Risk factors for intraductal papillary mucinous neoplasm (ipmn) of the pancreas: A multicentre case-control study

Gabriele Capurso, Stefania Boccia, Roberto Salvia, Marco Del Chiaro, Luca Frulloni, Paolo Giorgio Arcidiacono, Alessandro Zerbi, Raffaele Manta, Carlo Fabbri, Maurizio Ventrucci, Ilaria Tarantino, Matteo Piciucchi, Antonella Carnuccio, Ugo Boggi, Emanuele Leoncini, Guido Costamagna, Gianfranco Delle Fave, Raffaele Pezzilli, Claudio Bassi, Alberto Larghi

Research output: Contribution to journalArticle

Abstract

OBJECTIVES:To investigate environmental, personal, and hereditary risk factors associated with the occurrence of intraductal papillary mucinous neoplasms of the pancreas (IPMNs).METHODS:Multicentre case-control study. Risk factors were identified from a questionnaire collecting data on family and medical history, and environmental factors. Cases were prevalent IPMNs seen at the participating units within an 18-month timeframe. Matched controls were enrolled alongside patients seen at outpatient clinics.RESULTS:Three-hundred and ninety patients with IPMN and 390 matched controls (166 males, mean age 65 in each group) were enrolled. Of the IPMNs, 310 had branch-duct involvement and 80 main-duct involvement. The only cancer with a 1st degree family history significantly higher in IPMN was pancreatic ductal adenocarcinoma (PDAC) (5.4% vs. 1.5%). Previous history of diabetes (13.6% vs. 7.5%), chronic pancreatitis (CP) (3.1% vs. 0.3%), peptic ulcer (7.2% vs. 4.3%), and insulin use (4.9% vs. 1.1%) were all more frequent with IPMNs. Logistic regression multivariate analysis revealed that history of diabetes (odds ratio (OR): 1.79, confidence interval (CI) 95%: 1.08-2.98), CP (OR: 10.10, CI 95%: 1.30-78.32), and family histories of PDAC (OR: 2.94, CI 95%: 1.17-7.39) were all independent risk factors. However, when analysis was restricted to diabetics who had taken insulin, risk of IPMN became stronger (OR: 6.03, CI 95%: 1.74-20.84). The association with all these risk factors seemed stronger for the subgroup with main duct involvement.CONCLUSIONS:A previous history of diabetes, especially with insulin use, CP, and family history of PDAC are all relevant risk factors for the development of IPMN. These results suggest an overlap between certain risk factors for PDAC and IPMN.

Original languageEnglish
Pages (from-to)1003-1009
Number of pages7
JournalAmerican Journal of Gastroenterology
Volume108
Issue number6
DOIs
Publication statusPublished - Jun 2013

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Pancreatic Neoplasms
Case-Control Studies
Chronic Pancreatitis
Odds Ratio
Confidence Intervals
Adenocarcinoma
Insulin
Medical History Taking
Papillary Adenocarcinoma
Ambulatory Care Facilities
Peptic Ulcer
Multivariate Analysis
Logistic Models
Regression Analysis

ASJC Scopus subject areas

  • Gastroenterology

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Risk factors for intraductal papillary mucinous neoplasm (ipmn) of the pancreas : A multicentre case-control study. / Capurso, Gabriele; Boccia, Stefania; Salvia, Roberto; Del Chiaro, Marco; Frulloni, Luca; Arcidiacono, Paolo Giorgio; Zerbi, Alessandro; Manta, Raffaele; Fabbri, Carlo; Ventrucci, Maurizio; Tarantino, Ilaria; Piciucchi, Matteo; Carnuccio, Antonella; Boggi, Ugo; Leoncini, Emanuele; Costamagna, Guido; Delle Fave, Gianfranco; Pezzilli, Raffaele; Bassi, Claudio; Larghi, Alberto.

In: American Journal of Gastroenterology, Vol. 108, No. 6, 06.2013, p. 1003-1009.

Research output: Contribution to journalArticle

Capurso, G, Boccia, S, Salvia, R, Del Chiaro, M, Frulloni, L, Arcidiacono, PG, Zerbi, A, Manta, R, Fabbri, C, Ventrucci, M, Tarantino, I, Piciucchi, M, Carnuccio, A, Boggi, U, Leoncini, E, Costamagna, G, Delle Fave, G, Pezzilli, R, Bassi, C & Larghi, A 2013, 'Risk factors for intraductal papillary mucinous neoplasm (ipmn) of the pancreas: A multicentre case-control study', American Journal of Gastroenterology, vol. 108, no. 6, pp. 1003-1009. https://doi.org/10.1038/ajg.2013.42
Capurso, Gabriele ; Boccia, Stefania ; Salvia, Roberto ; Del Chiaro, Marco ; Frulloni, Luca ; Arcidiacono, Paolo Giorgio ; Zerbi, Alessandro ; Manta, Raffaele ; Fabbri, Carlo ; Ventrucci, Maurizio ; Tarantino, Ilaria ; Piciucchi, Matteo ; Carnuccio, Antonella ; Boggi, Ugo ; Leoncini, Emanuele ; Costamagna, Guido ; Delle Fave, Gianfranco ; Pezzilli, Raffaele ; Bassi, Claudio ; Larghi, Alberto. / Risk factors for intraductal papillary mucinous neoplasm (ipmn) of the pancreas : A multicentre case-control study. In: American Journal of Gastroenterology. 2013 ; Vol. 108, No. 6. pp. 1003-1009.
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abstract = "OBJECTIVES:To investigate environmental, personal, and hereditary risk factors associated with the occurrence of intraductal papillary mucinous neoplasms of the pancreas (IPMNs).METHODS:Multicentre case-control study. Risk factors were identified from a questionnaire collecting data on family and medical history, and environmental factors. Cases were prevalent IPMNs seen at the participating units within an 18-month timeframe. Matched controls were enrolled alongside patients seen at outpatient clinics.RESULTS:Three-hundred and ninety patients with IPMN and 390 matched controls (166 males, mean age 65 in each group) were enrolled. Of the IPMNs, 310 had branch-duct involvement and 80 main-duct involvement. The only cancer with a 1st degree family history significantly higher in IPMN was pancreatic ductal adenocarcinoma (PDAC) (5.4{\%} vs. 1.5{\%}). Previous history of diabetes (13.6{\%} vs. 7.5{\%}), chronic pancreatitis (CP) (3.1{\%} vs. 0.3{\%}), peptic ulcer (7.2{\%} vs. 4.3{\%}), and insulin use (4.9{\%} vs. 1.1{\%}) were all more frequent with IPMNs. Logistic regression multivariate analysis revealed that history of diabetes (odds ratio (OR): 1.79, confidence interval (CI) 95{\%}: 1.08-2.98), CP (OR: 10.10, CI 95{\%}: 1.30-78.32), and family histories of PDAC (OR: 2.94, CI 95{\%}: 1.17-7.39) were all independent risk factors. However, when analysis was restricted to diabetics who had taken insulin, risk of IPMN became stronger (OR: 6.03, CI 95{\%}: 1.74-20.84). The association with all these risk factors seemed stronger for the subgroup with main duct involvement.CONCLUSIONS:A previous history of diabetes, especially with insulin use, CP, and family history of PDAC are all relevant risk factors for the development of IPMN. These results suggest an overlap between certain risk factors for PDAC and IPMN.",
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T1 - Risk factors for intraductal papillary mucinous neoplasm (ipmn) of the pancreas

T2 - A multicentre case-control study

AU - Capurso, Gabriele

AU - Boccia, Stefania

AU - Salvia, Roberto

AU - Del Chiaro, Marco

AU - Frulloni, Luca

AU - Arcidiacono, Paolo Giorgio

AU - Zerbi, Alessandro

AU - Manta, Raffaele

AU - Fabbri, Carlo

AU - Ventrucci, Maurizio

AU - Tarantino, Ilaria

AU - Piciucchi, Matteo

AU - Carnuccio, Antonella

AU - Boggi, Ugo

AU - Leoncini, Emanuele

AU - Costamagna, Guido

AU - Delle Fave, Gianfranco

AU - Pezzilli, Raffaele

AU - Bassi, Claudio

AU - Larghi, Alberto

PY - 2013/6

Y1 - 2013/6

N2 - OBJECTIVES:To investigate environmental, personal, and hereditary risk factors associated with the occurrence of intraductal papillary mucinous neoplasms of the pancreas (IPMNs).METHODS:Multicentre case-control study. Risk factors were identified from a questionnaire collecting data on family and medical history, and environmental factors. Cases were prevalent IPMNs seen at the participating units within an 18-month timeframe. Matched controls were enrolled alongside patients seen at outpatient clinics.RESULTS:Three-hundred and ninety patients with IPMN and 390 matched controls (166 males, mean age 65 in each group) were enrolled. Of the IPMNs, 310 had branch-duct involvement and 80 main-duct involvement. The only cancer with a 1st degree family history significantly higher in IPMN was pancreatic ductal adenocarcinoma (PDAC) (5.4% vs. 1.5%). Previous history of diabetes (13.6% vs. 7.5%), chronic pancreatitis (CP) (3.1% vs. 0.3%), peptic ulcer (7.2% vs. 4.3%), and insulin use (4.9% vs. 1.1%) were all more frequent with IPMNs. Logistic regression multivariate analysis revealed that history of diabetes (odds ratio (OR): 1.79, confidence interval (CI) 95%: 1.08-2.98), CP (OR: 10.10, CI 95%: 1.30-78.32), and family histories of PDAC (OR: 2.94, CI 95%: 1.17-7.39) were all independent risk factors. However, when analysis was restricted to diabetics who had taken insulin, risk of IPMN became stronger (OR: 6.03, CI 95%: 1.74-20.84). The association with all these risk factors seemed stronger for the subgroup with main duct involvement.CONCLUSIONS:A previous history of diabetes, especially with insulin use, CP, and family history of PDAC are all relevant risk factors for the development of IPMN. These results suggest an overlap between certain risk factors for PDAC and IPMN.

AB - OBJECTIVES:To investigate environmental, personal, and hereditary risk factors associated with the occurrence of intraductal papillary mucinous neoplasms of the pancreas (IPMNs).METHODS:Multicentre case-control study. Risk factors were identified from a questionnaire collecting data on family and medical history, and environmental factors. Cases were prevalent IPMNs seen at the participating units within an 18-month timeframe. Matched controls were enrolled alongside patients seen at outpatient clinics.RESULTS:Three-hundred and ninety patients with IPMN and 390 matched controls (166 males, mean age 65 in each group) were enrolled. Of the IPMNs, 310 had branch-duct involvement and 80 main-duct involvement. The only cancer with a 1st degree family history significantly higher in IPMN was pancreatic ductal adenocarcinoma (PDAC) (5.4% vs. 1.5%). Previous history of diabetes (13.6% vs. 7.5%), chronic pancreatitis (CP) (3.1% vs. 0.3%), peptic ulcer (7.2% vs. 4.3%), and insulin use (4.9% vs. 1.1%) were all more frequent with IPMNs. Logistic regression multivariate analysis revealed that history of diabetes (odds ratio (OR): 1.79, confidence interval (CI) 95%: 1.08-2.98), CP (OR: 10.10, CI 95%: 1.30-78.32), and family histories of PDAC (OR: 2.94, CI 95%: 1.17-7.39) were all independent risk factors. However, when analysis was restricted to diabetics who had taken insulin, risk of IPMN became stronger (OR: 6.03, CI 95%: 1.74-20.84). The association with all these risk factors seemed stronger for the subgroup with main duct involvement.CONCLUSIONS:A previous history of diabetes, especially with insulin use, CP, and family history of PDAC are all relevant risk factors for the development of IPMN. These results suggest an overlap between certain risk factors for PDAC and IPMN.

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