Risk factors for HTLV-I and II in individuals attending a clinic for sexually transmitted diseases

Massimo Giuliani, Giovanni Rezza, Alessandro Cozzi Lepri, Aldo Di Carlo, Antonio Maini, Ercole Crescimbeni, Guido Palamara, Grazia Prignano, Federico Caprilli

Research output: Contribution to journalArticle

Abstract

Background: To date, few studies have provided information on risk factors for human t-lymphotropic viruses (HTLV) types I and II in European countries. In particular, few data are available from published studies conducted in STD centers. Goals: To identify risk factors for HTLV-I and HTLV-II infection and to better distinguish the epidemiologic patterns of the two viruses in Italy. Study Design: A cross-sectional study of individuals at high risk of sexually or parenterally transmitted infections attending a large STD center in an urban setting was conducted. Serologic tests for HTLV- I and II, HIV, hepatitis virus type B (HBV), hepatitis virus type C (HCV), and syphilis were performed. Information regarding at-risk behavior was collected using a specific questionnaire. Results: From January 1994 to June 1996, 1,457 individuals were recruited; of them, 1,016 (69.7%) were males, 1,051 (72.4%) Italians, and 288 (19.8%) non-Europeans. One thousand seventy- five (74.8%) participants were noninjecting-drug-using heterosexuals, 285 (19.6%) were men who have sex with men, and 97 (6.6%) were injecting drug users (IDU). The mean age of the study participants was 33.6 (±10.5) years. Nine (0.6%) individuals were positive for HTLV-I antibodies and 9 (0.6%) for HTLV-II antibodies. The prevalence of HTLV-I among IDUs, men who have sex with men, and non-injecting-drug-using heterosexuals, was 2.1% (2/97), 1.4% (4/285), and 0.3% (3/1085), respectively. HTLV-II prevalence was 8.2% (8/97) among IDUs and 0.09% (1/1075) among noninjecting-drug-using heterosexuals. Among the nine HTLV-II-positive individuals, eight were Italian IDUs and one was a noninjecting-drug-using heterosexual man from India. None of the 285 men who have sex with men had HTLV-II antibodies. HTLV-infected individuals tended to be older than those who were uninfected. HTLV-I-infected individuals were more likely to be non-European and to have antibodies against Treponema pallidum. Injecting drug use tended to be independently associated with HTLV-II infection. Conclusions: The data suggest a role of sexual behavior in the spread of HTLV-I, which is more likely to be detected in individuals coming from endemic areas. Injecting drug use remains the most important risk factor for HTLV-II infection in Italy.

Original languageEnglish
Pages (from-to)87-90
Number of pages4
JournalSexually Transmitted Diseases
Volume27
Issue number2
Publication statusPublished - Feb 2000

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Sexually Transmitted Diseases
Viruses
Heterosexuality
Virus Diseases
Pharmaceutical Preparations
Antibodies
Italy
Treponema pallidum
Serologic Tests
Syphilis
Risk-Taking
Drug Users
Hepatitis B virus
Sexual Behavior
Hepacivirus
India

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)

Cite this

Giuliani, M., Rezza, G., Lepri, A. C., Di Carlo, A., Maini, A., Crescimbeni, E., ... Caprilli, F. (2000). Risk factors for HTLV-I and II in individuals attending a clinic for sexually transmitted diseases. Sexually Transmitted Diseases, 27(2), 87-90.

Risk factors for HTLV-I and II in individuals attending a clinic for sexually transmitted diseases. / Giuliani, Massimo; Rezza, Giovanni; Lepri, Alessandro Cozzi; Di Carlo, Aldo; Maini, Antonio; Crescimbeni, Ercole; Palamara, Guido; Prignano, Grazia; Caprilli, Federico.

In: Sexually Transmitted Diseases, Vol. 27, No. 2, 02.2000, p. 87-90.

Research output: Contribution to journalArticle

Giuliani, M, Rezza, G, Lepri, AC, Di Carlo, A, Maini, A, Crescimbeni, E, Palamara, G, Prignano, G & Caprilli, F 2000, 'Risk factors for HTLV-I and II in individuals attending a clinic for sexually transmitted diseases', Sexually Transmitted Diseases, vol. 27, no. 2, pp. 87-90.
Giuliani M, Rezza G, Lepri AC, Di Carlo A, Maini A, Crescimbeni E et al. Risk factors for HTLV-I and II in individuals attending a clinic for sexually transmitted diseases. Sexually Transmitted Diseases. 2000 Feb;27(2):87-90.
Giuliani, Massimo ; Rezza, Giovanni ; Lepri, Alessandro Cozzi ; Di Carlo, Aldo ; Maini, Antonio ; Crescimbeni, Ercole ; Palamara, Guido ; Prignano, Grazia ; Caprilli, Federico. / Risk factors for HTLV-I and II in individuals attending a clinic for sexually transmitted diseases. In: Sexually Transmitted Diseases. 2000 ; Vol. 27, No. 2. pp. 87-90.
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abstract = "Background: To date, few studies have provided information on risk factors for human t-lymphotropic viruses (HTLV) types I and II in European countries. In particular, few data are available from published studies conducted in STD centers. Goals: To identify risk factors for HTLV-I and HTLV-II infection and to better distinguish the epidemiologic patterns of the two viruses in Italy. Study Design: A cross-sectional study of individuals at high risk of sexually or parenterally transmitted infections attending a large STD center in an urban setting was conducted. Serologic tests for HTLV- I and II, HIV, hepatitis virus type B (HBV), hepatitis virus type C (HCV), and syphilis were performed. Information regarding at-risk behavior was collected using a specific questionnaire. Results: From January 1994 to June 1996, 1,457 individuals were recruited; of them, 1,016 (69.7{\%}) were males, 1,051 (72.4{\%}) Italians, and 288 (19.8{\%}) non-Europeans. One thousand seventy- five (74.8{\%}) participants were noninjecting-drug-using heterosexuals, 285 (19.6{\%}) were men who have sex with men, and 97 (6.6{\%}) were injecting drug users (IDU). The mean age of the study participants was 33.6 (±10.5) years. Nine (0.6{\%}) individuals were positive for HTLV-I antibodies and 9 (0.6{\%}) for HTLV-II antibodies. The prevalence of HTLV-I among IDUs, men who have sex with men, and non-injecting-drug-using heterosexuals, was 2.1{\%} (2/97), 1.4{\%} (4/285), and 0.3{\%} (3/1085), respectively. HTLV-II prevalence was 8.2{\%} (8/97) among IDUs and 0.09{\%} (1/1075) among noninjecting-drug-using heterosexuals. Among the nine HTLV-II-positive individuals, eight were Italian IDUs and one was a noninjecting-drug-using heterosexual man from India. None of the 285 men who have sex with men had HTLV-II antibodies. HTLV-infected individuals tended to be older than those who were uninfected. HTLV-I-infected individuals were more likely to be non-European and to have antibodies against Treponema pallidum. Injecting drug use tended to be independently associated with HTLV-II infection. Conclusions: The data suggest a role of sexual behavior in the spread of HTLV-I, which is more likely to be detected in individuals coming from endemic areas. Injecting drug use remains the most important risk factor for HTLV-II infection in Italy.",
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AU - Giuliani, Massimo

AU - Rezza, Giovanni

AU - Lepri, Alessandro Cozzi

AU - Di Carlo, Aldo

AU - Maini, Antonio

AU - Crescimbeni, Ercole

AU - Palamara, Guido

AU - Prignano, Grazia

AU - Caprilli, Federico

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N2 - Background: To date, few studies have provided information on risk factors for human t-lymphotropic viruses (HTLV) types I and II in European countries. In particular, few data are available from published studies conducted in STD centers. Goals: To identify risk factors for HTLV-I and HTLV-II infection and to better distinguish the epidemiologic patterns of the two viruses in Italy. Study Design: A cross-sectional study of individuals at high risk of sexually or parenterally transmitted infections attending a large STD center in an urban setting was conducted. Serologic tests for HTLV- I and II, HIV, hepatitis virus type B (HBV), hepatitis virus type C (HCV), and syphilis were performed. Information regarding at-risk behavior was collected using a specific questionnaire. Results: From January 1994 to June 1996, 1,457 individuals were recruited; of them, 1,016 (69.7%) were males, 1,051 (72.4%) Italians, and 288 (19.8%) non-Europeans. One thousand seventy- five (74.8%) participants were noninjecting-drug-using heterosexuals, 285 (19.6%) were men who have sex with men, and 97 (6.6%) were injecting drug users (IDU). The mean age of the study participants was 33.6 (±10.5) years. Nine (0.6%) individuals were positive for HTLV-I antibodies and 9 (0.6%) for HTLV-II antibodies. The prevalence of HTLV-I among IDUs, men who have sex with men, and non-injecting-drug-using heterosexuals, was 2.1% (2/97), 1.4% (4/285), and 0.3% (3/1085), respectively. HTLV-II prevalence was 8.2% (8/97) among IDUs and 0.09% (1/1075) among noninjecting-drug-using heterosexuals. Among the nine HTLV-II-positive individuals, eight were Italian IDUs and one was a noninjecting-drug-using heterosexual man from India. None of the 285 men who have sex with men had HTLV-II antibodies. HTLV-infected individuals tended to be older than those who were uninfected. HTLV-I-infected individuals were more likely to be non-European and to have antibodies against Treponema pallidum. Injecting drug use tended to be independently associated with HTLV-II infection. Conclusions: The data suggest a role of sexual behavior in the spread of HTLV-I, which is more likely to be detected in individuals coming from endemic areas. Injecting drug use remains the most important risk factor for HTLV-II infection in Italy.

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