Risk factors for the development of bacterial infections in patients with multiple myeloma treated with two different vincristine-adriamycin-dexamethasone schedules

Clara Cesana; Anna Maria Nosari; Catherine Klersy; Sara Miqueleiz; Valentina Rossi; Paola Ferrando; Marina Valentini; Luciana Barbarano; Enrica Morra

Risk factors for the development of bacterial infections in patients with multiple myeloma treated with two different vincristine-adriamycin-dexamethasone schedules

Clara Cesana, Anna Maria Nosari, Catherine Klersy, Sara Miqueleiz, Valentina Rossi, Paola Ferrando, Marina Valentini, Luciana Barbarano, Enrica Morra

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Background and Objectives. We evaluated bacterial infections (Bis) in patients with multiple myeloma (MM) treated with two different schedules of vincristine-adriamycin-dexamethasone (VAD). Design and Methods. Ninety-seven patients were studied during 340 VAD cycles. VAD was given by either continuous intravenous infusion (CII) to hospitalized patients or rapid intravenous infusion (RII) to outpatients. The characteristics of patients and VAD schedules were retrospectively analyzed to detect correlations with the incidence of BI. Results. By analyzing each VAD cycle, we found that profound hypogammaglobulinemia (p=0.06) and posttreatment neutropenia (p=0.08) were associated with a trend for a higher risk of infection, while renal function impairment was significantly correlated with BI risk at both univariate (p

Original language	English
Pages (from-to)	1022-1028
Number of pages	7
Journal	Haematologica
Volume	88
Issue number	9
Publication status	Published - Sep 1 2003

Keywords

Bacterial infection
Multiple myeloma
VAD

ASJC Scopus subject areas

Hematology

Cite this

Risk factors for the development of bacterial infections in patients with multiple myeloma treated with two different vincristine-adriamycin-dexamethasone schedules. / Cesana, Clara; Nosari, Anna Maria; Klersy, Catherine; Miqueleiz, Sara; Rossi, Valentina; Ferrando, Paola; Valentini, Marina; Barbarano, Luciana; Morra, Enrica.

In: Haematologica, Vol. 88, No. 9, 01.09.2003, p. 1022-1028.

Research output: Contribution to journal › Article › peer-review

Cesana, Clara ; Nosari, Anna Maria ; Klersy, Catherine ; Miqueleiz, Sara ; Rossi, Valentina ; Ferrando, Paola ; Valentini, Marina ; Barbarano, Luciana ; Morra, Enrica. / Risk factors for the development of bacterial infections in patients with multiple myeloma treated with two different vincristine-adriamycin-dexamethasone schedules. In: Haematologica. 2003 ; Vol. 88, No. 9. pp. 1022-1028.

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abstract = "Background and Objectives. We evaluated bacterial infections (Bis) in patients with multiple myeloma (MM) treated with two different schedules of vincristine-adriamycin-dexamethasone (VAD). Design and Methods. Ninety-seven patients were studied during 340 VAD cycles. VAD was given by either continuous intravenous infusion (CII) to hospitalized patients or rapid intravenous infusion (RII) to outpatients. The characteristics of patients and VAD schedules were retrospectively analyzed to detect correlations with the incidence of BI. Results. By analyzing each VAD cycle, we found that profound hypogammaglobulinemia (p=0.06) and posttreatment neutropenia (p=0.08) were associated with a trend for a higher risk of infection, while renal function impairment was significantly correlated with BI risk at both univariate (p",

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AU - Cesana, Clara

AU - Nosari, Anna Maria

AU - Klersy, Catherine

AU - Miqueleiz, Sara

AU - Rossi, Valentina

AU - Ferrando, Paola

AU - Valentini, Marina

AU - Barbarano, Luciana

AU - Morra, Enrica

PY - 2003/9/1

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N2 - Background and Objectives. We evaluated bacterial infections (Bis) in patients with multiple myeloma (MM) treated with two different schedules of vincristine-adriamycin-dexamethasone (VAD). Design and Methods. Ninety-seven patients were studied during 340 VAD cycles. VAD was given by either continuous intravenous infusion (CII) to hospitalized patients or rapid intravenous infusion (RII) to outpatients. The characteristics of patients and VAD schedules were retrospectively analyzed to detect correlations with the incidence of BI. Results. By analyzing each VAD cycle, we found that profound hypogammaglobulinemia (p=0.06) and posttreatment neutropenia (p=0.08) were associated with a trend for a higher risk of infection, while renal function impairment was significantly correlated with BI risk at both univariate (p

AB - Background and Objectives. We evaluated bacterial infections (Bis) in patients with multiple myeloma (MM) treated with two different schedules of vincristine-adriamycin-dexamethasone (VAD). Design and Methods. Ninety-seven patients were studied during 340 VAD cycles. VAD was given by either continuous intravenous infusion (CII) to hospitalized patients or rapid intravenous infusion (RII) to outpatients. The characteristics of patients and VAD schedules were retrospectively analyzed to detect correlations with the incidence of BI. Results. By analyzing each VAD cycle, we found that profound hypogammaglobulinemia (p=0.06) and posttreatment neutropenia (p=0.08) were associated with a trend for a higher risk of infection, while renal function impairment was significantly correlated with BI risk at both univariate (p

KW - Bacterial infection

KW - Multiple myeloma

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Risk factors for the development of bacterial infections in patients with multiple myeloma treated with two different vincristine-adriamycin-dexamethasone schedules

Abstract

Keywords

ASJC Scopus subject areas

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