Risk of CIN2 in women with a Pap test without endocervical cells vs. those with a negative Pap test with endocervical cells: A cohort study with 4.5 years of follow-up

Paolo Giorgi Rossi, Diego Baiocchi, Stefano Ciatto, Paola Cariaggi, Daniela Gustinucci, Ilaria Camilli, Ettore Mancini, Gioia Montanari, Adele Caprioglio, Franca Parisio, Claudio Angeloni, Giannina Di Gabriele, Anna Carantoni, Galliano Tinacci, Mario Matteucci, Graziella Pontani, Guido Collina, Maddalena Carmelo, Patrizia Biavati, Patrizia SchincagliaMonica Serafini, Paolo Dalla Palma, Enzo Polla, Aurora Assunta Scarfantoni, Maria Luisa Schiboni, Emanuela Anghinoni

Research output: Contribution to journalArticle

Abstract

Objective: To measure the risk of cervical intraepithelial neoplasia grade 2 or higher (CIN2+) in the 4.5 years following a negative Pap smear with adequate endocervical cells (ECC) (+) or absent/scarce ECC (-). Study Design: A prospective, nonconcurrent study of the archives of 11 Italian population-based screening programs was conducted. Only 25-50-year-old women with a first negative Pap test were included. Results: Women were classified as ECC+ or ECC- and followed for 4.5 years. The end point was the occurrence of a CIN2+ histologic diagnosis. Eligible subjects with negative Pap tests ECC+ and ECC- numbered 469,694 and 20,596, respectively. At least 1 subsequent test was available during follow-up for 335,763 and 11,972 subjects, and 691 and 13 CIN2+ lesions were observed, respectively. The risk of CIN2+ was 2.06 and 1.09 per 1,000 women over 4.5 years, and age-adjusted relative risk associated with ECC-was 0.55 (95% CI 0.28-1.06). Conclusion: Women with a negative Pap ECC- have a lower risk of CIN2+ than women with a negative Pap ECC+ and should repeat screening with the current frequency (3-5 years in Europe), independent of age.

Original languageEnglish
Pages (from-to)265-271
Number of pages7
JournalActa Cytologica
Volume54
Issue number3
Publication statusPublished - 2010

Fingerprint

Papanicolaou Test
Cohort Studies
Cervical Intraepithelial Neoplasia
Prospective Studies

Keywords

  • Cervical cancer
  • Endocervical cells
  • Papanicolaou smear

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Risk of CIN2 in women with a Pap test without endocervical cells vs. those with a negative Pap test with endocervical cells : A cohort study with 4.5 years of follow-up. / Rossi, Paolo Giorgi; Baiocchi, Diego; Ciatto, Stefano; Cariaggi, Paola; Gustinucci, Daniela; Camilli, Ilaria; Mancini, Ettore; Montanari, Gioia; Caprioglio, Adele; Parisio, Franca; Angeloni, Claudio; Di Gabriele, Giannina; Carantoni, Anna; Tinacci, Galliano; Matteucci, Mario; Pontani, Graziella; Collina, Guido; Carmelo, Maddalena; Biavati, Patrizia; Schincaglia, Patrizia; Serafini, Monica; Palma, Paolo Dalla; Polla, Enzo; Scarfantoni, Aurora Assunta; Schiboni, Maria Luisa; Anghinoni, Emanuela.

In: Acta Cytologica, Vol. 54, No. 3, 2010, p. 265-271.

Research output: Contribution to journalArticle

Rossi, PG, Baiocchi, D, Ciatto, S, Cariaggi, P, Gustinucci, D, Camilli, I, Mancini, E, Montanari, G, Caprioglio, A, Parisio, F, Angeloni, C, Di Gabriele, G, Carantoni, A, Tinacci, G, Matteucci, M, Pontani, G, Collina, G, Carmelo, M, Biavati, P, Schincaglia, P, Serafini, M, Palma, PD, Polla, E, Scarfantoni, AA, Schiboni, ML & Anghinoni, E 2010, 'Risk of CIN2 in women with a Pap test without endocervical cells vs. those with a negative Pap test with endocervical cells: A cohort study with 4.5 years of follow-up', Acta Cytologica, vol. 54, no. 3, pp. 265-271.
Rossi, Paolo Giorgi ; Baiocchi, Diego ; Ciatto, Stefano ; Cariaggi, Paola ; Gustinucci, Daniela ; Camilli, Ilaria ; Mancini, Ettore ; Montanari, Gioia ; Caprioglio, Adele ; Parisio, Franca ; Angeloni, Claudio ; Di Gabriele, Giannina ; Carantoni, Anna ; Tinacci, Galliano ; Matteucci, Mario ; Pontani, Graziella ; Collina, Guido ; Carmelo, Maddalena ; Biavati, Patrizia ; Schincaglia, Patrizia ; Serafini, Monica ; Palma, Paolo Dalla ; Polla, Enzo ; Scarfantoni, Aurora Assunta ; Schiboni, Maria Luisa ; Anghinoni, Emanuela. / Risk of CIN2 in women with a Pap test without endocervical cells vs. those with a negative Pap test with endocervical cells : A cohort study with 4.5 years of follow-up. In: Acta Cytologica. 2010 ; Vol. 54, No. 3. pp. 265-271.
@article{7df2a825eb6f4ce085b7d614228ba567,
title = "Risk of CIN2 in women with a Pap test without endocervical cells vs. those with a negative Pap test with endocervical cells: A cohort study with 4.5 years of follow-up",
abstract = "Objective: To measure the risk of cervical intraepithelial neoplasia grade 2 or higher (CIN2+) in the 4.5 years following a negative Pap smear with adequate endocervical cells (ECC) (+) or absent/scarce ECC (-). Study Design: A prospective, nonconcurrent study of the archives of 11 Italian population-based screening programs was conducted. Only 25-50-year-old women with a first negative Pap test were included. Results: Women were classified as ECC+ or ECC- and followed for 4.5 years. The end point was the occurrence of a CIN2+ histologic diagnosis. Eligible subjects with negative Pap tests ECC+ and ECC- numbered 469,694 and 20,596, respectively. At least 1 subsequent test was available during follow-up for 335,763 and 11,972 subjects, and 691 and 13 CIN2+ lesions were observed, respectively. The risk of CIN2+ was 2.06 and 1.09 per 1,000 women over 4.5 years, and age-adjusted relative risk associated with ECC-was 0.55 (95{\%} CI 0.28-1.06). Conclusion: Women with a negative Pap ECC- have a lower risk of CIN2+ than women with a negative Pap ECC+ and should repeat screening with the current frequency (3-5 years in Europe), independent of age.",
keywords = "Cervical cancer, Endocervical cells, Papanicolaou smear",
author = "Rossi, {Paolo Giorgi} and Diego Baiocchi and Stefano Ciatto and Paola Cariaggi and Daniela Gustinucci and Ilaria Camilli and Ettore Mancini and Gioia Montanari and Adele Caprioglio and Franca Parisio and Claudio Angeloni and {Di Gabriele}, Giannina and Anna Carantoni and Galliano Tinacci and Mario Matteucci and Graziella Pontani and Guido Collina and Maddalena Carmelo and Patrizia Biavati and Patrizia Schincaglia and Monica Serafini and Palma, {Paolo Dalla} and Enzo Polla and Scarfantoni, {Aurora Assunta} and Schiboni, {Maria Luisa} and Emanuela Anghinoni",
year = "2010",
language = "English",
volume = "54",
pages = "265--271",
journal = "Acta Cytologica",
issn = "0001-5547",
publisher = "Science Printers and Publishers Inc.",
number = "3",

}

TY - JOUR

T1 - Risk of CIN2 in women with a Pap test without endocervical cells vs. those with a negative Pap test with endocervical cells

T2 - A cohort study with 4.5 years of follow-up

AU - Rossi, Paolo Giorgi

AU - Baiocchi, Diego

AU - Ciatto, Stefano

AU - Cariaggi, Paola

AU - Gustinucci, Daniela

AU - Camilli, Ilaria

AU - Mancini, Ettore

AU - Montanari, Gioia

AU - Caprioglio, Adele

AU - Parisio, Franca

AU - Angeloni, Claudio

AU - Di Gabriele, Giannina

AU - Carantoni, Anna

AU - Tinacci, Galliano

AU - Matteucci, Mario

AU - Pontani, Graziella

AU - Collina, Guido

AU - Carmelo, Maddalena

AU - Biavati, Patrizia

AU - Schincaglia, Patrizia

AU - Serafini, Monica

AU - Palma, Paolo Dalla

AU - Polla, Enzo

AU - Scarfantoni, Aurora Assunta

AU - Schiboni, Maria Luisa

AU - Anghinoni, Emanuela

PY - 2010

Y1 - 2010

N2 - Objective: To measure the risk of cervical intraepithelial neoplasia grade 2 or higher (CIN2+) in the 4.5 years following a negative Pap smear with adequate endocervical cells (ECC) (+) or absent/scarce ECC (-). Study Design: A prospective, nonconcurrent study of the archives of 11 Italian population-based screening programs was conducted. Only 25-50-year-old women with a first negative Pap test were included. Results: Women were classified as ECC+ or ECC- and followed for 4.5 years. The end point was the occurrence of a CIN2+ histologic diagnosis. Eligible subjects with negative Pap tests ECC+ and ECC- numbered 469,694 and 20,596, respectively. At least 1 subsequent test was available during follow-up for 335,763 and 11,972 subjects, and 691 and 13 CIN2+ lesions were observed, respectively. The risk of CIN2+ was 2.06 and 1.09 per 1,000 women over 4.5 years, and age-adjusted relative risk associated with ECC-was 0.55 (95% CI 0.28-1.06). Conclusion: Women with a negative Pap ECC- have a lower risk of CIN2+ than women with a negative Pap ECC+ and should repeat screening with the current frequency (3-5 years in Europe), independent of age.

AB - Objective: To measure the risk of cervical intraepithelial neoplasia grade 2 or higher (CIN2+) in the 4.5 years following a negative Pap smear with adequate endocervical cells (ECC) (+) or absent/scarce ECC (-). Study Design: A prospective, nonconcurrent study of the archives of 11 Italian population-based screening programs was conducted. Only 25-50-year-old women with a first negative Pap test were included. Results: Women were classified as ECC+ or ECC- and followed for 4.5 years. The end point was the occurrence of a CIN2+ histologic diagnosis. Eligible subjects with negative Pap tests ECC+ and ECC- numbered 469,694 and 20,596, respectively. At least 1 subsequent test was available during follow-up for 335,763 and 11,972 subjects, and 691 and 13 CIN2+ lesions were observed, respectively. The risk of CIN2+ was 2.06 and 1.09 per 1,000 women over 4.5 years, and age-adjusted relative risk associated with ECC-was 0.55 (95% CI 0.28-1.06). Conclusion: Women with a negative Pap ECC- have a lower risk of CIN2+ than women with a negative Pap ECC+ and should repeat screening with the current frequency (3-5 years in Europe), independent of age.

KW - Cervical cancer

KW - Endocervical cells

KW - Papanicolaou smear

UR - http://www.scopus.com/inward/record.url?scp=77953225900&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953225900&partnerID=8YFLogxK

M3 - Article

C2 - 20518409

AN - SCOPUS:77953225900

VL - 54

SP - 265

EP - 271

JO - Acta Cytologica

JF - Acta Cytologica

SN - 0001-5547

IS - 3

ER -