Risk factors for ovarian cancer histotypes

Francesca Chiaffarino, Fabio Parazzini, Cristina Bosetti, Silvia Franceschi, Renato Talamini, Vincenzo Canzonieri, Maurizio Montella, Valerio Ramazzotti, Silvia Franceschi, Carlo La Vecchia

Research output: Contribution to journalArticlepeer-review

Abstract

To analyse the risk factors for different histologic types of ovarian cancer, we conducted a case-control study. The cases included 750 women with incident, histologically confirmed invasive epithelial ovarian cancer subdivided into: 493 serous, 81 mucinous, 78 endometrioid, and 98 other histologies. The controls included 2411 women admitted to the same hospitals as cases. The odds ratios for women with three or more births, in comparison with nulliparae, were 0.6 for serous, 0.4 for endometrioid, 1.0 for mucinous and 0.7 for other histological types of ovarian cancer. Family history of ovarian/breast cancer was associated to the risk of all ovarian cancer types, except mucinous ones. Selected dietary factors were less strongly directly (meat and starch), or inversely (fish and vitamin E) related to mucinous than to other histological types of ovarian cancer. High occupational physical activity was inversely related to the risk of ovarian cancer, with no heterogeneity across histologies. In conclusion, the association of reproductive factors and of selected dietary habits was weaker for mucinous ovarian cancer than for other histologic types.

Original languageEnglish
Pages (from-to)1208-1213
Number of pages6
JournalEuropean Journal of Cancer
Volume43
Issue number7
DOIs
Publication statusPublished - May 2007

Keywords

  • Epidemiology
  • Family history
  • Histological types
  • Hormones
  • Ovarian cancer
  • Physical activity
  • Reproductive factors

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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