Risk factors of duodenal ulcer bleeding

The role of smoking and nicotine

F. Di Mario, G. Battaglia, G. Leandro, P. Dotto, N. Dal Bo, S. Salandin, M. Ferrana, S. Grassi, F. Vianello

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Several studies have shown that cigarette smoking affects duodenal ulcer (DU) recurrence. To verify any correlation between smoking and complications of ulcer disease, we studied 33 DU smokers, 16 DU ex-smokers and 87 DU non-smokers for up to 48 months, recording age, sex, family history of ulcer, ulcer symptoms, non-steroidal anti-inflammatory drug use, length of DU history, alcohol consumption, smoking habit, relapses and bleeding episodes. Nicotine contents were also obtained for the type of cigarettes smoked. Statistics used were: Analysis of variance with Bonferroni's test, Pearson's chi-squared test and stepwise logistic regression analysis. Smokers were found to have significantly more relapses but fewer bleeding episodes than ex-smokers and non-smokers (63.3%, 31.2% and 34.5%, p = 0.029; 12.1%, 43.7% and 34.5%, p = 0.017). Bleeders were significantly more often males than non-bleeders (82.9% vs. 61.0%, p = 0.01) and had ulcer symptoms less frequently (9.7% vs. 26.3%, p = 0.02). Multivariate analysis confirmed sex as a risk factor (OR = 3.0) and smoking as a 'protective' factor (OR = 0.4) for bleeding, while nicotine intake was found to be unrelated to this complication. We concluded that smoking (but not nicotine intake) and male sex are factors to take into account in evaluating the risk of DU bleeding.

Original languageEnglish
Pages (from-to)385-391
Number of pages7
JournalItalian Journal of Gastroenterology
Volume26
Issue number8
Publication statusPublished - 1994

Fingerprint

Duodenal Ulcer
Nicotine
Smoking
Hemorrhage
Ulcer
Recurrence
Sex Factors
Tobacco Products
Alcohol Drinking
Habits
Analysis of Variance
Anti-Inflammatory Agents
Multivariate Analysis
Logistic Models
Regression Analysis
Pharmaceutical Preparations

Keywords

  • Duodenal ulcer
  • Nicotine intake
  • Peptic ulcer bleeding
  • Smoking

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Di Mario, F., Battaglia, G., Leandro, G., Dotto, P., Dal Bo, N., Salandin, S., ... Vianello, F. (1994). Risk factors of duodenal ulcer bleeding: The role of smoking and nicotine. Italian Journal of Gastroenterology, 26(8), 385-391.

Risk factors of duodenal ulcer bleeding : The role of smoking and nicotine. / Di Mario, F.; Battaglia, G.; Leandro, G.; Dotto, P.; Dal Bo, N.; Salandin, S.; Ferrana, M.; Grassi, S.; Vianello, F.

In: Italian Journal of Gastroenterology, Vol. 26, No. 8, 1994, p. 385-391.

Research output: Contribution to journalArticle

Di Mario, F, Battaglia, G, Leandro, G, Dotto, P, Dal Bo, N, Salandin, S, Ferrana, M, Grassi, S & Vianello, F 1994, 'Risk factors of duodenal ulcer bleeding: The role of smoking and nicotine', Italian Journal of Gastroenterology, vol. 26, no. 8, pp. 385-391.
Di Mario F, Battaglia G, Leandro G, Dotto P, Dal Bo N, Salandin S et al. Risk factors of duodenal ulcer bleeding: The role of smoking and nicotine. Italian Journal of Gastroenterology. 1994;26(8):385-391.
Di Mario, F. ; Battaglia, G. ; Leandro, G. ; Dotto, P. ; Dal Bo, N. ; Salandin, S. ; Ferrana, M. ; Grassi, S. ; Vianello, F. / Risk factors of duodenal ulcer bleeding : The role of smoking and nicotine. In: Italian Journal of Gastroenterology. 1994 ; Vol. 26, No. 8. pp. 385-391.
@article{14b31498d2fd48d5b52944bc3442603d,
title = "Risk factors of duodenal ulcer bleeding: The role of smoking and nicotine",
abstract = "Several studies have shown that cigarette smoking affects duodenal ulcer (DU) recurrence. To verify any correlation between smoking and complications of ulcer disease, we studied 33 DU smokers, 16 DU ex-smokers and 87 DU non-smokers for up to 48 months, recording age, sex, family history of ulcer, ulcer symptoms, non-steroidal anti-inflammatory drug use, length of DU history, alcohol consumption, smoking habit, relapses and bleeding episodes. Nicotine contents were also obtained for the type of cigarettes smoked. Statistics used were: Analysis of variance with Bonferroni's test, Pearson's chi-squared test and stepwise logistic regression analysis. Smokers were found to have significantly more relapses but fewer bleeding episodes than ex-smokers and non-smokers (63.3{\%}, 31.2{\%} and 34.5{\%}, p = 0.029; 12.1{\%}, 43.7{\%} and 34.5{\%}, p = 0.017). Bleeders were significantly more often males than non-bleeders (82.9{\%} vs. 61.0{\%}, p = 0.01) and had ulcer symptoms less frequently (9.7{\%} vs. 26.3{\%}, p = 0.02). Multivariate analysis confirmed sex as a risk factor (OR = 3.0) and smoking as a 'protective' factor (OR = 0.4) for bleeding, while nicotine intake was found to be unrelated to this complication. We concluded that smoking (but not nicotine intake) and male sex are factors to take into account in evaluating the risk of DU bleeding.",
keywords = "Duodenal ulcer, Nicotine intake, Peptic ulcer bleeding, Smoking",
author = "{Di Mario}, F. and G. Battaglia and G. Leandro and P. Dotto and {Dal Bo}, N. and S. Salandin and M. Ferrana and S. Grassi and F. Vianello",
year = "1994",
language = "English",
volume = "26",
pages = "385--391",
journal = "Italian Journal of Gastroenterology",
issn = "0392-0623",
publisher = "Piccin Editore",
number = "8",

}

TY - JOUR

T1 - Risk factors of duodenal ulcer bleeding

T2 - The role of smoking and nicotine

AU - Di Mario, F.

AU - Battaglia, G.

AU - Leandro, G.

AU - Dotto, P.

AU - Dal Bo, N.

AU - Salandin, S.

AU - Ferrana, M.

AU - Grassi, S.

AU - Vianello, F.

PY - 1994

Y1 - 1994

N2 - Several studies have shown that cigarette smoking affects duodenal ulcer (DU) recurrence. To verify any correlation between smoking and complications of ulcer disease, we studied 33 DU smokers, 16 DU ex-smokers and 87 DU non-smokers for up to 48 months, recording age, sex, family history of ulcer, ulcer symptoms, non-steroidal anti-inflammatory drug use, length of DU history, alcohol consumption, smoking habit, relapses and bleeding episodes. Nicotine contents were also obtained for the type of cigarettes smoked. Statistics used were: Analysis of variance with Bonferroni's test, Pearson's chi-squared test and stepwise logistic regression analysis. Smokers were found to have significantly more relapses but fewer bleeding episodes than ex-smokers and non-smokers (63.3%, 31.2% and 34.5%, p = 0.029; 12.1%, 43.7% and 34.5%, p = 0.017). Bleeders were significantly more often males than non-bleeders (82.9% vs. 61.0%, p = 0.01) and had ulcer symptoms less frequently (9.7% vs. 26.3%, p = 0.02). Multivariate analysis confirmed sex as a risk factor (OR = 3.0) and smoking as a 'protective' factor (OR = 0.4) for bleeding, while nicotine intake was found to be unrelated to this complication. We concluded that smoking (but not nicotine intake) and male sex are factors to take into account in evaluating the risk of DU bleeding.

AB - Several studies have shown that cigarette smoking affects duodenal ulcer (DU) recurrence. To verify any correlation between smoking and complications of ulcer disease, we studied 33 DU smokers, 16 DU ex-smokers and 87 DU non-smokers for up to 48 months, recording age, sex, family history of ulcer, ulcer symptoms, non-steroidal anti-inflammatory drug use, length of DU history, alcohol consumption, smoking habit, relapses and bleeding episodes. Nicotine contents were also obtained for the type of cigarettes smoked. Statistics used were: Analysis of variance with Bonferroni's test, Pearson's chi-squared test and stepwise logistic regression analysis. Smokers were found to have significantly more relapses but fewer bleeding episodes than ex-smokers and non-smokers (63.3%, 31.2% and 34.5%, p = 0.029; 12.1%, 43.7% and 34.5%, p = 0.017). Bleeders were significantly more often males than non-bleeders (82.9% vs. 61.0%, p = 0.01) and had ulcer symptoms less frequently (9.7% vs. 26.3%, p = 0.02). Multivariate analysis confirmed sex as a risk factor (OR = 3.0) and smoking as a 'protective' factor (OR = 0.4) for bleeding, while nicotine intake was found to be unrelated to this complication. We concluded that smoking (but not nicotine intake) and male sex are factors to take into account in evaluating the risk of DU bleeding.

KW - Duodenal ulcer

KW - Nicotine intake

KW - Peptic ulcer bleeding

KW - Smoking

UR - http://www.scopus.com/inward/record.url?scp=0028605702&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028605702&partnerID=8YFLogxK

M3 - Article

VL - 26

SP - 385

EP - 391

JO - Italian Journal of Gastroenterology

JF - Italian Journal of Gastroenterology

SN - 0392-0623

IS - 8

ER -