TY - JOUR
T1 - Risk of cervical HPV infection and prevalence of vaccine-type and other high-risk HPV types among sexually active teens and young women (13-26 years) enrolled in the VALHIDATE study
AU - Orlando, Giovanna
AU - Fasolo, Michela
AU - Mazza, Francesca
AU - Ricci, Elena
AU - Esposito, Susanna
AU - Frati, Elena
AU - Zuccotti, Gian Vincenzo
AU - Cetin, Irene
AU - Gramegna, Maria
AU - Rizzardini, Giuliano
AU - Tanzi, Elisabetta
AU - Antonacci, Maria Concetta
AU - Arcidiacono, Irene
AU - Bianchi, Silvia
AU - Boero, Veronica
AU - Cambiè, Giuseppe
AU - Casolati, Elena
AU - Montinaro, Valentina
AU - Falchetti, Marcella
AU - Martinelli, Marianna
AU - Galli, Carlo
AU - Bertazzoli, Emanuela
AU - Lunghi, Giovanna
AU - Matteelli, Alberto
AU - Tisi, Giancarlo
AU - Villa, Anna Maria
AU - Zanchetta, Nadia
AU - Pogliani, Laura
PY - 2014/4/1
Y1 - 2014/4/1
N2 - HPV vaccination is expected to reduce the incidence of cervical cancer. The greatest and the earliest health gains will be ensured by high vaccine coverage among all susceptible people. The high costs and the risk of a reduced cost/effectiveness ratio in sexually active girls still represent the main obstacles for a more widespread use of HPV vaccination in many countries. Data on the rate, risk factors, and HPV types in sexually active women could provide information for the evaluation of vaccination policies extended to broader age cohorts. Sexually active women aged 13-26 years enrolled in an Italian cohort study were screened for cervical HPV infections; HPV-DNA positive samples were genotyped by InnoLipa HPV Genotyping Extra or by RFLP genotype analysis. Among the 796 women meeting the inclusion criteria, 10.80% (95% CI 8.65-12.96) were HPV-DNA infected. Age >18 years, lifetime sexual partners >1, and history of STIs were associated to higher risk of HPV infection in the multivariable models adjusted for age, lifetime sexual partners, and time of sexual exposure. The global prevalence of the four HPV vaccine-types was 3.02% (95% CI 1.83-4.20) and the cumulative probability of infection from at least one vaccine-type was 12.82% in 26-years-old women and 0.78% in 18-years-old women. Our data confirm most of the previously reported findings on the risk factors for HPV infections. The low prevalence of the HPV vaccine-types found may be useful for the evaluation of the cost/efficacy and the cost/effectiveness of broader immunization programs beyond the 12-years-old cohort.
AB - HPV vaccination is expected to reduce the incidence of cervical cancer. The greatest and the earliest health gains will be ensured by high vaccine coverage among all susceptible people. The high costs and the risk of a reduced cost/effectiveness ratio in sexually active girls still represent the main obstacles for a more widespread use of HPV vaccination in many countries. Data on the rate, risk factors, and HPV types in sexually active women could provide information for the evaluation of vaccination policies extended to broader age cohorts. Sexually active women aged 13-26 years enrolled in an Italian cohort study were screened for cervical HPV infections; HPV-DNA positive samples were genotyped by InnoLipa HPV Genotyping Extra or by RFLP genotype analysis. Among the 796 women meeting the inclusion criteria, 10.80% (95% CI 8.65-12.96) were HPV-DNA infected. Age >18 years, lifetime sexual partners >1, and history of STIs were associated to higher risk of HPV infection in the multivariable models adjusted for age, lifetime sexual partners, and time of sexual exposure. The global prevalence of the four HPV vaccine-types was 3.02% (95% CI 1.83-4.20) and the cumulative probability of infection from at least one vaccine-type was 12.82% in 26-years-old women and 0.78% in 18-years-old women. Our data confirm most of the previously reported findings on the risk factors for HPV infections. The low prevalence of the HPV vaccine-types found may be useful for the evaluation of the cost/efficacy and the cost/effectiveness of broader immunization programs beyond the 12-years-old cohort.
KW - Hpv infection
KW - Hpv vaccine
KW - HR-HPV
KW - Risk factors
KW - Sexually active girls
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U2 - 10.4161/hv.27682
DO - 10.4161/hv.27682
M3 - Article
C2 - 24423757
AN - SCOPUS:84899833123
VL - 10
SP - 986
EP - 994
JO - Human Vaccines and Immunotherapeutics
JF - Human Vaccines and Immunotherapeutics
SN - 2164-5515
IS - 4
ER -