Risk factors for subtrochanteric and diaphyseal fractures: The study of osteoporotic fractures

Nicola Napoli, Ann V. Schwartz, Lisa Palermo, Jenny J. Jin, Rosanna Wustrack, Jane A. Cauley, Kristine E. Ensrud, Michael Kelly, Dennis M. Black

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Context: Patients on long-term bisphosphonate therapy may have an increased incidence of lowenergy subtrochanteric and diaphyseal (SD) femoral fractures. However, the incidence and risk factors associated with these fractures have not been well defined. Objective: The objective of the study was to determine the incidence of and risk factors for lowenergy SD fractures in the Study of Osteoporotic Fractures (SOF). Design: Low-energy SD fractures were identified from a review of radiographic reports obtained between 1986 and 2010 in women in the SOF. Among the SD fractures, pathological, periprosthetic, and traumatic fractures were excluded. We assessed risk factors for SD fractures as well as risk factors for femoral neck (FN) and intertrochanteric (IT) hip fractures using both age-adjusted and multivariate time-dependent proportional hazards models. During this follow-up, only a small minority had ever used bisphosphonates. Results: Forty-five women sustained low-energy subtrochanteric/diaphyseal femoral fractures over a total follow-up of 140 000 person-years. The incidence of SD fracture was 3.2 per 10 000 person-years compared with a total hip fracture incidence of 110 per 10 000 person-years. A total of about 12% of women reported bisphosphonate use at 1 or more visits. In multivariate analyses, age, total hip bone mineral density (BMD), bisphosphonate use, and history of diabetes emerged as independent risk factors for SD fractures. Risk factors for FN and IT fractures included age, BMD, and history of falls or prior fractures. Bisphosphonate use was protective against FN fractures, whereas there was an increased risk of SD fractures (hazard ratio 2.58, P = .049) with bisphosphonate use after adjustment for other risk factors for fracture. Conclusions: In SOF, low-energy SD fractures were rare occurrences, far outnumbered by FN and IT fractures. Typical risk factors were associated with FN and IT fractures, whereas only age, total hip BMD, and history of diabetes were independent risk factors for SD fractures. In addition, bisphosphonate use was a marginally significantly predictor although the SOF study has limited ability to assess this association.

Original languageEnglish
Pages (from-to)659-667
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume98
Issue number2
DOIs
Publication statusPublished - Feb 2013

Fingerprint

Osteoporotic Fractures
Hip Fractures
Diphosphonates
Femoral Neck Fractures
Pelvic Bones
Bone Density
Incidence
Femoral Fractures
Minerals
Bone
Periprosthetic Fractures
Medical problems
Femur Neck
Hazards
Proportional Hazards Models

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Napoli, N., Schwartz, A. V., Palermo, L., Jin, J. J., Wustrack, R., Cauley, J. A., ... Black, D. M. (2013). Risk factors for subtrochanteric and diaphyseal fractures: The study of osteoporotic fractures. Journal of Clinical Endocrinology and Metabolism, 98(2), 659-667. https://doi.org/10.1210/jc.2012-1896

Risk factors for subtrochanteric and diaphyseal fractures : The study of osteoporotic fractures. / Napoli, Nicola; Schwartz, Ann V.; Palermo, Lisa; Jin, Jenny J.; Wustrack, Rosanna; Cauley, Jane A.; Ensrud, Kristine E.; Kelly, Michael; Black, Dennis M.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 98, No. 2, 02.2013, p. 659-667.

Research output: Contribution to journalArticle

Napoli, N, Schwartz, AV, Palermo, L, Jin, JJ, Wustrack, R, Cauley, JA, Ensrud, KE, Kelly, M & Black, DM 2013, 'Risk factors for subtrochanteric and diaphyseal fractures: The study of osteoporotic fractures', Journal of Clinical Endocrinology and Metabolism, vol. 98, no. 2, pp. 659-667. https://doi.org/10.1210/jc.2012-1896
Napoli, Nicola ; Schwartz, Ann V. ; Palermo, Lisa ; Jin, Jenny J. ; Wustrack, Rosanna ; Cauley, Jane A. ; Ensrud, Kristine E. ; Kelly, Michael ; Black, Dennis M. / Risk factors for subtrochanteric and diaphyseal fractures : The study of osteoporotic fractures. In: Journal of Clinical Endocrinology and Metabolism. 2013 ; Vol. 98, No. 2. pp. 659-667.
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T1 - Risk factors for subtrochanteric and diaphyseal fractures

T2 - The study of osteoporotic fractures

AU - Napoli, Nicola

AU - Schwartz, Ann V.

AU - Palermo, Lisa

AU - Jin, Jenny J.

AU - Wustrack, Rosanna

AU - Cauley, Jane A.

AU - Ensrud, Kristine E.

AU - Kelly, Michael

AU - Black, Dennis M.

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N2 - Context: Patients on long-term bisphosphonate therapy may have an increased incidence of lowenergy subtrochanteric and diaphyseal (SD) femoral fractures. However, the incidence and risk factors associated with these fractures have not been well defined. Objective: The objective of the study was to determine the incidence of and risk factors for lowenergy SD fractures in the Study of Osteoporotic Fractures (SOF). Design: Low-energy SD fractures were identified from a review of radiographic reports obtained between 1986 and 2010 in women in the SOF. Among the SD fractures, pathological, periprosthetic, and traumatic fractures were excluded. We assessed risk factors for SD fractures as well as risk factors for femoral neck (FN) and intertrochanteric (IT) hip fractures using both age-adjusted and multivariate time-dependent proportional hazards models. During this follow-up, only a small minority had ever used bisphosphonates. Results: Forty-five women sustained low-energy subtrochanteric/diaphyseal femoral fractures over a total follow-up of 140 000 person-years. The incidence of SD fracture was 3.2 per 10 000 person-years compared with a total hip fracture incidence of 110 per 10 000 person-years. A total of about 12% of women reported bisphosphonate use at 1 or more visits. In multivariate analyses, age, total hip bone mineral density (BMD), bisphosphonate use, and history of diabetes emerged as independent risk factors for SD fractures. Risk factors for FN and IT fractures included age, BMD, and history of falls or prior fractures. Bisphosphonate use was protective against FN fractures, whereas there was an increased risk of SD fractures (hazard ratio 2.58, P = .049) with bisphosphonate use after adjustment for other risk factors for fracture. Conclusions: In SOF, low-energy SD fractures were rare occurrences, far outnumbered by FN and IT fractures. Typical risk factors were associated with FN and IT fractures, whereas only age, total hip BMD, and history of diabetes were independent risk factors for SD fractures. In addition, bisphosphonate use was a marginally significantly predictor although the SOF study has limited ability to assess this association.

AB - Context: Patients on long-term bisphosphonate therapy may have an increased incidence of lowenergy subtrochanteric and diaphyseal (SD) femoral fractures. However, the incidence and risk factors associated with these fractures have not been well defined. Objective: The objective of the study was to determine the incidence of and risk factors for lowenergy SD fractures in the Study of Osteoporotic Fractures (SOF). Design: Low-energy SD fractures were identified from a review of radiographic reports obtained between 1986 and 2010 in women in the SOF. Among the SD fractures, pathological, periprosthetic, and traumatic fractures were excluded. We assessed risk factors for SD fractures as well as risk factors for femoral neck (FN) and intertrochanteric (IT) hip fractures using both age-adjusted and multivariate time-dependent proportional hazards models. During this follow-up, only a small minority had ever used bisphosphonates. Results: Forty-five women sustained low-energy subtrochanteric/diaphyseal femoral fractures over a total follow-up of 140 000 person-years. The incidence of SD fracture was 3.2 per 10 000 person-years compared with a total hip fracture incidence of 110 per 10 000 person-years. A total of about 12% of women reported bisphosphonate use at 1 or more visits. In multivariate analyses, age, total hip bone mineral density (BMD), bisphosphonate use, and history of diabetes emerged as independent risk factors for SD fractures. Risk factors for FN and IT fractures included age, BMD, and history of falls or prior fractures. Bisphosphonate use was protective against FN fractures, whereas there was an increased risk of SD fractures (hazard ratio 2.58, P = .049) with bisphosphonate use after adjustment for other risk factors for fracture. Conclusions: In SOF, low-energy SD fractures were rare occurrences, far outnumbered by FN and IT fractures. Typical risk factors were associated with FN and IT fractures, whereas only age, total hip BMD, and history of diabetes were independent risk factors for SD fractures. In addition, bisphosphonate use was a marginally significantly predictor although the SOF study has limited ability to assess this association.

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