Abstract
Background and Objectives. We evaluated bacterial infections (Bis) in patients with multiple myeloma (MM) treated with two different schedules of vincristine-adriamycin-dexamethasone (VAD). Design and Methods. Ninety-seven patients were studied during 340 VAD cycles. VAD was given by either continuous intravenous infusion (CII) to hospitalized patients or rapid intravenous infusion (RII) to outpatients. The characteristics of patients and VAD schedules were retrospectively analyzed to detect correlations with the incidence of BI. Results. By analyzing each VAD cycle, we found that profound hypogammaglobulinemia (p=0.06) and posttreatment neutropenia (p=0.08) were associated with a trend for a higher risk of infection, while renal function impairment was significantly correlated with BI risk at both univariate (p
Original language | English |
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Pages (from-to) | 1022-1028 |
Number of pages | 7 |
Journal | Haematologica |
Volume | 88 |
Issue number | 9 |
Publication status | Published - Sep 1 2003 |
Keywords
- Bacterial infection
- Multiple myeloma
- VAD
ASJC Scopus subject areas
- Hematology