Abstract
Given the difficulty in establishing the exact time of HCMV transmission from mother to fetus, HCMV intrauterine infection was investigated in 46 infected fetuses/newborns by correlating maternal and fetal parameters with clinical outcome according to the time interval between the onset of maternal infection and prenatal diagnosis. In detail, 17/28 (60.7%) asymptomatic and 18/18 (100%) symptomatic fetuses/newborns were infected as a consequence of a primary maternal HCMV infection acquired ≤8 weeks of gestational age, while 11/28 (39.3%) asymptomatic and 0/18 (0%) symptomatic fetuses/newborns were congenitally infected when maternal infection was acquired >8 weeks' gestation. Symptomatic fetal infections appeared to be associated with a maternal primary infection occurring at ≤ 8 weeks' gestation. Cordocentesis performed at 20 weeks' gestation should be restricted to high risk infected fetuses.
| Original language | English |
|---|---|
| Pages (from-to) | 120-126 |
| Number of pages | 7 |
| Journal | Journal of Medical Virology |
| Volume | 88 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2016 |
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Keywords
- Amniocentesis
- Congenital disease
- Human cytomegalovirus
- Maternal infection
ASJC Scopus subject areas
- Virology
- Infectious Diseases
Cite this
Risk of congenital disease in 46 infected fetuses according to gestational age of primary human cytomegalovirus infection in the mother. / Zavattoni, Maurizio; Rustico, Mariangela; Tassis, Beatrice; Lombardi, Giuseppina; Furione, Milena; Piralla, Antonio; Baldanti, Fausto.
In: Journal of Medical Virology, Vol. 88, No. 1, 01.01.2016, p. 120-126.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Risk of congenital disease in 46 infected fetuses according to gestational age of primary human cytomegalovirus infection in the mother
AU - Zavattoni, Maurizio
AU - Rustico, Mariangela
AU - Tassis, Beatrice
AU - Lombardi, Giuseppina
AU - Furione, Milena
AU - Piralla, Antonio
AU - Baldanti, Fausto
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Given the difficulty in establishing the exact time of HCMV transmission from mother to fetus, HCMV intrauterine infection was investigated in 46 infected fetuses/newborns by correlating maternal and fetal parameters with clinical outcome according to the time interval between the onset of maternal infection and prenatal diagnosis. In detail, 17/28 (60.7%) asymptomatic and 18/18 (100%) symptomatic fetuses/newborns were infected as a consequence of a primary maternal HCMV infection acquired ≤8 weeks of gestational age, while 11/28 (39.3%) asymptomatic and 0/18 (0%) symptomatic fetuses/newborns were congenitally infected when maternal infection was acquired >8 weeks' gestation. Symptomatic fetal infections appeared to be associated with a maternal primary infection occurring at ≤ 8 weeks' gestation. Cordocentesis performed at 20 weeks' gestation should be restricted to high risk infected fetuses.
AB - Given the difficulty in establishing the exact time of HCMV transmission from mother to fetus, HCMV intrauterine infection was investigated in 46 infected fetuses/newborns by correlating maternal and fetal parameters with clinical outcome according to the time interval between the onset of maternal infection and prenatal diagnosis. In detail, 17/28 (60.7%) asymptomatic and 18/18 (100%) symptomatic fetuses/newborns were infected as a consequence of a primary maternal HCMV infection acquired ≤8 weeks of gestational age, while 11/28 (39.3%) asymptomatic and 0/18 (0%) symptomatic fetuses/newborns were congenitally infected when maternal infection was acquired >8 weeks' gestation. Symptomatic fetal infections appeared to be associated with a maternal primary infection occurring at ≤ 8 weeks' gestation. Cordocentesis performed at 20 weeks' gestation should be restricted to high risk infected fetuses.
KW - Amniocentesis
KW - Congenital disease
KW - Human cytomegalovirus
KW - Maternal infection
UR - http://www.scopus.com/inward/record.url?scp=84945487783&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84945487783&partnerID=8YFLogxK
U2 - 10.1002/jmv.24313
DO - 10.1002/jmv.24313
M3 - Article
C2 - 26118464
AN - SCOPUS:84945487783
VL - 88
SP - 120
EP - 126
JO - Journal of Medical Virology
JF - Journal of Medical Virology
SN - 0146-6615
IS - 1
ER -