Abstract
OBJECTIVES:To investigate environmental, personal, and hereditary risk factors associated with the occurrence of intraductal papillary mucinous neoplasms of the pancreas (IPMNs).METHODS:Multicentre case-control study. Risk factors were identified from a questionnaire collecting data on family and medical history, and environmental factors. Cases were prevalent IPMNs seen at the participating units within an 18-month timeframe. Matched controls were enrolled alongside patients seen at outpatient clinics.RESULTS:Three-hundred and ninety patients with IPMN and 390 matched controls (166 males, mean age 65 in each group) were enrolled. Of the IPMNs, 310 had branch-duct involvement and 80 main-duct involvement. The only cancer with a 1st degree family history significantly higher in IPMN was pancreatic ductal adenocarcinoma (PDAC) (5.4% vs. 1.5%). Previous history of diabetes (13.6% vs. 7.5%), chronic pancreatitis (CP) (3.1% vs. 0.3%), peptic ulcer (7.2% vs. 4.3%), and insulin use (4.9% vs. 1.1%) were all more frequent with IPMNs. Logistic regression multivariate analysis revealed that history of diabetes (odds ratio (OR): 1.79, confidence interval (CI) 95%: 1.08-2.98), CP (OR: 10.10, CI 95%: 1.30-78.32), and family histories of PDAC (OR: 2.94, CI 95%: 1.17-7.39) were all independent risk factors. However, when analysis was restricted to diabetics who had taken insulin, risk of IPMN became stronger (OR: 6.03, CI 95%: 1.74-20.84). The association with all these risk factors seemed stronger for the subgroup with main duct involvement.CONCLUSIONS:A previous history of diabetes, especially with insulin use, CP, and family history of PDAC are all relevant risk factors for the development of IPMN. These results suggest an overlap between certain risk factors for PDAC and IPMN.
| Original language | English |
|---|---|
| Pages (from-to) | 1003-1009 |
| Number of pages | 7 |
| Journal | American Journal of Gastroenterology |
| Volume | 108 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2013 |
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ASJC Scopus subject areas
- Gastroenterology
Cite this
Risk factors for intraductal papillary mucinous neoplasm (ipmn) of the pancreas : A multicentre case-control study. / Capurso, Gabriele; Boccia, Stefania; Salvia, Roberto; Del Chiaro, Marco; Frulloni, Luca; Arcidiacono, Paolo Giorgio; Zerbi, Alessandro; Manta, Raffaele; Fabbri, Carlo; Ventrucci, Maurizio; Tarantino, Ilaria; Piciucchi, Matteo; Carnuccio, Antonella; Boggi, Ugo; Leoncini, Emanuele; Costamagna, Guido; Delle Fave, Gianfranco; Pezzilli, Raffaele; Bassi, Claudio; Larghi, Alberto.
In: American Journal of Gastroenterology, Vol. 108, No. 6, 06.2013, p. 1003-1009.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Risk factors for intraductal papillary mucinous neoplasm (ipmn) of the pancreas
T2 - A multicentre case-control study
AU - Capurso, Gabriele
AU - Boccia, Stefania
AU - Salvia, Roberto
AU - Del Chiaro, Marco
AU - Frulloni, Luca
AU - Arcidiacono, Paolo Giorgio
AU - Zerbi, Alessandro
AU - Manta, Raffaele
AU - Fabbri, Carlo
AU - Ventrucci, Maurizio
AU - Tarantino, Ilaria
AU - Piciucchi, Matteo
AU - Carnuccio, Antonella
AU - Boggi, Ugo
AU - Leoncini, Emanuele
AU - Costamagna, Guido
AU - Delle Fave, Gianfranco
AU - Pezzilli, Raffaele
AU - Bassi, Claudio
AU - Larghi, Alberto
PY - 2013/6
Y1 - 2013/6
N2 - OBJECTIVES:To investigate environmental, personal, and hereditary risk factors associated with the occurrence of intraductal papillary mucinous neoplasms of the pancreas (IPMNs).METHODS:Multicentre case-control study. Risk factors were identified from a questionnaire collecting data on family and medical history, and environmental factors. Cases were prevalent IPMNs seen at the participating units within an 18-month timeframe. Matched controls were enrolled alongside patients seen at outpatient clinics.RESULTS:Three-hundred and ninety patients with IPMN and 390 matched controls (166 males, mean age 65 in each group) were enrolled. Of the IPMNs, 310 had branch-duct involvement and 80 main-duct involvement. The only cancer with a 1st degree family history significantly higher in IPMN was pancreatic ductal adenocarcinoma (PDAC) (5.4% vs. 1.5%). Previous history of diabetes (13.6% vs. 7.5%), chronic pancreatitis (CP) (3.1% vs. 0.3%), peptic ulcer (7.2% vs. 4.3%), and insulin use (4.9% vs. 1.1%) were all more frequent with IPMNs. Logistic regression multivariate analysis revealed that history of diabetes (odds ratio (OR): 1.79, confidence interval (CI) 95%: 1.08-2.98), CP (OR: 10.10, CI 95%: 1.30-78.32), and family histories of PDAC (OR: 2.94, CI 95%: 1.17-7.39) were all independent risk factors. However, when analysis was restricted to diabetics who had taken insulin, risk of IPMN became stronger (OR: 6.03, CI 95%: 1.74-20.84). The association with all these risk factors seemed stronger for the subgroup with main duct involvement.CONCLUSIONS:A previous history of diabetes, especially with insulin use, CP, and family history of PDAC are all relevant risk factors for the development of IPMN. These results suggest an overlap between certain risk factors for PDAC and IPMN.
AB - OBJECTIVES:To investigate environmental, personal, and hereditary risk factors associated with the occurrence of intraductal papillary mucinous neoplasms of the pancreas (IPMNs).METHODS:Multicentre case-control study. Risk factors were identified from a questionnaire collecting data on family and medical history, and environmental factors. Cases were prevalent IPMNs seen at the participating units within an 18-month timeframe. Matched controls were enrolled alongside patients seen at outpatient clinics.RESULTS:Three-hundred and ninety patients with IPMN and 390 matched controls (166 males, mean age 65 in each group) were enrolled. Of the IPMNs, 310 had branch-duct involvement and 80 main-duct involvement. The only cancer with a 1st degree family history significantly higher in IPMN was pancreatic ductal adenocarcinoma (PDAC) (5.4% vs. 1.5%). Previous history of diabetes (13.6% vs. 7.5%), chronic pancreatitis (CP) (3.1% vs. 0.3%), peptic ulcer (7.2% vs. 4.3%), and insulin use (4.9% vs. 1.1%) were all more frequent with IPMNs. Logistic regression multivariate analysis revealed that history of diabetes (odds ratio (OR): 1.79, confidence interval (CI) 95%: 1.08-2.98), CP (OR: 10.10, CI 95%: 1.30-78.32), and family histories of PDAC (OR: 2.94, CI 95%: 1.17-7.39) were all independent risk factors. However, when analysis was restricted to diabetics who had taken insulin, risk of IPMN became stronger (OR: 6.03, CI 95%: 1.74-20.84). The association with all these risk factors seemed stronger for the subgroup with main duct involvement.CONCLUSIONS:A previous history of diabetes, especially with insulin use, CP, and family history of PDAC are all relevant risk factors for the development of IPMN. These results suggest an overlap between certain risk factors for PDAC and IPMN.
UR - http://www.scopus.com/inward/record.url?scp=84878909222&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878909222&partnerID=8YFLogxK
U2 - 10.1038/ajg.2013.42
DO - 10.1038/ajg.2013.42
M3 - Article
C2 - 23458848
AN - SCOPUS:84878909222
VL - 108
SP - 1003
EP - 1009
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
SN - 0002-9270
IS - 6
ER -