Risk of arrhythmia in type I myotonic dystrophy

The role of clinical and genetic variables

P. Cudia, P. Bernasconi, R. Chiodelli, F. Mangiola, F. Bellocci, A. Dello Russo, C. Angelini, V. Romeo, P. Melacini, L. Politano, A. Palladino, G. Nigro, G. Siciliano, M. Falorni, M. G. Bongiorni, C. Falcone, R. Mantegazza, L. Morandi

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Objective: To examine the association between the presence of arrhythmia in type 1 myotonic dystrophy (DM1) and clinical-genetic variables, evaluating their role as predictors of the risk of arrhythmia. Methods: 245 patients with genetically proven DM1 underwent clinical and non-invasive cardiological evaluation. Severity of muscular involvement was assessed according to the 5 point Muscular Disability Rating Score (MDRS). Data were analysed by univariate and multi-variate models. Results: 245 patients were examined and cardiac arrhythmias were found in 63 subjects, 40 of whom required a device implant. Statistical analyses revealed that men had more than double the risk of developing arrhythmias compared with women (p = 0.018). Addition of each year of age caused an increased risk of arrhythmia equal to 3% (p = 0.030). Subjects with MDRS 5 had a risk of arrhythmia 12 times higher than patients with MDRS 1-2 (p

Original languageEnglish
Pages (from-to)790-793
Number of pages4
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume80
Issue number7
DOIs
Publication statusPublished - Jul 2009

Fingerprint

Myotonic Dystrophy
Cardiac Arrhythmias
Equipment and Supplies

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Surgery

Cite this

Risk of arrhythmia in type I myotonic dystrophy : The role of clinical and genetic variables. / Cudia, P.; Bernasconi, P.; Chiodelli, R.; Mangiola, F.; Bellocci, F.; Dello Russo, A.; Angelini, C.; Romeo, V.; Melacini, P.; Politano, L.; Palladino, A.; Nigro, G.; Siciliano, G.; Falorni, M.; Bongiorni, M. G.; Falcone, C.; Mantegazza, R.; Morandi, L.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 80, No. 7, 07.2009, p. 790-793.

Research output: Contribution to journalArticle

Cudia, P, Bernasconi, P, Chiodelli, R, Mangiola, F, Bellocci, F, Dello Russo, A, Angelini, C, Romeo, V, Melacini, P, Politano, L, Palladino, A, Nigro, G, Siciliano, G, Falorni, M, Bongiorni, MG, Falcone, C, Mantegazza, R & Morandi, L 2009, 'Risk of arrhythmia in type I myotonic dystrophy: The role of clinical and genetic variables', Journal of Neurology, Neurosurgery and Psychiatry, vol. 80, no. 7, pp. 790-793. https://doi.org/10.1136/jnnp.2008.162594
Cudia, P. ; Bernasconi, P. ; Chiodelli, R. ; Mangiola, F. ; Bellocci, F. ; Dello Russo, A. ; Angelini, C. ; Romeo, V. ; Melacini, P. ; Politano, L. ; Palladino, A. ; Nigro, G. ; Siciliano, G. ; Falorni, M. ; Bongiorni, M. G. ; Falcone, C. ; Mantegazza, R. ; Morandi, L. / Risk of arrhythmia in type I myotonic dystrophy : The role of clinical and genetic variables. In: Journal of Neurology, Neurosurgery and Psychiatry. 2009 ; Vol. 80, No. 7. pp. 790-793.
@article{f6e2aa1a7b644f74957ccb967f810d3e,
title = "Risk of arrhythmia in type I myotonic dystrophy: The role of clinical and genetic variables",
abstract = "Objective: To examine the association between the presence of arrhythmia in type 1 myotonic dystrophy (DM1) and clinical-genetic variables, evaluating their role as predictors of the risk of arrhythmia. Methods: 245 patients with genetically proven DM1 underwent clinical and non-invasive cardiological evaluation. Severity of muscular involvement was assessed according to the 5 point Muscular Disability Rating Score (MDRS). Data were analysed by univariate and multi-variate models. Results: 245 patients were examined and cardiac arrhythmias were found in 63 subjects, 40 of whom required a device implant. Statistical analyses revealed that men had more than double the risk of developing arrhythmias compared with women (p = 0.018). Addition of each year of age caused an increased risk of arrhythmia equal to 3{\%} (p = 0.030). Subjects with MDRS 5 had a risk of arrhythmia 12 times higher than patients with MDRS 1-2 (p",
author = "P. Cudia and P. Bernasconi and R. Chiodelli and F. Mangiola and F. Bellocci and {Dello Russo}, A. and C. Angelini and V. Romeo and P. Melacini and L. Politano and A. Palladino and G. Nigro and G. Siciliano and M. Falorni and Bongiorni, {M. G.} and C. Falcone and R. Mantegazza and L. Morandi",
year = "2009",
month = "7",
doi = "10.1136/jnnp.2008.162594",
language = "English",
volume = "80",
pages = "790--793",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",
number = "7",

}

TY - JOUR

T1 - Risk of arrhythmia in type I myotonic dystrophy

T2 - The role of clinical and genetic variables

AU - Cudia, P.

AU - Bernasconi, P.

AU - Chiodelli, R.

AU - Mangiola, F.

AU - Bellocci, F.

AU - Dello Russo, A.

AU - Angelini, C.

AU - Romeo, V.

AU - Melacini, P.

AU - Politano, L.

AU - Palladino, A.

AU - Nigro, G.

AU - Siciliano, G.

AU - Falorni, M.

AU - Bongiorni, M. G.

AU - Falcone, C.

AU - Mantegazza, R.

AU - Morandi, L.

PY - 2009/7

Y1 - 2009/7

N2 - Objective: To examine the association between the presence of arrhythmia in type 1 myotonic dystrophy (DM1) and clinical-genetic variables, evaluating their role as predictors of the risk of arrhythmia. Methods: 245 patients with genetically proven DM1 underwent clinical and non-invasive cardiological evaluation. Severity of muscular involvement was assessed according to the 5 point Muscular Disability Rating Score (MDRS). Data were analysed by univariate and multi-variate models. Results: 245 patients were examined and cardiac arrhythmias were found in 63 subjects, 40 of whom required a device implant. Statistical analyses revealed that men had more than double the risk of developing arrhythmias compared with women (p = 0.018). Addition of each year of age caused an increased risk of arrhythmia equal to 3% (p = 0.030). Subjects with MDRS 5 had a risk of arrhythmia 12 times higher than patients with MDRS 1-2 (p

AB - Objective: To examine the association between the presence of arrhythmia in type 1 myotonic dystrophy (DM1) and clinical-genetic variables, evaluating their role as predictors of the risk of arrhythmia. Methods: 245 patients with genetically proven DM1 underwent clinical and non-invasive cardiological evaluation. Severity of muscular involvement was assessed according to the 5 point Muscular Disability Rating Score (MDRS). Data were analysed by univariate and multi-variate models. Results: 245 patients were examined and cardiac arrhythmias were found in 63 subjects, 40 of whom required a device implant. Statistical analyses revealed that men had more than double the risk of developing arrhythmias compared with women (p = 0.018). Addition of each year of age caused an increased risk of arrhythmia equal to 3% (p = 0.030). Subjects with MDRS 5 had a risk of arrhythmia 12 times higher than patients with MDRS 1-2 (p

UR - http://www.scopus.com/inward/record.url?scp=67650470235&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67650470235&partnerID=8YFLogxK

U2 - 10.1136/jnnp.2008.162594

DO - 10.1136/jnnp.2008.162594

M3 - Article

VL - 80

SP - 790

EP - 793

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

IS - 7

ER -