Risk factors for relapse after conservative treatment in T1-T2 breast cancer with one to three positive axillary nodes

Results of an observational study

C. Aristei, C. Leonardi, F. Stracci, I. Palumbo, A. Luini, G. Viale, E. G. Cristallini, A. Cavaliere, R. Orecchia

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: As few data are available on irradiation of the draining nodes after conservative surgery (CS), this study was designed to identify patients with T1-T2 breast cancer and one to three positive axillary nodes who needed regional radiotherapy (RT). Patients and methods: Five hundred seventy-five patients were treated between 1988 and 2001 with CS and RT to the breast. All but three received adjuvant chemotherapy and/or hormone therapy. Risk factors for and the relationships between local, nodal and distant relapses were analyzed. Results: At a median follow-up of 7.3 years, the 10-year probability of survival free of local relapse, nodal relapse and distant metastases were 92.8%, 94.0% and 84.9%, respectively. Independent predictors of local relapse were the positive/excised node ratio, margin status and age. Predictors of nodal relapse were tumor grade, hormone receptor and margin status. Significant risk factors for distant metastases were tumor stage, grade, hormone receptor and margin status. Local and nodal relapses were related significantly with distant metastases. Only local and distant relapses were linked by temporal sequence (P = 0.03). Conclusions: Overall relapse rates were low in these patients and different mechanisms appeared to underlie local, nodal or distant relapse.

Original languageEnglish
Pages (from-to)842-847
Number of pages6
JournalAnnals of Oncology
Volume22
Issue number4
DOIs
Publication statusPublished - 2011

Fingerprint

Observational Studies
Breast Neoplasms
Recurrence
Hormones
Neoplasm Metastasis
Radiotherapy
Conservative Treatment
Adjuvant Chemotherapy
Neoplasms
Breast
Survival

Keywords

  • Conservative treatment
  • Distant metastases
  • Early breast cancer
  • Local and nodal relapses
  • Prognostic factors

ASJC Scopus subject areas

  • Oncology
  • Hematology

Cite this

Risk factors for relapse after conservative treatment in T1-T2 breast cancer with one to three positive axillary nodes : Results of an observational study. / Aristei, C.; Leonardi, C.; Stracci, F.; Palumbo, I.; Luini, A.; Viale, G.; Cristallini, E. G.; Cavaliere, A.; Orecchia, R.

In: Annals of Oncology, Vol. 22, No. 4, 2011, p. 842-847.

Research output: Contribution to journalArticle

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abstract = "Background: As few data are available on irradiation of the draining nodes after conservative surgery (CS), this study was designed to identify patients with T1-T2 breast cancer and one to three positive axillary nodes who needed regional radiotherapy (RT). Patients and methods: Five hundred seventy-five patients were treated between 1988 and 2001 with CS and RT to the breast. All but three received adjuvant chemotherapy and/or hormone therapy. Risk factors for and the relationships between local, nodal and distant relapses were analyzed. Results: At a median follow-up of 7.3 years, the 10-year probability of survival free of local relapse, nodal relapse and distant metastases were 92.8{\%}, 94.0{\%} and 84.9{\%}, respectively. Independent predictors of local relapse were the positive/excised node ratio, margin status and age. Predictors of nodal relapse were tumor grade, hormone receptor and margin status. Significant risk factors for distant metastases were tumor stage, grade, hormone receptor and margin status. Local and nodal relapses were related significantly with distant metastases. Only local and distant relapses were linked by temporal sequence (P = 0.03). Conclusions: Overall relapse rates were low in these patients and different mechanisms appeared to underlie local, nodal or distant relapse.",
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T1 - Risk factors for relapse after conservative treatment in T1-T2 breast cancer with one to three positive axillary nodes

T2 - Results of an observational study

AU - Aristei, C.

AU - Leonardi, C.

AU - Stracci, F.

AU - Palumbo, I.

AU - Luini, A.

AU - Viale, G.

AU - Cristallini, E. G.

AU - Cavaliere, A.

AU - Orecchia, R.

PY - 2011

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AB - Background: As few data are available on irradiation of the draining nodes after conservative surgery (CS), this study was designed to identify patients with T1-T2 breast cancer and one to three positive axillary nodes who needed regional radiotherapy (RT). Patients and methods: Five hundred seventy-five patients were treated between 1988 and 2001 with CS and RT to the breast. All but three received adjuvant chemotherapy and/or hormone therapy. Risk factors for and the relationships between local, nodal and distant relapses were analyzed. Results: At a median follow-up of 7.3 years, the 10-year probability of survival free of local relapse, nodal relapse and distant metastases were 92.8%, 94.0% and 84.9%, respectively. Independent predictors of local relapse were the positive/excised node ratio, margin status and age. Predictors of nodal relapse were tumor grade, hormone receptor and margin status. Significant risk factors for distant metastases were tumor stage, grade, hormone receptor and margin status. Local and nodal relapses were related significantly with distant metastases. Only local and distant relapses were linked by temporal sequence (P = 0.03). Conclusions: Overall relapse rates were low in these patients and different mechanisms appeared to underlie local, nodal or distant relapse.

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KW - Prognostic factors

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