Risk factors for locally advanced cancer associated with ulcerative colitis: Results of a retrospective multicentric study in the era of biologics

Matteo Rottoli, Marta Tanzanu, Francesca Di Candido, Francesco Colombo, Alice Frontali, Pramodh C Chandrasinghe, Gianluca Pellino, Matteo Frasson, Janindra Warusavitarne, Yves Panis, Gianluca M Sampietro, Antonino Spinelli, Gilberto Poggioli

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Patients affected by ulcerative colitis (UC) are more likely to develop colorectal cancer, and are often diagnosed with lymph node involvement (N+) at surgery.

AIM: To identify the risk factors for N+ cancer in UC patients.

METHODS: Patients undergoing surgery from 2001 to 2018 in six European tertiary centres were included. N+ patients were compared to the control group (N-) for clinical variables. The evaluation of risk factors for N+ was assessed using univariate and multivariable logistic regression analyses.

RESULTS: A total of 130 patients were included. Median duration of disease was 21 years (1-52). Forty patients (30.8%) were N+ at surgery. Eighteen (13.8%) developed cancer within 10 years from the onset of UC. Younger age at surgery (Odds ratio -OR- 0.96, p = 0.042), left colon location (OR 2.44, p = 0.045) and the presence of stricture (OR 5.07, p = 0.002) were associated with N+.

CONCLUSION: Location in the left colon, presence of strictures and younger age strongly correlated with a higher risk of N+ cancer, which could develop before the starting point of surveillance. Duration, extension and severity of disease were not associated with N+. These results should be considered in the evaluation of risk of advanced cancer in UC patients.

Original languageEnglish
Pages (from-to)33-37
Number of pages5
JournalDigestive and Liver Disease
Volume52
Issue number1
DOIs
Publication statusPublished - Jan 2020

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