Risk factors for locally advanced cancer associated with ulcerative colitis: Results of a retrospective multicentric study in the era of biologics

Matteo Rottoli, Marta Tanzanu, Francesca Di Candido, Francesco Colombo, Alice Frontali, Pramodh C Chandrasinghe, Gianluca Pellino, Matteo Frasson, Janindra Warusavitarne, Yves Panis, Gianluca M Sampietro, Antonino Spinelli, Gilberto Poggioli

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Patients affected by ulcerative colitis (UC) are more likely to develop colorectal cancer, and are often diagnosed with lymph node involvement (N+) at surgery.

AIM: To identify the risk factors for N+ cancer in UC patients.

METHODS: Patients undergoing surgery from 2001 to 2018 in six European tertiary centres were included. N+ patients were compared to the control group (N-) for clinical variables. The evaluation of risk factors for N+ was assessed using univariate and multivariable logistic regression analyses.

RESULTS: A total of 130 patients were included. Median duration of disease was 21 years (1-52). Forty patients (30.8%) were N+ at surgery. Eighteen (13.8%) developed cancer within 10 years from the onset of UC. Younger age at surgery (Odds ratio -OR- 0.96, p = 0.042), left colon location (OR 2.44, p = 0.045) and the presence of stricture (OR 5.07, p = 0.002) were associated with N+.

CONCLUSION: Location in the left colon, presence of strictures and younger age strongly correlated with a higher risk of N+ cancer, which could develop before the starting point of surveillance. Duration, extension and severity of disease were not associated with N+. These results should be considered in the evaluation of risk of advanced cancer in UC patients.

Original languageEnglish
Pages (from-to)33-37
Number of pages5
JournalDigestive and Liver Disease
Volume52
Issue number1
DOIs
Publication statusPublished - Jan 2020

    Fingerprint

Cite this

Rottoli, M., Tanzanu, M., Di Candido, F., Colombo, F., Frontali, A., Chandrasinghe, P. C., Pellino, G., Frasson, M., Warusavitarne, J., Panis, Y., Sampietro, G. M., Spinelli, A., & Poggioli, G. (2020). Risk factors for locally advanced cancer associated with ulcerative colitis: Results of a retrospective multicentric study in the era of biologics. Digestive and Liver Disease, 52(1), 33-37. https://doi.org/10.1016/j.dld.2019.08.024