Risk factors for medullary thyroid carcinoma: A pooled analysis

Eva Negri, Elaine Ron, Silvia Franceschi, Carlo La Vecchia, Susan Preston-Martin, Laurence Kolonel, Ruth A. Kleinerman, Kiyohiko Mabuchi, Fan Jin, Gun Wingren, Arne Hallquist, Fabio Levi, Athena Linos, Joseph F. Fraumeni

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Objective: To investigate risk factors for medullary thyroid cancer (MTC). Methods: We conducted a pooled analysis of 14 case-control studies from Europe, North America, and Asia, including 67 medullary cancers (43 women and 24 men) diagnosed in ten studies. Of the original 4776, we selected five controls per case matched on study, gender, and age. The pooled odds ratios (OR) were estimated using conditional logistic regression. Results: Education, weight, and body mass were not associated with MTC, but a significant positive relationship was seen with height (OR = 2.6 for highest vs lowest tertile). Significant excess risks were associated with a history of thyroid nodules (OR = 12), hypertension (OR = 2.3), gallbladder disease (OR = 4.3), and allergies (OR = 2.2). Among current smokers, a decreased risk of MTC was observed with increasing number of cigarettes. The risk was significantly elevated among women having a first birth after age 25 years, but no clear pattern emerged for other reproductive factors. Conclusions: Although the number of MTC was small, we detected several significant associations, including prior thyroid and other diseases.

Original languageEnglish
Pages (from-to)365-372
Number of pages8
JournalCancer Causes and Control
Volume13
Issue number4
DOIs
Publication statusPublished - 2002

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Odds Ratio
Northern Asia
Gallbladder Diseases
Thyroid Nodule
Birth Order
Thyroid Diseases
North America
Tobacco Products
Medullary Thyroid cancer
Case-Control Studies
Hypersensitivity
Logistic Models
Body Weight
Hypertension
Education
Neoplasms

Keywords

  • Case-control studies
  • Epidemiology
  • Medullary thyroid carcinoma
  • Risk

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

Cite this

Negri, E., Ron, E., Franceschi, S., La Vecchia, C., Preston-Martin, S., Kolonel, L., ... Fraumeni, J. F. (2002). Risk factors for medullary thyroid carcinoma: A pooled analysis. Cancer Causes and Control, 13(4), 365-372. https://doi.org/10.1023/A:1015263718760

Risk factors for medullary thyroid carcinoma : A pooled analysis. / Negri, Eva; Ron, Elaine; Franceschi, Silvia; La Vecchia, Carlo; Preston-Martin, Susan; Kolonel, Laurence; Kleinerman, Ruth A.; Mabuchi, Kiyohiko; Jin, Fan; Wingren, Gun; Hallquist, Arne; Levi, Fabio; Linos, Athena; Fraumeni, Joseph F.

In: Cancer Causes and Control, Vol. 13, No. 4, 2002, p. 365-372.

Research output: Contribution to journalArticle

Negri, E, Ron, E, Franceschi, S, La Vecchia, C, Preston-Martin, S, Kolonel, L, Kleinerman, RA, Mabuchi, K, Jin, F, Wingren, G, Hallquist, A, Levi, F, Linos, A & Fraumeni, JF 2002, 'Risk factors for medullary thyroid carcinoma: A pooled analysis', Cancer Causes and Control, vol. 13, no. 4, pp. 365-372. https://doi.org/10.1023/A:1015263718760
Negri E, Ron E, Franceschi S, La Vecchia C, Preston-Martin S, Kolonel L et al. Risk factors for medullary thyroid carcinoma: A pooled analysis. Cancer Causes and Control. 2002;13(4):365-372. https://doi.org/10.1023/A:1015263718760
Negri, Eva ; Ron, Elaine ; Franceschi, Silvia ; La Vecchia, Carlo ; Preston-Martin, Susan ; Kolonel, Laurence ; Kleinerman, Ruth A. ; Mabuchi, Kiyohiko ; Jin, Fan ; Wingren, Gun ; Hallquist, Arne ; Levi, Fabio ; Linos, Athena ; Fraumeni, Joseph F. / Risk factors for medullary thyroid carcinoma : A pooled analysis. In: Cancer Causes and Control. 2002 ; Vol. 13, No. 4. pp. 365-372.
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