TY - JOUR
T1 - Risk factors for ovarian cancer histotypes
AU - Chiaffarino, Francesca
AU - Parazzini, Fabio
AU - Bosetti, Cristina
AU - Franceschi, Silvia
AU - Talamini, Renato
AU - Canzonieri, Vincenzo
AU - Montella, Maurizio
AU - Ramazzotti, Valerio
AU - Franceschi, Silvia
AU - La Vecchia, Carlo
PY - 2007/5
Y1 - 2007/5
N2 - To analyse the risk factors for different histologic types of ovarian cancer, we conducted a case-control study. The cases included 750 women with incident, histologically confirmed invasive epithelial ovarian cancer subdivided into: 493 serous, 81 mucinous, 78 endometrioid, and 98 other histologies. The controls included 2411 women admitted to the same hospitals as cases. The odds ratios for women with three or more births, in comparison with nulliparae, were 0.6 for serous, 0.4 for endometrioid, 1.0 for mucinous and 0.7 for other histological types of ovarian cancer. Family history of ovarian/breast cancer was associated to the risk of all ovarian cancer types, except mucinous ones. Selected dietary factors were less strongly directly (meat and starch), or inversely (fish and vitamin E) related to mucinous than to other histological types of ovarian cancer. High occupational physical activity was inversely related to the risk of ovarian cancer, with no heterogeneity across histologies. In conclusion, the association of reproductive factors and of selected dietary habits was weaker for mucinous ovarian cancer than for other histologic types.
AB - To analyse the risk factors for different histologic types of ovarian cancer, we conducted a case-control study. The cases included 750 women with incident, histologically confirmed invasive epithelial ovarian cancer subdivided into: 493 serous, 81 mucinous, 78 endometrioid, and 98 other histologies. The controls included 2411 women admitted to the same hospitals as cases. The odds ratios for women with three or more births, in comparison with nulliparae, were 0.6 for serous, 0.4 for endometrioid, 1.0 for mucinous and 0.7 for other histological types of ovarian cancer. Family history of ovarian/breast cancer was associated to the risk of all ovarian cancer types, except mucinous ones. Selected dietary factors were less strongly directly (meat and starch), or inversely (fish and vitamin E) related to mucinous than to other histological types of ovarian cancer. High occupational physical activity was inversely related to the risk of ovarian cancer, with no heterogeneity across histologies. In conclusion, the association of reproductive factors and of selected dietary habits was weaker for mucinous ovarian cancer than for other histologic types.
KW - Epidemiology
KW - Family history
KW - Histological types
KW - Hormones
KW - Ovarian cancer
KW - Physical activity
KW - Reproductive factors
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U2 - 10.1016/j.ejca.2007.01.035
DO - 10.1016/j.ejca.2007.01.035
M3 - Article
C2 - 17376671
AN - SCOPUS:34247164420
VL - 43
SP - 1208
EP - 1213
JO - European Journal of Cancer
JF - European Journal of Cancer
SN - 0959-8049
IS - 7
ER -