Risk of cancer following immunosuppression in organ transplant recipients and in HIV-positive individuals in southern Europe

Diego Serraino, Pierluca Piselli, Ghil Busnach, Patrizia Burra, Franco Citterio, Eloisa Arbustini, Umberto Baccarani, Emanuela De Juli, Ubaldo Pozzetto, Stefania Bellelli, Jerry Polesel, Christian Pradier, Luigino Dal Maso, Claudio Angeletti, Maria Patrizia Carrieri, Giovanni Rezza, Silvia Franceschi

Research output: Contribution to journalArticle

Abstract

This investigation highlighted the risk of cancer in 8074 HIV-infected people and in 2875 transplant recipients in Italy and France. Observed and expected numbers of cancer were compared through sex- and age-standardised incidence ratios (SIRs) and 95% confidence intervals (CIs). After 15 years of follow-up, the cumulative probability of cancer was 14.7% in transplant recipients and 13.3% in HIV-positives. The SIRs for all cancers were 9.8 in HIV-positives and 2.2 in transplants. Kaposi's sarcoma (SIR = 451 in HIV-positives, 125 in transplants) and non-Hodgkin lymphoma (SIR = 62 and 11.1, respectively) were the most common cancers. A significantly increased SIR for liver cancer also emerged in both groups. The risk of lung cancer was significantly elevated in heart transplant recipients (SIR = 2.8), and of borderline statistical significance in HIV-positive people (95% CI:0.9-2.8). Immune depression entails a two-fold increased overall risk of cancers, mainly related to cancers associated with a viral aetiology.

Original languageEnglish
Pages (from-to)2117-2123
Number of pages7
JournalEuropean Journal of Cancer
Volume43
Issue number14
DOIs
Publication statusPublished - Sep 2007

Keywords

  • Acquired immunodeficiency
  • Cancer
  • France
  • HIV-infection
  • Italy
  • Organ transplantation
  • SIR

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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  • Cite this

    Serraino, D., Piselli, P., Busnach, G., Burra, P., Citterio, F., Arbustini, E., Baccarani, U., De Juli, E., Pozzetto, U., Bellelli, S., Polesel, J., Pradier, C., Maso, L. D., Angeletti, C., Carrieri, M. P., Rezza, G., & Franceschi, S. (2007). Risk of cancer following immunosuppression in organ transplant recipients and in HIV-positive individuals in southern Europe. European Journal of Cancer, 43(14), 2117-2123. https://doi.org/10.1016/j.ejca.2007.07.015