. Benzi, B. Salerio, G. Polverino, C. La Vecchia

Research output: Contribution to journalArticle

Abstract

We analyzed epidemiologic characteristics of women at risk for endometrial hyperplasia (EH), using data from a case-control study. One hundred twenty nine women aged 35-73 (median 51 years) with histologically confirmed complex endometrial hyperplasia without atypies identified at the University of Milan during the period 1990-99 were examined. Controls were 258 non hysterectomized women aged 36-74 (median 52 years), admitted to a network of hospitals covering the same area where cases had been identified for conditions other than gynecological, malignant, or hormone-related. Cases with EH were more educated than controls (OR > 12 years of education vs. <7: 2.8, 95% CI 1.7-4.8), more frequently obese (OR 2.7, 95% CI 1.5-5.0) and diabetic (OR 2.4, 95% CI 0.8-6.9). Parous women (OR 1.8) and women reporting induced abortions (OR 1.6) showed an increased risk of EH, but the associations were not statistically significant. Compared to premenopausal women, the OR of EH was 0.2 (95% 0.1-0.5) for postmenopausal ones. Compared to women reporting menopause at age 50 or less, the OR of endometrial hyperplasia was 1.5 (95% CI 0.6-3.5) and 2.2 (95%CI 0.7-6.7), respectively, in women with menopause at age 50-52 and ≥ 53. Considering postmenopausal women only the OR was 3.1 (95% CI 1.1-9.3) for use of hormonal replacement therapy (HRT). We conclude that this study indicates that high education, obesity, diabetes, and HRT use increase the risk of endometrial hyperplasia.

Original languageEnglish
Pages (from-to)257-260
Number of pages4
JournalInternational Journal of Gynecological Cancer
Volume12
Issue number3
DOIs
Publication statusPublished - 2002

Fingerprint

Endometrial Hyperplasia
Case-Control Studies
Menopause
Education
Induced Abortion
Obesity
Hormones

Keywords

  • Endometrial hyperplasia
  • Epidemiology
  • Risk factor

ASJC Scopus subject areas

  • Cancer Research
  • Obstetrics and Gynaecology
  • Oncology

Cite this

Risk factors for endometrial hyperplasia : Results from a case-control study. / Ricci, E.; Moroni, S.; Parazzini, F.; Surace, M.; Benzi, G.; Salerio, B.; Polverino, G.; La Vecchia, C.

In: International Journal of Gynecological Cancer, Vol. 12, No. 3, 2002, p. 257-260.

Research output: Contribution to journalArticle

Ricci, E. ; Moroni, S. ; Parazzini, F. ; Surace, M. ; Benzi, G. ; Salerio, B. ; Polverino, G. ; La Vecchia, C. / Risk factors for endometrial hyperplasia : Results from a case-control study. In: International Journal of Gynecological Cancer. 2002 ; Vol. 12, No. 3. pp. 257-260.
@article{426572cd2bba4eb9addf8cc14f893449,
title = "Risk factors for endometrial hyperplasia: Results from a case-control study",
abstract = "We analyzed epidemiologic characteristics of women at risk for endometrial hyperplasia (EH), using data from a case-control study. One hundred twenty nine women aged 35-73 (median 51 years) with histologically confirmed complex endometrial hyperplasia without atypies identified at the University of Milan during the period 1990-99 were examined. Controls were 258 non hysterectomized women aged 36-74 (median 52 years), admitted to a network of hospitals covering the same area where cases had been identified for conditions other than gynecological, malignant, or hormone-related. Cases with EH were more educated than controls (OR > 12 years of education vs. <7: 2.8, 95{\%} CI 1.7-4.8), more frequently obese (OR 2.7, 95{\%} CI 1.5-5.0) and diabetic (OR 2.4, 95{\%} CI 0.8-6.9). Parous women (OR 1.8) and women reporting induced abortions (OR 1.6) showed an increased risk of EH, but the associations were not statistically significant. Compared to premenopausal women, the OR of EH was 0.2 (95{\%} 0.1-0.5) for postmenopausal ones. Compared to women reporting menopause at age 50 or less, the OR of endometrial hyperplasia was 1.5 (95{\%} CI 0.6-3.5) and 2.2 (95{\%}CI 0.7-6.7), respectively, in women with menopause at age 50-52 and ≥ 53. Considering postmenopausal women only the OR was 3.1 (95{\%} CI 1.1-9.3) for use of hormonal replacement therapy (HRT). We conclude that this study indicates that high education, obesity, diabetes, and HRT use increase the risk of endometrial hyperplasia.",
keywords = "Endometrial hyperplasia, Epidemiology, Risk factor",
author = "E. Ricci and S. Moroni and F. Parazzini and M. Surace and G. Benzi and B. Salerio and G. Polverino and {La Vecchia}, C.",
year = "2002",
doi = "10.1046/j.1525-1438.2002.01105.x",
language = "English",
volume = "12",
pages = "257--260",
journal = "International Journal of Gynecological Cancer",
issn = "1048-891X",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Risk factors for endometrial hyperplasia

T2 - Results from a case-control study

AU - Ricci, E.

AU - Moroni, S.

AU - Parazzini, F.

AU - Surace, M.

AU - Benzi, G.

AU - Salerio, B.

AU - Polverino, G.

AU - La Vecchia, C.

PY - 2002

Y1 - 2002

N2 - We analyzed epidemiologic characteristics of women at risk for endometrial hyperplasia (EH), using data from a case-control study. One hundred twenty nine women aged 35-73 (median 51 years) with histologically confirmed complex endometrial hyperplasia without atypies identified at the University of Milan during the period 1990-99 were examined. Controls were 258 non hysterectomized women aged 36-74 (median 52 years), admitted to a network of hospitals covering the same area where cases had been identified for conditions other than gynecological, malignant, or hormone-related. Cases with EH were more educated than controls (OR > 12 years of education vs. <7: 2.8, 95% CI 1.7-4.8), more frequently obese (OR 2.7, 95% CI 1.5-5.0) and diabetic (OR 2.4, 95% CI 0.8-6.9). Parous women (OR 1.8) and women reporting induced abortions (OR 1.6) showed an increased risk of EH, but the associations were not statistically significant. Compared to premenopausal women, the OR of EH was 0.2 (95% 0.1-0.5) for postmenopausal ones. Compared to women reporting menopause at age 50 or less, the OR of endometrial hyperplasia was 1.5 (95% CI 0.6-3.5) and 2.2 (95%CI 0.7-6.7), respectively, in women with menopause at age 50-52 and ≥ 53. Considering postmenopausal women only the OR was 3.1 (95% CI 1.1-9.3) for use of hormonal replacement therapy (HRT). We conclude that this study indicates that high education, obesity, diabetes, and HRT use increase the risk of endometrial hyperplasia.

AB - We analyzed epidemiologic characteristics of women at risk for endometrial hyperplasia (EH), using data from a case-control study. One hundred twenty nine women aged 35-73 (median 51 years) with histologically confirmed complex endometrial hyperplasia without atypies identified at the University of Milan during the period 1990-99 were examined. Controls were 258 non hysterectomized women aged 36-74 (median 52 years), admitted to a network of hospitals covering the same area where cases had been identified for conditions other than gynecological, malignant, or hormone-related. Cases with EH were more educated than controls (OR > 12 years of education vs. <7: 2.8, 95% CI 1.7-4.8), more frequently obese (OR 2.7, 95% CI 1.5-5.0) and diabetic (OR 2.4, 95% CI 0.8-6.9). Parous women (OR 1.8) and women reporting induced abortions (OR 1.6) showed an increased risk of EH, but the associations were not statistically significant. Compared to premenopausal women, the OR of EH was 0.2 (95% 0.1-0.5) for postmenopausal ones. Compared to women reporting menopause at age 50 or less, the OR of endometrial hyperplasia was 1.5 (95% CI 0.6-3.5) and 2.2 (95%CI 0.7-6.7), respectively, in women with menopause at age 50-52 and ≥ 53. Considering postmenopausal women only the OR was 3.1 (95% CI 1.1-9.3) for use of hormonal replacement therapy (HRT). We conclude that this study indicates that high education, obesity, diabetes, and HRT use increase the risk of endometrial hyperplasia.

KW - Endometrial hyperplasia

KW - Epidemiology

KW - Risk factor

UR - http://www.scopus.com/inward/record.url?scp=0036077623&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036077623&partnerID=8YFLogxK

U2 - 10.1046/j.1525-1438.2002.01105.x

DO - 10.1046/j.1525-1438.2002.01105.x

M3 - Article

C2 - 12060446

AN - SCOPUS:0036077623

VL - 12

SP - 257

EP - 260

JO - International Journal of Gynecological Cancer

JF - International Journal of Gynecological Cancer

SN - 1048-891X

IS - 3

ER -