Risk of congenital disease in 46 infected fetuses according to gestational age of primary human cytomegalovirus infection in the mother

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Abstract

Given the difficulty in establishing the exact time of HCMV transmission from mother to fetus, HCMV intrauterine infection was investigated in 46 infected fetuses/newborns by correlating maternal and fetal parameters with clinical outcome according to the time interval between the onset of maternal infection and prenatal diagnosis. In detail, 17/28 (60.7%) asymptomatic and 18/18 (100%) symptomatic fetuses/newborns were infected as a consequence of a primary maternal HCMV infection acquired ≤8 weeks of gestational age, while 11/28 (39.3%) asymptomatic and 0/18 (0%) symptomatic fetuses/newborns were congenitally infected when maternal infection was acquired >8 weeks' gestation. Symptomatic fetal infections appeared to be associated with a maternal primary infection occurring at ≤ 8 weeks' gestation. Cordocentesis performed at 20 weeks' gestation should be restricted to high risk infected fetuses.

Original languageEnglish
Pages (from-to)120-126
Number of pages7
JournalJournal of Medical Virology
Volume88
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

Keywords

  • Amniocentesis
  • Congenital disease
  • Human cytomegalovirus
  • Maternal infection

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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