Risk factors for locally advanced cancer associated with ulcerative colitis: Results of a retrospective multicentric study in the era of biologics

Matteo Rottoli; Marta Tanzanu; Francesca Di Candido; Francesco Colombo; Alice Frontali; Pramodh C Chandrasinghe; Gianluca Pellino; Matteo Frasson; Janindra Warusavitarne; Yves Panis; Gianluca M Sampietro; Antonino Spinelli; Gilberto Poggioli

doi:10.1016/j.dld.2019.08.024

Risk factors for locally advanced cancer associated with ulcerative colitis: Results of a retrospective multicentric study in the era of biologics

Matteo Rottoli, Marta Tanzanu, Francesca Di Candido, Francesco Colombo, Alice Frontali, Pramodh C Chandrasinghe, Gianluca Pellino, Matteo Frasson, Janindra Warusavitarne, Yves Panis, Gianluca M Sampietro, Antonino Spinelli, Gilberto Poggioli

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Patients affected by ulcerative colitis (UC) are more likely to develop colorectal cancer, and are often diagnosed with lymph node involvement (N+) at surgery.

AIM: To identify the risk factors for N+ cancer in UC patients.

METHODS: Patients undergoing surgery from 2001 to 2018 in six European tertiary centres were included. N+ patients were compared to the control group (N-) for clinical variables. The evaluation of risk factors for N+ was assessed using univariate and multivariable logistic regression analyses.

RESULTS: A total of 130 patients were included. Median duration of disease was 21 years (1-52). Forty patients (30.8%) were N+ at surgery. Eighteen (13.8%) developed cancer within 10 years from the onset of UC. Younger age at surgery (Odds ratio -OR- 0.96, p = 0.042), left colon location (OR 2.44, p = 0.045) and the presence of stricture (OR 5.07, p = 0.002) were associated with N+.

CONCLUSION: Location in the left colon, presence of strictures and younger age strongly correlated with a higher risk of N+ cancer, which could develop before the starting point of surveillance. Duration, extension and severity of disease were not associated with N+. These results should be considered in the evaluation of risk of advanced cancer in UC patients.

Original language	English
Pages (from-to)	33-37
Number of pages	5
Journal	Digestive and Liver Disease
Volume	52
Issue number	1
DOIs	https://doi.org/10.1016/j.dld.2019.08.024
Publication status	Published - Jan 2020

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Rottoli, M., Tanzanu, M., Di Candido, F., Colombo, F., Frontali, A., Chandrasinghe, P. C., Pellino, G., Frasson, M., Warusavitarne, J., Panis, Y., Sampietro, G. M., Spinelli, A., & Poggioli, G. (2020). Risk factors for locally advanced cancer associated with ulcerative colitis: Results of a retrospective multicentric study in the era of biologics. Digestive and Liver Disease, 52(1), 33-37. https://doi.org/10.1016/j.dld.2019.08.024

Risk factors for locally advanced cancer associated with ulcerative colitis : Results of a retrospective multicentric study in the era of biologics. / Rottoli, Matteo; Tanzanu, Marta; Di Candido, Francesca; Colombo, Francesco; Frontali, Alice; Chandrasinghe, Pramodh C; Pellino, Gianluca; Frasson, Matteo; Warusavitarne, Janindra; Panis, Yves; Sampietro, Gianluca M; Spinelli, Antonino; Poggioli, Gilberto.

In: Digestive and Liver Disease, Vol. 52, No. 1, 01.2020, p. 33-37.

Research output: Contribution to journal › Article › peer-review

Rottoli, M, Tanzanu, M, Di Candido, F, Colombo, F, Frontali, A, Chandrasinghe, PC, Pellino, G, Frasson, M, Warusavitarne, J, Panis, Y, Sampietro, GM, Spinelli, A & Poggioli, G 2020, 'Risk factors for locally advanced cancer associated with ulcerative colitis: Results of a retrospective multicentric study in the era of biologics', Digestive and Liver Disease, vol. 52, no. 1, pp. 33-37. https://doi.org/10.1016/j.dld.2019.08.024

Rottoli, Matteo ; Tanzanu, Marta ; Di Candido, Francesca ; Colombo, Francesco ; Frontali, Alice ; Chandrasinghe, Pramodh C ; Pellino, Gianluca ; Frasson, Matteo ; Warusavitarne, Janindra ; Panis, Yves ; Sampietro, Gianluca M ; Spinelli, Antonino ; Poggioli, Gilberto. / Risk factors for locally advanced cancer associated with ulcerative colitis : Results of a retrospective multicentric study in the era of biologics. In: Digestive and Liver Disease. 2020 ; Vol. 52, No. 1. pp. 33-37.

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title = "Risk factors for locally advanced cancer associated with ulcerative colitis: Results of a retrospective multicentric study in the era of biologics",

abstract = "BACKGROUND: Patients affected by ulcerative colitis (UC) are more likely to develop colorectal cancer, and are often diagnosed with lymph node involvement (N+) at surgery.AIM: To identify the risk factors for N+ cancer in UC patients.METHODS: Patients undergoing surgery from 2001 to 2018 in six European tertiary centres were included. N+ patients were compared to the control group (N-) for clinical variables. The evaluation of risk factors for N+ was assessed using univariate and multivariable logistic regression analyses.RESULTS: A total of 130 patients were included. Median duration of disease was 21 years (1-52). Forty patients (30.8%) were N+ at surgery. Eighteen (13.8%) developed cancer within 10 years from the onset of UC. Younger age at surgery (Odds ratio -OR- 0.96, p = 0.042), left colon location (OR 2.44, p = 0.045) and the presence of stricture (OR 5.07, p = 0.002) were associated with N+.CONCLUSION: Location in the left colon, presence of strictures and younger age strongly correlated with a higher risk of N+ cancer, which could develop before the starting point of surveillance. Duration, extension and severity of disease were not associated with N+. These results should be considered in the evaluation of risk of advanced cancer in UC patients.",

author = "Matteo Rottoli and Marta Tanzanu and {Di Candido}, Francesca and Francesco Colombo and Alice Frontali and Chandrasinghe, {Pramodh C} and Gianluca Pellino and Matteo Frasson and Janindra Warusavitarne and Yves Panis and Sampietro, {Gianluca M} and Antonino Spinelli and Gilberto Poggioli",

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doi = "10.1016/j.dld.2019.08.024",

language = "English",

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T2 - Results of a retrospective multicentric study in the era of biologics

AU - Rottoli, Matteo

AU - Tanzanu, Marta

AU - Di Candido, Francesca

AU - Colombo, Francesco

AU - Frontali, Alice

AU - Chandrasinghe, Pramodh C

AU - Pellino, Gianluca

AU - Frasson, Matteo

AU - Warusavitarne, Janindra

AU - Panis, Yves

AU - Sampietro, Gianluca M

AU - Spinelli, Antonino

AU - Poggioli, Gilberto

PY - 2020/1

Y1 - 2020/1

N2 - BACKGROUND: Patients affected by ulcerative colitis (UC) are more likely to develop colorectal cancer, and are often diagnosed with lymph node involvement (N+) at surgery.AIM: To identify the risk factors for N+ cancer in UC patients.METHODS: Patients undergoing surgery from 2001 to 2018 in six European tertiary centres were included. N+ patients were compared to the control group (N-) for clinical variables. The evaluation of risk factors for N+ was assessed using univariate and multivariable logistic regression analyses.RESULTS: A total of 130 patients were included. Median duration of disease was 21 years (1-52). Forty patients (30.8%) were N+ at surgery. Eighteen (13.8%) developed cancer within 10 years from the onset of UC. Younger age at surgery (Odds ratio -OR- 0.96, p = 0.042), left colon location (OR 2.44, p = 0.045) and the presence of stricture (OR 5.07, p = 0.002) were associated with N+.CONCLUSION: Location in the left colon, presence of strictures and younger age strongly correlated with a higher risk of N+ cancer, which could develop before the starting point of surveillance. Duration, extension and severity of disease were not associated with N+. These results should be considered in the evaluation of risk of advanced cancer in UC patients.

AB - BACKGROUND: Patients affected by ulcerative colitis (UC) are more likely to develop colorectal cancer, and are often diagnosed with lymph node involvement (N+) at surgery.AIM: To identify the risk factors for N+ cancer in UC patients.METHODS: Patients undergoing surgery from 2001 to 2018 in six European tertiary centres were included. N+ patients were compared to the control group (N-) for clinical variables. The evaluation of risk factors for N+ was assessed using univariate and multivariable logistic regression analyses.RESULTS: A total of 130 patients were included. Median duration of disease was 21 years (1-52). Forty patients (30.8%) were N+ at surgery. Eighteen (13.8%) developed cancer within 10 years from the onset of UC. Younger age at surgery (Odds ratio -OR- 0.96, p = 0.042), left colon location (OR 2.44, p = 0.045) and the presence of stricture (OR 5.07, p = 0.002) were associated with N+.CONCLUSION: Location in the left colon, presence of strictures and younger age strongly correlated with a higher risk of N+ cancer, which could develop before the starting point of surveillance. Duration, extension and severity of disease were not associated with N+. These results should be considered in the evaluation of risk of advanced cancer in UC patients.

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