Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: An analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) Trial

John W. Eikelboom; Lars Wallentin; Stuart J. Connolly; Mike Ezekowitz; Jeff S. Healey; Jonas Oldgren; Sean Yang; Marco Alings; Scott Kaatz; Stefan H. Hohnloser; Hans Christoph Diener; Maria Grazia Franzosi; Kurt Huber; Paul Reilly; Jeanne Varrone; Salim Yusuf

doi:10.1161/CIRCULATIONAHA.110.004747

Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: An analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) Trial

John W. Eikelboom, Lars Wallentin, Stuart J. Connolly, Mike Ezekowitz, Jeff S. Healey, Jonas Oldgren, Sean Yang, Marco Alings, Scott Kaatz, Stefan H. Hohnloser, Hans Christoph Diener, Maria Grazia Franzosi, Kurt Huber, Paul Reilly, Jeanne Varrone, Salim Yusuf

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

Background-: Dabigatran 150 and 110 mg twice a day and warfarin are effective for stroke prevention in atrial fibrillation. The purpose of this study was to compare their risks of bleeding in the Randomized Evaluation of Long-Term Anticoagulant Therapy (RE-LY) trial. Methods and results-: The RE-LY trial randomized 18 113 patients to receive dabigatran 110 or 150 mg twice a day or warfarin dose adjusted to an international normalized ratio of 2.0 to 3.0 for a median follow-up of 2.0 years. Compared with warfarin, dabigatran 110 mg twice a day was associated with a lower risk of major bleeding (2.87% versus 3.57%; P=0.002), whereas dabigatran 150 mg twice a day was associated with a similar risk of major bleeding (3.31% versus 3.57%; P=0.32). There was a significant treatment-by-age interaction, such that dabigatran 110 mg twice a day compared with warfarin was associated with a lower risk of major bleeding in patients aged

Original language	English
Pages (from-to)	2363-2372
Number of pages	10
Journal	Circulation
Volume	123
Issue number	21
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.110.004747
Publication status	Published - May 31 2011

Keywords

anticoagulants
atrial fibrillation

ASJC Scopus subject areas

Physiology (medical)
Cardiology and Cardiovascular Medicine

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Eikelboom, J. W., Wallentin, L., Connolly, S. J., Ezekowitz, M., Healey, J. S., Oldgren, J., Yang, S., Alings, M., Kaatz, S., Hohnloser, S. H., Diener, H. C., Franzosi, M. G., Huber, K., Reilly, P., Varrone, J., & Yusuf, S. (2011). Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: An analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) Trial. Circulation, 123(21), 2363-2372. https://doi.org/10.1161/CIRCULATIONAHA.110.004747

Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation : An analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) Trial. / Eikelboom, John W.; Wallentin, Lars; Connolly, Stuart J.; Ezekowitz, Mike; Healey, Jeff S.; Oldgren, Jonas; Yang, Sean; Alings, Marco; Kaatz, Scott; Hohnloser, Stefan H.; Diener, Hans Christoph; Franzosi, Maria Grazia; Huber, Kurt; Reilly, Paul; Varrone, Jeanne; Yusuf, Salim.

In: Circulation, Vol. 123, No. 21, 31.05.2011, p. 2363-2372.

Research output: Contribution to journal › Article › peer-review

Eikelboom, JW, Wallentin, L, Connolly, SJ, Ezekowitz, M, Healey, JS, Oldgren, J, Yang, S, Alings, M, Kaatz, S, Hohnloser, SH, Diener, HC, Franzosi, MG, Huber, K, Reilly, P, Varrone, J & Yusuf, S 2011, 'Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: An analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) Trial', Circulation, vol. 123, no. 21, pp. 2363-2372. https://doi.org/10.1161/CIRCULATIONAHA.110.004747

Eikelboom JW, Wallentin L, Connolly SJ, Ezekowitz M, Healey JS, Oldgren J et al. Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: An analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) Trial. Circulation. 2011 May 31;123(21):2363-2372. https://doi.org/10.1161/CIRCULATIONAHA.110.004747

Eikelboom, John W. ; Wallentin, Lars ; Connolly, Stuart J. ; Ezekowitz, Mike ; Healey, Jeff S. ; Oldgren, Jonas ; Yang, Sean ; Alings, Marco ; Kaatz, Scott ; Hohnloser, Stefan H. ; Diener, Hans Christoph ; Franzosi, Maria Grazia ; Huber, Kurt ; Reilly, Paul ; Varrone, Jeanne ; Yusuf, Salim. / Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation : An analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) Trial. In: Circulation. 2011 ; Vol. 123, No. 21. pp. 2363-2372.

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