Risk of congenital disease in 46 infected fetuses according to gestational age of primary human cytomegalovirus infection in the mother

Research output: Contribution to journalArticle

Abstract

Given the difficulty in establishing the exact time of HCMV transmission from mother to fetus, HCMV intrauterine infection was investigated in 46 infected fetuses/newborns by correlating maternal and fetal parameters with clinical outcome according to the time interval between the onset of maternal infection and prenatal diagnosis. In detail, 17/28 (60.7%) asymptomatic and 18/18 (100%) symptomatic fetuses/newborns were infected as a consequence of a primary maternal HCMV infection acquired ≤8 weeks of gestational age, while 11/28 (39.3%) asymptomatic and 0/18 (0%) symptomatic fetuses/newborns were congenitally infected when maternal infection was acquired >8 weeks' gestation. Symptomatic fetal infections appeared to be associated with a maternal primary infection occurring at ≤ 8 weeks' gestation. Cordocentesis performed at 20 weeks' gestation should be restricted to high risk infected fetuses.

Original languageEnglish
Pages (from-to)120-126
Number of pages7
JournalJournal of Medical Virology
Volume88
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

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Cytomegalovirus Infections
Gestational Age
Fetus
Mothers
Infection
Pregnancy
Cordocentesis
Prenatal Diagnosis

Keywords

  • Amniocentesis
  • Congenital disease
  • Human cytomegalovirus
  • Maternal infection

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

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title = "Risk of congenital disease in 46 infected fetuses according to gestational age of primary human cytomegalovirus infection in the mother",
abstract = "Given the difficulty in establishing the exact time of HCMV transmission from mother to fetus, HCMV intrauterine infection was investigated in 46 infected fetuses/newborns by correlating maternal and fetal parameters with clinical outcome according to the time interval between the onset of maternal infection and prenatal diagnosis. In detail, 17/28 (60.7{\%}) asymptomatic and 18/18 (100{\%}) symptomatic fetuses/newborns were infected as a consequence of a primary maternal HCMV infection acquired ≤8 weeks of gestational age, while 11/28 (39.3{\%}) asymptomatic and 0/18 (0{\%}) symptomatic fetuses/newborns were congenitally infected when maternal infection was acquired >8 weeks' gestation. Symptomatic fetal infections appeared to be associated with a maternal primary infection occurring at ≤ 8 weeks' gestation. Cordocentesis performed at 20 weeks' gestation should be restricted to high risk infected fetuses.",
keywords = "Amniocentesis, Congenital disease, Human cytomegalovirus, Maternal infection",
author = "Maurizio Zavattoni and Mariangela Rustico and Beatrice Tassis and Giuseppina Lombardi and Milena Furione and Antonio Piralla and Fausto Baldanti",
year = "2016",
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T1 - Risk of congenital disease in 46 infected fetuses according to gestational age of primary human cytomegalovirus infection in the mother

AU - Zavattoni, Maurizio

AU - Rustico, Mariangela

AU - Tassis, Beatrice

AU - Lombardi, Giuseppina

AU - Furione, Milena

AU - Piralla, Antonio

AU - Baldanti, Fausto

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Given the difficulty in establishing the exact time of HCMV transmission from mother to fetus, HCMV intrauterine infection was investigated in 46 infected fetuses/newborns by correlating maternal and fetal parameters with clinical outcome according to the time interval between the onset of maternal infection and prenatal diagnosis. In detail, 17/28 (60.7%) asymptomatic and 18/18 (100%) symptomatic fetuses/newborns were infected as a consequence of a primary maternal HCMV infection acquired ≤8 weeks of gestational age, while 11/28 (39.3%) asymptomatic and 0/18 (0%) symptomatic fetuses/newborns were congenitally infected when maternal infection was acquired >8 weeks' gestation. Symptomatic fetal infections appeared to be associated with a maternal primary infection occurring at ≤ 8 weeks' gestation. Cordocentesis performed at 20 weeks' gestation should be restricted to high risk infected fetuses.

AB - Given the difficulty in establishing the exact time of HCMV transmission from mother to fetus, HCMV intrauterine infection was investigated in 46 infected fetuses/newborns by correlating maternal and fetal parameters with clinical outcome according to the time interval between the onset of maternal infection and prenatal diagnosis. In detail, 17/28 (60.7%) asymptomatic and 18/18 (100%) symptomatic fetuses/newborns were infected as a consequence of a primary maternal HCMV infection acquired ≤8 weeks of gestational age, while 11/28 (39.3%) asymptomatic and 0/18 (0%) symptomatic fetuses/newborns were congenitally infected when maternal infection was acquired >8 weeks' gestation. Symptomatic fetal infections appeared to be associated with a maternal primary infection occurring at ≤ 8 weeks' gestation. Cordocentesis performed at 20 weeks' gestation should be restricted to high risk infected fetuses.

KW - Amniocentesis

KW - Congenital disease

KW - Human cytomegalovirus

KW - Maternal infection

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