Risk of complications in coeliac patients depends on age at diagnosis and type of clinical presentation

Federico Biagi, Annalisa Schiepatti, Gregorio Maiorano, Giacomo Fraternale, Simona Agazzi, Fabiana Zingone, Carolina Ciacci, Umberto Volta, Giacomo Caio, Raffaella Tortora, Catherine Klersy, Gino R Corazza

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Coeliac disease is characterised by an increased mortality mostly due to its complications.

AIMS: To study the risk of developing complications according to clinical presentation and age at diagnosis, a combined retrospective-prospective longitudinal study was performed in three Italian centres.

METHODS: Incidence of complications and mortality rates were calculated using type and age at diagnosis of coeliac disease, sex, and centre of diagnosis as predictors. Patients referred after being found to suffer from coeliac disease elsewhere were excluded.

RESULTS: Between 01/1999 and 06/2015, 2225 adult coeliac patients were directly diagnosed in our centres. 17 of them developed a complication and 29 died. In patients older than 60 years at diagnosis of coeliac disease, the risk of complication is 18 times higher than in patients diagnosed at 18-40 years and 9 times higher than in patients diagnosed at 40-60 years. Classical presentation increases the risk of complications by 7 times compared to non-classical presentation; in asymptomatic patients the risk of complication is virtually absent.

CONCLUSIONS: The risk of developing complications in coeliac patients is linked to age at diagnosis of coeliac disease and type of clinical presentation. Follow-up methods of coeliac patients should be tailored according to these parameters.

Original languageEnglish
Pages (from-to)549-552
Number of pages4
JournalDigestive and Liver Disease
Volume50
Issue number6
DOIs
Publication statusPublished - Jun 2018

Fingerprint

Abdomen
Celiac Disease
Mortality
Longitudinal Studies
Prospective Studies
Incidence

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Celiac Disease/complications
  • Female
  • Humans
  • Incidence
  • Italy/epidemiology
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Prospective Studies
  • Retrospective Studies
  • Risk Assessment
  • Risk Factors
  • Young Adult

Cite this

Risk of complications in coeliac patients depends on age at diagnosis and type of clinical presentation. / Biagi, Federico; Schiepatti, Annalisa; Maiorano, Gregorio; Fraternale, Giacomo; Agazzi, Simona; Zingone, Fabiana; Ciacci, Carolina; Volta, Umberto; Caio, Giacomo; Tortora, Raffaella; Klersy, Catherine; Corazza, Gino R.

In: Digestive and Liver Disease, Vol. 50, No. 6, 06.2018, p. 549-552.

Research output: Contribution to journalArticle

Biagi, F, Schiepatti, A, Maiorano, G, Fraternale, G, Agazzi, S, Zingone, F, Ciacci, C, Volta, U, Caio, G, Tortora, R, Klersy, C & Corazza, GR 2018, 'Risk of complications in coeliac patients depends on age at diagnosis and type of clinical presentation', Digestive and Liver Disease, vol. 50, no. 6, pp. 549-552. https://doi.org/10.1016/j.dld.2017.12.001
Biagi, Federico ; Schiepatti, Annalisa ; Maiorano, Gregorio ; Fraternale, Giacomo ; Agazzi, Simona ; Zingone, Fabiana ; Ciacci, Carolina ; Volta, Umberto ; Caio, Giacomo ; Tortora, Raffaella ; Klersy, Catherine ; Corazza, Gino R. / Risk of complications in coeliac patients depends on age at diagnosis and type of clinical presentation. In: Digestive and Liver Disease. 2018 ; Vol. 50, No. 6. pp. 549-552.
@article{0fd14e031f774833a23581de740ca27f,
title = "Risk of complications in coeliac patients depends on age at diagnosis and type of clinical presentation",
abstract = "BACKGROUND: Coeliac disease is characterised by an increased mortality mostly due to its complications.AIMS: To study the risk of developing complications according to clinical presentation and age at diagnosis, a combined retrospective-prospective longitudinal study was performed in three Italian centres.METHODS: Incidence of complications and mortality rates were calculated using type and age at diagnosis of coeliac disease, sex, and centre of diagnosis as predictors. Patients referred after being found to suffer from coeliac disease elsewhere were excluded.RESULTS: Between 01/1999 and 06/2015, 2225 adult coeliac patients were directly diagnosed in our centres. 17 of them developed a complication and 29 died. In patients older than 60 years at diagnosis of coeliac disease, the risk of complication is 18 times higher than in patients diagnosed at 18-40 years and 9 times higher than in patients diagnosed at 40-60 years. Classical presentation increases the risk of complications by 7 times compared to non-classical presentation; in asymptomatic patients the risk of complication is virtually absent.CONCLUSIONS: The risk of developing complications in coeliac patients is linked to age at diagnosis of coeliac disease and type of clinical presentation. Follow-up methods of coeliac patients should be tailored according to these parameters.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Celiac Disease/complications, Female, Humans, Incidence, Italy/epidemiology, Longitudinal Studies, Male, Middle Aged, Prospective Studies, Retrospective Studies, Risk Assessment, Risk Factors, Young Adult",
author = "Federico Biagi and Annalisa Schiepatti and Gregorio Maiorano and Giacomo Fraternale and Simona Agazzi and Fabiana Zingone and Carolina Ciacci and Umberto Volta and Giacomo Caio and Raffaella Tortora and Catherine Klersy and Corazza, {Gino R}",
note = "Copyright {\circledC} 2017. Published by Elsevier Ltd.",
year = "2018",
month = "6",
doi = "10.1016/j.dld.2017.12.001",
language = "English",
volume = "50",
pages = "549--552",
journal = "Digestive and Liver Disease",
issn = "1590-8658",
publisher = "Elsevier B.V.",
number = "6",

}

TY - JOUR

T1 - Risk of complications in coeliac patients depends on age at diagnosis and type of clinical presentation

AU - Biagi, Federico

AU - Schiepatti, Annalisa

AU - Maiorano, Gregorio

AU - Fraternale, Giacomo

AU - Agazzi, Simona

AU - Zingone, Fabiana

AU - Ciacci, Carolina

AU - Volta, Umberto

AU - Caio, Giacomo

AU - Tortora, Raffaella

AU - Klersy, Catherine

AU - Corazza, Gino R

N1 - Copyright © 2017. Published by Elsevier Ltd.

PY - 2018/6

Y1 - 2018/6

N2 - BACKGROUND: Coeliac disease is characterised by an increased mortality mostly due to its complications.AIMS: To study the risk of developing complications according to clinical presentation and age at diagnosis, a combined retrospective-prospective longitudinal study was performed in three Italian centres.METHODS: Incidence of complications and mortality rates were calculated using type and age at diagnosis of coeliac disease, sex, and centre of diagnosis as predictors. Patients referred after being found to suffer from coeliac disease elsewhere were excluded.RESULTS: Between 01/1999 and 06/2015, 2225 adult coeliac patients were directly diagnosed in our centres. 17 of them developed a complication and 29 died. In patients older than 60 years at diagnosis of coeliac disease, the risk of complication is 18 times higher than in patients diagnosed at 18-40 years and 9 times higher than in patients diagnosed at 40-60 years. Classical presentation increases the risk of complications by 7 times compared to non-classical presentation; in asymptomatic patients the risk of complication is virtually absent.CONCLUSIONS: The risk of developing complications in coeliac patients is linked to age at diagnosis of coeliac disease and type of clinical presentation. Follow-up methods of coeliac patients should be tailored according to these parameters.

AB - BACKGROUND: Coeliac disease is characterised by an increased mortality mostly due to its complications.AIMS: To study the risk of developing complications according to clinical presentation and age at diagnosis, a combined retrospective-prospective longitudinal study was performed in three Italian centres.METHODS: Incidence of complications and mortality rates were calculated using type and age at diagnosis of coeliac disease, sex, and centre of diagnosis as predictors. Patients referred after being found to suffer from coeliac disease elsewhere were excluded.RESULTS: Between 01/1999 and 06/2015, 2225 adult coeliac patients were directly diagnosed in our centres. 17 of them developed a complication and 29 died. In patients older than 60 years at diagnosis of coeliac disease, the risk of complication is 18 times higher than in patients diagnosed at 18-40 years and 9 times higher than in patients diagnosed at 40-60 years. Classical presentation increases the risk of complications by 7 times compared to non-classical presentation; in asymptomatic patients the risk of complication is virtually absent.CONCLUSIONS: The risk of developing complications in coeliac patients is linked to age at diagnosis of coeliac disease and type of clinical presentation. Follow-up methods of coeliac patients should be tailored according to these parameters.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Celiac Disease/complications

KW - Female

KW - Humans

KW - Incidence

KW - Italy/epidemiology

KW - Longitudinal Studies

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - Retrospective Studies

KW - Risk Assessment

KW - Risk Factors

KW - Young Adult

U2 - 10.1016/j.dld.2017.12.001

DO - 10.1016/j.dld.2017.12.001

M3 - Article

VL - 50

SP - 549

EP - 552

JO - Digestive and Liver Disease

JF - Digestive and Liver Disease

SN - 1590-8658

IS - 6

ER -