Risk factors for first operation in Crohn's disease

G. Basilisco, M. Campanini, B. Cesana, T. Ranzi, P. Bianchi

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

We studied 267 consecutive Italian patients (146 male, 121 female) with Crohn's disease. Median time from the first symptom to diagnosis at our center was 21 months (range 1-372), whereas median follow-up from the first visit was 38 months (range 1-180). The disease affected the small bowel in 93 (35%) cases, the ileum and colon in 76 (28%), and in the colon in 98 (37%). Forty-nine percent of the patients underwent major abdominal surgery for the disease at least once. The cumulative probability of abdominal surgery was 36% and 55%, 60 and 120 months after the onset of symptoms, respectively. Univariate analysis indicated that patients with colon involvement (p <0.0001), those with a longer interval between first symptom and diagnosis (p <0.0001), and those at an older age at diagnosis (p <0.0003) had a significantly greater probability of escaping abdominal surgery. The interval between first symptom and diagnosis, the site of disease, and the age at diagnosis were confirmed as risk factors for surgery, in decreasing order of importance, by multivariate analysis with Cox's proportional hazard model. A prognostic index for first operation based on these variables is proposed.

Original languageEnglish
Pages (from-to)749-752
Number of pages4
JournalAmerican Journal of Gastroenterology
Volume84
Issue number7
Publication statusPublished - 1989

Fingerprint

Crohn Disease
Colon
Ileum
Proportional Hazards Models
Multivariate Analysis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Basilisco, G., Campanini, M., Cesana, B., Ranzi, T., & Bianchi, P. (1989). Risk factors for first operation in Crohn's disease. American Journal of Gastroenterology, 84(7), 749-752.

Risk factors for first operation in Crohn's disease. / Basilisco, G.; Campanini, M.; Cesana, B.; Ranzi, T.; Bianchi, P.

In: American Journal of Gastroenterology, Vol. 84, No. 7, 1989, p. 749-752.

Research output: Contribution to journalArticle

Basilisco, G, Campanini, M, Cesana, B, Ranzi, T & Bianchi, P 1989, 'Risk factors for first operation in Crohn's disease', American Journal of Gastroenterology, vol. 84, no. 7, pp. 749-752.
Basilisco G, Campanini M, Cesana B, Ranzi T, Bianchi P. Risk factors for first operation in Crohn's disease. American Journal of Gastroenterology. 1989;84(7):749-752.
Basilisco, G. ; Campanini, M. ; Cesana, B. ; Ranzi, T. ; Bianchi, P. / Risk factors for first operation in Crohn's disease. In: American Journal of Gastroenterology. 1989 ; Vol. 84, No. 7. pp. 749-752.
@article{2b97badb18404fb4b099636332f6e1c3,
title = "Risk factors for first operation in Crohn's disease",
abstract = "We studied 267 consecutive Italian patients (146 male, 121 female) with Crohn's disease. Median time from the first symptom to diagnosis at our center was 21 months (range 1-372), whereas median follow-up from the first visit was 38 months (range 1-180). The disease affected the small bowel in 93 (35{\%}) cases, the ileum and colon in 76 (28{\%}), and in the colon in 98 (37{\%}). Forty-nine percent of the patients underwent major abdominal surgery for the disease at least once. The cumulative probability of abdominal surgery was 36{\%} and 55{\%}, 60 and 120 months after the onset of symptoms, respectively. Univariate analysis indicated that patients with colon involvement (p <0.0001), those with a longer interval between first symptom and diagnosis (p <0.0001), and those at an older age at diagnosis (p <0.0003) had a significantly greater probability of escaping abdominal surgery. The interval between first symptom and diagnosis, the site of disease, and the age at diagnosis were confirmed as risk factors for surgery, in decreasing order of importance, by multivariate analysis with Cox's proportional hazard model. A prognostic index for first operation based on these variables is proposed.",
author = "G. Basilisco and M. Campanini and B. Cesana and T. Ranzi and P. Bianchi",
year = "1989",
language = "English",
volume = "84",
pages = "749--752",
journal = "American Journal of Gastroenterology",
issn = "0002-9270",
publisher = "Nature Publishing Group",
number = "7",

}

TY - JOUR

T1 - Risk factors for first operation in Crohn's disease

AU - Basilisco, G.

AU - Campanini, M.

AU - Cesana, B.

AU - Ranzi, T.

AU - Bianchi, P.

PY - 1989

Y1 - 1989

N2 - We studied 267 consecutive Italian patients (146 male, 121 female) with Crohn's disease. Median time from the first symptom to diagnosis at our center was 21 months (range 1-372), whereas median follow-up from the first visit was 38 months (range 1-180). The disease affected the small bowel in 93 (35%) cases, the ileum and colon in 76 (28%), and in the colon in 98 (37%). Forty-nine percent of the patients underwent major abdominal surgery for the disease at least once. The cumulative probability of abdominal surgery was 36% and 55%, 60 and 120 months after the onset of symptoms, respectively. Univariate analysis indicated that patients with colon involvement (p <0.0001), those with a longer interval between first symptom and diagnosis (p <0.0001), and those at an older age at diagnosis (p <0.0003) had a significantly greater probability of escaping abdominal surgery. The interval between first symptom and diagnosis, the site of disease, and the age at diagnosis were confirmed as risk factors for surgery, in decreasing order of importance, by multivariate analysis with Cox's proportional hazard model. A prognostic index for first operation based on these variables is proposed.

AB - We studied 267 consecutive Italian patients (146 male, 121 female) with Crohn's disease. Median time from the first symptom to diagnosis at our center was 21 months (range 1-372), whereas median follow-up from the first visit was 38 months (range 1-180). The disease affected the small bowel in 93 (35%) cases, the ileum and colon in 76 (28%), and in the colon in 98 (37%). Forty-nine percent of the patients underwent major abdominal surgery for the disease at least once. The cumulative probability of abdominal surgery was 36% and 55%, 60 and 120 months after the onset of symptoms, respectively. Univariate analysis indicated that patients with colon involvement (p <0.0001), those with a longer interval between first symptom and diagnosis (p <0.0001), and those at an older age at diagnosis (p <0.0003) had a significantly greater probability of escaping abdominal surgery. The interval between first symptom and diagnosis, the site of disease, and the age at diagnosis were confirmed as risk factors for surgery, in decreasing order of importance, by multivariate analysis with Cox's proportional hazard model. A prognostic index for first operation based on these variables is proposed.

UR - http://www.scopus.com/inward/record.url?scp=0024404981&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024404981&partnerID=8YFLogxK

M3 - Article

C2 - 2741884

AN - SCOPUS:0024404981

VL - 84

SP - 749

EP - 752

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

SN - 0002-9270

IS - 7

ER -