Risk factors for unprovoked epileptic seizures in multiple sclerosis:Risk factors for unprovoked epileptic seizures in multiple sclerosis: a systematic review and meta-analysis

Sara Gasparini, Edoardo Ferlazzo, Michele Ascoli, Chiara Sueri, Vittoria Cianci, Concetta Russo, Laura Rosa Pisani, Pasquale Striano, Maurizio Elia, Ettore Beghi, Carmela Colica, Umberto Aguglia, V. Belcastro, A. Bianchi, S. Calabrò, F. De Falco, G. De Maria, C. A. Galimberti, A. Gambardella, A. IudiceA. Labate, A. La Neve, E. Le Piane, F. Monti, L. Mumoli, F. Paladin, F. Pisani, V. Pizza, L. Provinciali, V. Sofia, L. M. Specchio, N. Specchio, S. Striano, F. Villani, G. Zaccara, On behalf of the Epilepsy Study Group of the Italian Neurological Society

Research output: Contribution to journalArticlepeer-review


The role of different factors in influencing the risk of seizures during multiple sclerosis (MS) is not known. To perform a systematic review and meta-analysis of risk factors for epilepsy during MS. Pubmed, Google scholar, and Scopus databases were searched. Articles published in English (1986–2016) were included. Nine studies were included (3 retrospective cohort and 6 case–control) enrolling 2845 MS patients (217 with epilepsy; 7.6%). MS patients with epilepsy had a younger age at onset compared to MS patients without seizures (difference in means = −5.42 years, 95% CI −7.19 to −3.66, p 
Original languageItalian
Pages (from-to)399-406
Number of pages8
JournalNeurological Sciences
Issue number3
Publication statusPublished - Mar 1 2017

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