Abstract
Background: As few data are available on irradiation of the draining nodes after conservative surgery (CS), this study was designed to identify patients with T1-T2 breast cancer and one to three positive axillary nodes who needed regional radiotherapy (RT). Patients and methods: Five hundred seventy-five patients were treated between 1988 and 2001 with CS and RT to the breast. All but three received adjuvant chemotherapy and/or hormone therapy. Risk factors for and the relationships between local, nodal and distant relapses were analyzed. Results: At a median follow-up of 7.3 years, the 10-year probability of survival free of local relapse, nodal relapse and distant metastases were 92.8%, 94.0% and 84.9%, respectively. Independent predictors of local relapse were the positive/excised node ratio, margin status and age. Predictors of nodal relapse were tumor grade, hormone receptor and margin status. Significant risk factors for distant metastases were tumor stage, grade, hormone receptor and margin status. Local and nodal relapses were related significantly with distant metastases. Only local and distant relapses were linked by temporal sequence (P = 0.03). Conclusions: Overall relapse rates were low in these patients and different mechanisms appeared to underlie local, nodal or distant relapse.
| Original language | English |
|---|---|
| Pages (from-to) | 842-847 |
| Number of pages | 6 |
| Journal | Annals of Oncology |
| Volume | 22 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2011 |
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Keywords
- Conservative treatment
- Distant metastases
- Early breast cancer
- Local and nodal relapses
- Prognostic factors
ASJC Scopus subject areas
- Oncology
- Hematology
Cite this
Risk factors for relapse after conservative treatment in T1-T2 breast cancer with one to three positive axillary nodes : Results of an observational study. / Aristei, C.; Leonardi, C.; Stracci, F.; Palumbo, I.; Luini, A.; Viale, G.; Cristallini, E. G.; Cavaliere, A.; Orecchia, R.
In: Annals of Oncology, Vol. 22, No. 4, 2011, p. 842-847.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Risk factors for relapse after conservative treatment in T1-T2 breast cancer with one to three positive axillary nodes
T2 - Results of an observational study
AU - Aristei, C.
AU - Leonardi, C.
AU - Stracci, F.
AU - Palumbo, I.
AU - Luini, A.
AU - Viale, G.
AU - Cristallini, E. G.
AU - Cavaliere, A.
AU - Orecchia, R.
PY - 2011
Y1 - 2011
N2 - Background: As few data are available on irradiation of the draining nodes after conservative surgery (CS), this study was designed to identify patients with T1-T2 breast cancer and one to three positive axillary nodes who needed regional radiotherapy (RT). Patients and methods: Five hundred seventy-five patients were treated between 1988 and 2001 with CS and RT to the breast. All but three received adjuvant chemotherapy and/or hormone therapy. Risk factors for and the relationships between local, nodal and distant relapses were analyzed. Results: At a median follow-up of 7.3 years, the 10-year probability of survival free of local relapse, nodal relapse and distant metastases were 92.8%, 94.0% and 84.9%, respectively. Independent predictors of local relapse were the positive/excised node ratio, margin status and age. Predictors of nodal relapse were tumor grade, hormone receptor and margin status. Significant risk factors for distant metastases were tumor stage, grade, hormone receptor and margin status. Local and nodal relapses were related significantly with distant metastases. Only local and distant relapses were linked by temporal sequence (P = 0.03). Conclusions: Overall relapse rates were low in these patients and different mechanisms appeared to underlie local, nodal or distant relapse.
AB - Background: As few data are available on irradiation of the draining nodes after conservative surgery (CS), this study was designed to identify patients with T1-T2 breast cancer and one to three positive axillary nodes who needed regional radiotherapy (RT). Patients and methods: Five hundred seventy-five patients were treated between 1988 and 2001 with CS and RT to the breast. All but three received adjuvant chemotherapy and/or hormone therapy. Risk factors for and the relationships between local, nodal and distant relapses were analyzed. Results: At a median follow-up of 7.3 years, the 10-year probability of survival free of local relapse, nodal relapse and distant metastases were 92.8%, 94.0% and 84.9%, respectively. Independent predictors of local relapse were the positive/excised node ratio, margin status and age. Predictors of nodal relapse were tumor grade, hormone receptor and margin status. Significant risk factors for distant metastases were tumor stage, grade, hormone receptor and margin status. Local and nodal relapses were related significantly with distant metastases. Only local and distant relapses were linked by temporal sequence (P = 0.03). Conclusions: Overall relapse rates were low in these patients and different mechanisms appeared to underlie local, nodal or distant relapse.
KW - Conservative treatment
KW - Distant metastases
KW - Early breast cancer
KW - Local and nodal relapses
KW - Prognostic factors
UR - http://www.scopus.com/inward/record.url?scp=79953307884&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79953307884&partnerID=8YFLogxK
U2 - 10.1093/annonc/mdq470
DO - 10.1093/annonc/mdq470
M3 - Article
C2 - 21048040
AN - SCOPUS:79953307884
VL - 22
SP - 842
EP - 847
JO - Annals of Oncology
JF - Annals of Oncology
SN - 0923-7534
IS - 4
ER -