Risk of congenital anomalies around a municipal solid waste incinerator: A GIS-based case-control study

Marco Vinceti, Carlotta Malagoli, Sara Fabbi, Sergio Teggi, Rossella Rodolfi, Livia Garavelli, Gianni Astolfi, Francesca Rivieri

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: Waste incineration releases into the environment toxic substances having a teratogenic potential, but little epidemiologic evidence is available on this topic. We aimed at examining the relation between exposure to the emissions from a municipal solid waste incinerator and risk of birth defects in a northern Italy community, using Geographical Information System (GIS) data to estimate exposure and a population-based case-control study design. By modelling the incinerator emissions, we defined in the GIS three areas of increasing exposure according to predicted dioxins concentrations. We mapped the 228 births and induced abortions with diagnosis of congenital anomalies observed during the 1998-2006 period, together with a corresponding series of control births matched for year and hospital of birth/abortion as well as maternal age, using maternal address in the first three months of pregnancy to geocode cases and controls. Results: Among women residing in the areas with medium and high exposure, prevalence of anomalies in the offspring was substantially comparable to that observed in the control population, nor dose-response relations for any of the major categories of birth defects emerged. Furthermore, odds ratio for congenital anomalies did not decrease during a prolonged shut-down period of the plant. Conclusion: Overall, these findings do not lend support to the hypothesis that the environmental contamination occurring around an incineration plant such as that examined in this study may induce major teratogenic effects.

Original languageEnglish
Article number8
JournalInternational Journal of Health Geographics
Volume8
Issue number1
DOIs
Publication statusPublished - Feb 10 2009

Fingerprint

Incineration
Solid Waste
Geographic Information Systems
Refuse incinerators
Municipal solid waste
Case-Control Studies
Information systems
Geographic Mapping
Parturition
Dioxins
Induced Abortion
Poisons
Maternal Age
Contraception
Italy
Population
Odds Ratio
Mothers
Pregnancy
Defects

ASJC Scopus subject areas

  • Computer Science(all)
  • Business, Management and Accounting(all)
  • Public Health, Environmental and Occupational Health

Cite this

Risk of congenital anomalies around a municipal solid waste incinerator : A GIS-based case-control study. / Vinceti, Marco; Malagoli, Carlotta; Fabbi, Sara; Teggi, Sergio; Rodolfi, Rossella; Garavelli, Livia; Astolfi, Gianni; Rivieri, Francesca.

In: International Journal of Health Geographics, Vol. 8, No. 1, 8, 10.02.2009.

Research output: Contribution to journalArticle

Vinceti, M, Malagoli, C, Fabbi, S, Teggi, S, Rodolfi, R, Garavelli, L, Astolfi, G & Rivieri, F 2009, 'Risk of congenital anomalies around a municipal solid waste incinerator: A GIS-based case-control study', International Journal of Health Geographics, vol. 8, no. 1, 8. https://doi.org/10.1186/1476-072X-8-8
Vinceti, Marco ; Malagoli, Carlotta ; Fabbi, Sara ; Teggi, Sergio ; Rodolfi, Rossella ; Garavelli, Livia ; Astolfi, Gianni ; Rivieri, Francesca. / Risk of congenital anomalies around a municipal solid waste incinerator : A GIS-based case-control study. In: International Journal of Health Geographics. 2009 ; Vol. 8, No. 1.
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