Risk factors for malignant progression of intraductal papillary mucinous neoplasms

Maria Moris, Massimo Raimondo, Timothy A. Woodward, Verna Skinner, Paolo G. Arcidiacono, Maria C. Petrone, Claudio De Angelis, Selene Manfrè, Pietro Fusaroli, Michael B. Wallace

Research output: Contribution to journalArticle

Abstract

Background: Intraductal papillary mucinous neoplasms of the pancreas are increasingly diagnosed. Due to their malignant potential, greater understanding of their nature is required. Aims: Define risk factors for malignancy in intraductal papillary mucinous neoplasms. Methods: An international, multicentre study was performed in Europe and the United States. Clinical databases were reviewed for patients with intraductal papillary mucinous neoplasms diagnosis. Results: Of 1126 patients, 84 were diagnosed with invasive carcinoma/high-grade dysplasia and were compared to the rest of the cohort. Multivariate logistic analysis showed a statistically significant association between cancer/high-grade dysplasia and the variables smoking history (OR 1.9, 95% CI [1.1-3.1]), body mass index (OR 1.1, 95% CI [1-1.1]), symptoms (OR 3.4, 95% CI [1.9-6]), jaundice (OR 0.1, 95% CI [0-0.3]), and steatorrhea (OR 0.3, 95% CI [0.1-0.8]). Univariate analysis showed no association between malignancy and the cyst number/location (. p=. 0.3 and p=. 0.5, respectively) although a strong association was shown for cyst size (. p

Original languageEnglish
Pages (from-to)495-501
Number of pages7
JournalDigestive and Liver Disease
Volume47
Issue number6
DOIs
Publication statusPublished - Jun 1 2015

Keywords

  • Pancreatic adenocarcinoma
  • Pancreatic cystic neoplasm

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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    Moris, M., Raimondo, M., Woodward, T. A., Skinner, V., Arcidiacono, P. G., Petrone, M. C., De Angelis, C., Manfrè, S., Fusaroli, P., & Wallace, M. B. (2015). Risk factors for malignant progression of intraductal papillary mucinous neoplasms. Digestive and Liver Disease, 47(6), 495-501. https://doi.org/10.1016/j.dld.2015.03.007