TY - JOUR
T1 - Risk factors of suspected spondyloarthritis among inflammatory bowel disease patients
AU - Ribaldone, Davide Giuseppe
AU - Vernero, Marta
AU - Parisi, Simone
AU - Ditto, Maria Chiara
AU - Pellicano, Rinaldo
AU - Morino, Mario
AU - Saracco, Giorgio Maria
AU - Fusaro, Enrico
AU - Astegiano, Marco
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: Occurring in approximately 20–30% of patients, spondyloarthritis is the most common extraintestinal manifestation in inflammatory bowel disease (IBD). Aims: To look for risk factors of spondyloarthritis among inflammatory bowel disease patients. Methods: We modified the STRIPP questionnaire created for psoriatic patients and we created a rapid questionnaire for rheumatologic investigation in IBD patients (STRII). We submitted the questionnaire to all consecutive patients with a known spondyloarthritis in our centre and to patients with a negative rheumatological diagnosis to find the cut-off value. Finally, we prospectively submitted the STRII questionnaire to all consecutive IBD patients in our centre. Results: A cut-off ≥3 correlated with spondyloarthritis with an AUC = 0.91. The STRII questionnaire was submitted to 1147 IBD patients. Two hundred and forty-four out of 1147 (21.3%) collected a STRII score of ≥3. Female sex (p <.0001) and Crohn’s disease (p =.023) were risk factors. Patients with a history of at least 1 immunosuppressant or biologic drug (p =.002 and p <.0001, respectively) had a higher rate of positivity to STRII questionnaire. Conclusion: Among IBD patients, females, Crohn’s disease, those with a history of at least 1 immunosuppressive or biological therapy are at increased risk of spondyloarthritis.
AB - Background: Occurring in approximately 20–30% of patients, spondyloarthritis is the most common extraintestinal manifestation in inflammatory bowel disease (IBD). Aims: To look for risk factors of spondyloarthritis among inflammatory bowel disease patients. Methods: We modified the STRIPP questionnaire created for psoriatic patients and we created a rapid questionnaire for rheumatologic investigation in IBD patients (STRII). We submitted the questionnaire to all consecutive patients with a known spondyloarthritis in our centre and to patients with a negative rheumatological diagnosis to find the cut-off value. Finally, we prospectively submitted the STRII questionnaire to all consecutive IBD patients in our centre. Results: A cut-off ≥3 correlated with spondyloarthritis with an AUC = 0.91. The STRII questionnaire was submitted to 1147 IBD patients. Two hundred and forty-four out of 1147 (21.3%) collected a STRII score of ≥3. Female sex (p <.0001) and Crohn’s disease (p =.023) were risk factors. Patients with a history of at least 1 immunosuppressant or biologic drug (p =.002 and p <.0001, respectively) had a higher rate of positivity to STRII questionnaire. Conclusion: Among IBD patients, females, Crohn’s disease, those with a history of at least 1 immunosuppressive or biological therapy are at increased risk of spondyloarthritis.
KW - Arthritis
KW - extra-intestinal manifestations
KW - questionnaire
KW - rheumatologic
KW - STRII
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U2 - 10.1080/00365521.2019.1668052
DO - 10.1080/00365521.2019.1668052
M3 - Article
C2 - 31549896
AN - SCOPUS:85073954649
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
SN - 0036-5521
ER -