Risk factors of suspected spondyloarthritis among inflammatory bowel disease patients

Davide Giuseppe Ribaldone, Marta Vernero, Simone Parisi, Maria Chiara Ditto, Rinaldo Pellicano, Mario Morino, Giorgio Maria Saracco, Enrico Fusaro, Marco Astegiano

Research output: Contribution to journalArticle

Abstract

Background: Occurring in approximately 20–30% of patients, spondyloarthritis is the most common extraintestinal manifestation in inflammatory bowel disease (IBD). Aims: To look for risk factors of spondyloarthritis among inflammatory bowel disease patients. Methods: We modified the STRIPP questionnaire created for psoriatic patients and we created a rapid questionnaire for rheumatologic investigation in IBD patients (STRII). We submitted the questionnaire to all consecutive patients with a known spondyloarthritis in our centre and to patients with a negative rheumatological diagnosis to find the cut-off value. Finally, we prospectively submitted the STRII questionnaire to all consecutive IBD patients in our centre. Results: A cut-off ≥3 correlated with spondyloarthritis with an AUC = 0.91. The STRII questionnaire was submitted to 1147 IBD patients. Two hundred and forty-four out of 1147 (21.3%) collected a STRII score of ≥3. Female sex (p <.0001) and Crohn’s disease (p =.023) were risk factors. Patients with a history of at least 1 immunosuppressant or biologic drug (p =.002 and p <.0001, respectively) had a higher rate of positivity to STRII questionnaire. Conclusion: Among IBD patients, females, Crohn’s disease, those with a history of at least 1 immunosuppressive or biological therapy are at increased risk of spondyloarthritis.

Original languageEnglish
JournalScandinavian Journal of Gastroenterology
DOIs
Publication statusAccepted/In press - Jan 1 2019
Externally publishedYes

Keywords

  • Arthritis
  • extra-intestinal manifestations
  • questionnaire
  • rheumatologic
  • STRII

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Risk factors of suspected spondyloarthritis among inflammatory bowel disease patients'. Together they form a unique fingerprint.

  • Cite this

    Ribaldone, D. G., Vernero, M., Parisi, S., Ditto, M. C., Pellicano, R., Morino, M., Saracco, G. M., Fusaro, E., & Astegiano, M. (Accepted/In press). Risk factors of suspected spondyloarthritis among inflammatory bowel disease patients. Scandinavian Journal of Gastroenterology. https://doi.org/10.1080/00365521.2019.1668052