Risk factors for hepatitis C virus transmission to health care workers after occupational exposure: A European case-control study

Yazdan Yazdanpanah, G. De Carli, B. Migueres, F. Lot, M. Campins, C. Colombo, T. Thomas, S. Deuffic-Burban, M. H. Prevot, M. Domart, A. Tarantola, D. Abitehoul, P. Deny, S. Pol, J. C. Desenclos, V. Puro, E. Bouvet

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Background. Additional studies are required to identify risk factors for hepatitis C virus (HCV) transmission to health care workers after occupational exposure to HCV. Methods. We conducted a matched case-control study in 5 European countries from 1 January 1991 through 31 December 2002. Case patients were health care workers who experienced seroconversion after percutaneous or mucocutaneous exposure to HCV. Control subjects were HCV-exposed health care workers who did not experience seroconversion and were matched with case patients for center and period of exposure. Results. Sixty case patients and 204 control subjects were included in the study. All case patients were exposed to HCV-infected fluids through percutaneous injuries. The 37 case patients for whom information was available were exposed to viremic source patients. As risk factors for HCV infection, multivariate analysis identified needle placement in a source patient's vein or artery (odds ratio [OR], 100.1; 95% confidence interval [CI], 7.3-1365.7), deep injury (OR, 155.2; 95% CI, 7.1-3417.2), and sex of the health care worker (OR for male vs. female, 3.1; 95% CI, 1.0-10.0). Source patient HCV load was not introduced in the multivariate model. In unmatched univariate analysis, the risk of HCV transmission increased 11-fold for health care workers exposed to source patients with a viral load >6 log10 copies/mL (95% CI, 1.1-114.1), compared with exposures to source patients with a viral load ≤4 log10 copies/mL. Conclusion. In this study, HCV occupational transmission was found to occur after percutaneous exposures. The risk of HCV transmission after percutaneous exposure increased with deep injuries and procedures involving hollow-bore needle placement in the source patient's vein or artery. These results highlight the need for widespread adoption of needlestick-prevention devices in health care settings, together with other preventive measures.

Original languageEnglish
Pages (from-to)1423-1430
Number of pages8
JournalClinical Infectious Diseases
Volume41
Issue number10
DOIs
Publication statusPublished - Nov 15 2005

Fingerprint

Occupational Exposure
Hepacivirus
Case-Control Studies
Delivery of Health Care
Confidence Intervals
Odds Ratio
Viral Load
Needles
Veins
Wounds and Injuries
Arteries
Needlestick Injuries
Virus Diseases
Multivariate Analysis
Equipment and Supplies

ASJC Scopus subject areas

  • Immunology

Cite this

Risk factors for hepatitis C virus transmission to health care workers after occupational exposure : A European case-control study. / Yazdanpanah, Yazdan; De Carli, G.; Migueres, B.; Lot, F.; Campins, M.; Colombo, C.; Thomas, T.; Deuffic-Burban, S.; Prevot, M. H.; Domart, M.; Tarantola, A.; Abitehoul, D.; Deny, P.; Pol, S.; Desenclos, J. C.; Puro, V.; Bouvet, E.

In: Clinical Infectious Diseases, Vol. 41, No. 10, 15.11.2005, p. 1423-1430.

Research output: Contribution to journalArticle

Yazdanpanah, Y, De Carli, G, Migueres, B, Lot, F, Campins, M, Colombo, C, Thomas, T, Deuffic-Burban, S, Prevot, MH, Domart, M, Tarantola, A, Abitehoul, D, Deny, P, Pol, S, Desenclos, JC, Puro, V & Bouvet, E 2005, 'Risk factors for hepatitis C virus transmission to health care workers after occupational exposure: A European case-control study', Clinical Infectious Diseases, vol. 41, no. 10, pp. 1423-1430. https://doi.org/10.1086/497131
Yazdanpanah, Yazdan ; De Carli, G. ; Migueres, B. ; Lot, F. ; Campins, M. ; Colombo, C. ; Thomas, T. ; Deuffic-Burban, S. ; Prevot, M. H. ; Domart, M. ; Tarantola, A. ; Abitehoul, D. ; Deny, P. ; Pol, S. ; Desenclos, J. C. ; Puro, V. ; Bouvet, E. / Risk factors for hepatitis C virus transmission to health care workers after occupational exposure : A European case-control study. In: Clinical Infectious Diseases. 2005 ; Vol. 41, No. 10. pp. 1423-1430.
@article{b7fd35c4ef0c4f5bbb0b8da5efee55f2,
title = "Risk factors for hepatitis C virus transmission to health care workers after occupational exposure: A European case-control study",
abstract = "Background. Additional studies are required to identify risk factors for hepatitis C virus (HCV) transmission to health care workers after occupational exposure to HCV. Methods. We conducted a matched case-control study in 5 European countries from 1 January 1991 through 31 December 2002. Case patients were health care workers who experienced seroconversion after percutaneous or mucocutaneous exposure to HCV. Control subjects were HCV-exposed health care workers who did not experience seroconversion and were matched with case patients for center and period of exposure. Results. Sixty case patients and 204 control subjects were included in the study. All case patients were exposed to HCV-infected fluids through percutaneous injuries. The 37 case patients for whom information was available were exposed to viremic source patients. As risk factors for HCV infection, multivariate analysis identified needle placement in a source patient's vein or artery (odds ratio [OR], 100.1; 95{\%} confidence interval [CI], 7.3-1365.7), deep injury (OR, 155.2; 95{\%} CI, 7.1-3417.2), and sex of the health care worker (OR for male vs. female, 3.1; 95{\%} CI, 1.0-10.0). Source patient HCV load was not introduced in the multivariate model. In unmatched univariate analysis, the risk of HCV transmission increased 11-fold for health care workers exposed to source patients with a viral load >6 log10 copies/mL (95{\%} CI, 1.1-114.1), compared with exposures to source patients with a viral load ≤4 log10 copies/mL. Conclusion. In this study, HCV occupational transmission was found to occur after percutaneous exposures. The risk of HCV transmission after percutaneous exposure increased with deep injuries and procedures involving hollow-bore needle placement in the source patient's vein or artery. These results highlight the need for widespread adoption of needlestick-prevention devices in health care settings, together with other preventive measures.",
author = "Yazdan Yazdanpanah and {De Carli}, G. and B. Migueres and F. Lot and M. Campins and C. Colombo and T. Thomas and S. Deuffic-Burban and Prevot, {M. H.} and M. Domart and A. Tarantola and D. Abitehoul and P. Deny and S. Pol and Desenclos, {J. C.} and V. Puro and E. Bouvet",
year = "2005",
month = "11",
day = "15",
doi = "10.1086/497131",
language = "English",
volume = "41",
pages = "1423--1430",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "NLM (Medline)",
number = "10",

}

TY - JOUR

T1 - Risk factors for hepatitis C virus transmission to health care workers after occupational exposure

T2 - A European case-control study

AU - Yazdanpanah, Yazdan

AU - De Carli, G.

AU - Migueres, B.

AU - Lot, F.

AU - Campins, M.

AU - Colombo, C.

AU - Thomas, T.

AU - Deuffic-Burban, S.

AU - Prevot, M. H.

AU - Domart, M.

AU - Tarantola, A.

AU - Abitehoul, D.

AU - Deny, P.

AU - Pol, S.

AU - Desenclos, J. C.

AU - Puro, V.

AU - Bouvet, E.

PY - 2005/11/15

Y1 - 2005/11/15

N2 - Background. Additional studies are required to identify risk factors for hepatitis C virus (HCV) transmission to health care workers after occupational exposure to HCV. Methods. We conducted a matched case-control study in 5 European countries from 1 January 1991 through 31 December 2002. Case patients were health care workers who experienced seroconversion after percutaneous or mucocutaneous exposure to HCV. Control subjects were HCV-exposed health care workers who did not experience seroconversion and were matched with case patients for center and period of exposure. Results. Sixty case patients and 204 control subjects were included in the study. All case patients were exposed to HCV-infected fluids through percutaneous injuries. The 37 case patients for whom information was available were exposed to viremic source patients. As risk factors for HCV infection, multivariate analysis identified needle placement in a source patient's vein or artery (odds ratio [OR], 100.1; 95% confidence interval [CI], 7.3-1365.7), deep injury (OR, 155.2; 95% CI, 7.1-3417.2), and sex of the health care worker (OR for male vs. female, 3.1; 95% CI, 1.0-10.0). Source patient HCV load was not introduced in the multivariate model. In unmatched univariate analysis, the risk of HCV transmission increased 11-fold for health care workers exposed to source patients with a viral load >6 log10 copies/mL (95% CI, 1.1-114.1), compared with exposures to source patients with a viral load ≤4 log10 copies/mL. Conclusion. In this study, HCV occupational transmission was found to occur after percutaneous exposures. The risk of HCV transmission after percutaneous exposure increased with deep injuries and procedures involving hollow-bore needle placement in the source patient's vein or artery. These results highlight the need for widespread adoption of needlestick-prevention devices in health care settings, together with other preventive measures.

AB - Background. Additional studies are required to identify risk factors for hepatitis C virus (HCV) transmission to health care workers after occupational exposure to HCV. Methods. We conducted a matched case-control study in 5 European countries from 1 January 1991 through 31 December 2002. Case patients were health care workers who experienced seroconversion after percutaneous or mucocutaneous exposure to HCV. Control subjects were HCV-exposed health care workers who did not experience seroconversion and were matched with case patients for center and period of exposure. Results. Sixty case patients and 204 control subjects were included in the study. All case patients were exposed to HCV-infected fluids through percutaneous injuries. The 37 case patients for whom information was available were exposed to viremic source patients. As risk factors for HCV infection, multivariate analysis identified needle placement in a source patient's vein or artery (odds ratio [OR], 100.1; 95% confidence interval [CI], 7.3-1365.7), deep injury (OR, 155.2; 95% CI, 7.1-3417.2), and sex of the health care worker (OR for male vs. female, 3.1; 95% CI, 1.0-10.0). Source patient HCV load was not introduced in the multivariate model. In unmatched univariate analysis, the risk of HCV transmission increased 11-fold for health care workers exposed to source patients with a viral load >6 log10 copies/mL (95% CI, 1.1-114.1), compared with exposures to source patients with a viral load ≤4 log10 copies/mL. Conclusion. In this study, HCV occupational transmission was found to occur after percutaneous exposures. The risk of HCV transmission after percutaneous exposure increased with deep injuries and procedures involving hollow-bore needle placement in the source patient's vein or artery. These results highlight the need for widespread adoption of needlestick-prevention devices in health care settings, together with other preventive measures.

UR - http://www.scopus.com/inward/record.url?scp=27644489043&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27644489043&partnerID=8YFLogxK

U2 - 10.1086/497131

DO - 10.1086/497131

M3 - Article

C2 - 16231252

AN - SCOPUS:27644489043

VL - 41

SP - 1423

EP - 1430

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 10

ER -