Abstract
Objective: To investigate risk factors for medullary thyroid cancer (MTC). Methods: We conducted a pooled analysis of 14 case-control studies from Europe, North America, and Asia, including 67 medullary cancers (43 women and 24 men) diagnosed in ten studies. Of the original 4776, we selected five controls per case matched on study, gender, and age. The pooled odds ratios (OR) were estimated using conditional logistic regression. Results: Education, weight, and body mass were not associated with MTC, but a significant positive relationship was seen with height (OR = 2.6 for highest vs lowest tertile). Significant excess risks were associated with a history of thyroid nodules (OR = 12), hypertension (OR = 2.3), gallbladder disease (OR = 4.3), and allergies (OR = 2.2). Among current smokers, a decreased risk of MTC was observed with increasing number of cigarettes. The risk was significantly elevated among women having a first birth after age 25 years, but no clear pattern emerged for other reproductive factors. Conclusions: Although the number of MTC was small, we detected several significant associations, including prior thyroid and other diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 365-372 |
| Number of pages | 8 |
| Journal | Cancer Causes and Control |
| Volume | 13 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- Case-control studies
- Epidemiology
- Medullary thyroid carcinoma
- Risk
ASJC Scopus subject areas
- Oncology
- Epidemiology
- Cancer Research
Cite this
Risk factors for medullary thyroid carcinoma : A pooled analysis. / Negri, Eva; Ron, Elaine; Franceschi, Silvia; La Vecchia, Carlo; Preston-Martin, Susan; Kolonel, Laurence; Kleinerman, Ruth A.; Mabuchi, Kiyohiko; Jin, Fan; Wingren, Gun; Hallquist, Arne; Levi, Fabio; Linos, Athena; Fraumeni, Joseph F.
In: Cancer Causes and Control, Vol. 13, No. 4, 2002, p. 365-372.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Risk factors for medullary thyroid carcinoma
T2 - A pooled analysis
AU - Negri, Eva
AU - Ron, Elaine
AU - Franceschi, Silvia
AU - La Vecchia, Carlo
AU - Preston-Martin, Susan
AU - Kolonel, Laurence
AU - Kleinerman, Ruth A.
AU - Mabuchi, Kiyohiko
AU - Jin, Fan
AU - Wingren, Gun
AU - Hallquist, Arne
AU - Levi, Fabio
AU - Linos, Athena
AU - Fraumeni, Joseph F.
PY - 2002
Y1 - 2002
N2 - Objective: To investigate risk factors for medullary thyroid cancer (MTC). Methods: We conducted a pooled analysis of 14 case-control studies from Europe, North America, and Asia, including 67 medullary cancers (43 women and 24 men) diagnosed in ten studies. Of the original 4776, we selected five controls per case matched on study, gender, and age. The pooled odds ratios (OR) were estimated using conditional logistic regression. Results: Education, weight, and body mass were not associated with MTC, but a significant positive relationship was seen with height (OR = 2.6 for highest vs lowest tertile). Significant excess risks were associated with a history of thyroid nodules (OR = 12), hypertension (OR = 2.3), gallbladder disease (OR = 4.3), and allergies (OR = 2.2). Among current smokers, a decreased risk of MTC was observed with increasing number of cigarettes. The risk was significantly elevated among women having a first birth after age 25 years, but no clear pattern emerged for other reproductive factors. Conclusions: Although the number of MTC was small, we detected several significant associations, including prior thyroid and other diseases.
AB - Objective: To investigate risk factors for medullary thyroid cancer (MTC). Methods: We conducted a pooled analysis of 14 case-control studies from Europe, North America, and Asia, including 67 medullary cancers (43 women and 24 men) diagnosed in ten studies. Of the original 4776, we selected five controls per case matched on study, gender, and age. The pooled odds ratios (OR) were estimated using conditional logistic regression. Results: Education, weight, and body mass were not associated with MTC, but a significant positive relationship was seen with height (OR = 2.6 for highest vs lowest tertile). Significant excess risks were associated with a history of thyroid nodules (OR = 12), hypertension (OR = 2.3), gallbladder disease (OR = 4.3), and allergies (OR = 2.2). Among current smokers, a decreased risk of MTC was observed with increasing number of cigarettes. The risk was significantly elevated among women having a first birth after age 25 years, but no clear pattern emerged for other reproductive factors. Conclusions: Although the number of MTC was small, we detected several significant associations, including prior thyroid and other diseases.
KW - Case-control studies
KW - Epidemiology
KW - Medullary thyroid carcinoma
KW - Risk
UR - http://www.scopus.com/inward/record.url?scp=0036001342&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036001342&partnerID=8YFLogxK
U2 - 10.1023/A:1015263718760
DO - 10.1023/A:1015263718760
M3 - Article
C2 - 12074506
AN - SCOPUS:0036001342
VL - 13
SP - 365
EP - 372
JO - Cancer Causes and Control
JF - Cancer Causes and Control
SN - 0957-5243
IS - 4
ER -