Abstract
Given the difficulty in establishing the exact time of HCMV transmission from mother to fetus, HCMV intrauterine infection was investigated in 46 infected fetuses/newborns by correlating maternal and fetal parameters with clinical outcome according to the time interval between the onset of maternal infection and prenatal diagnosis. In detail, 17/28 (60.7%) asymptomatic and 18/18 (100%) symptomatic fetuses/newborns were infected as a consequence of a primary maternal HCMV infection acquired ≤8 weeks of gestational age, while 11/28 (39.3%) asymptomatic and 0/18 (0%) symptomatic fetuses/newborns were congenitally infected when maternal infection was acquired >8 weeks' gestation. Symptomatic fetal infections appeared to be associated with a maternal primary infection occurring at ≤ 8 weeks' gestation. Cordocentesis performed at 20 weeks' gestation should be restricted to high risk infected fetuses.
Original language | English |
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Pages (from-to) | 120-126 |
Number of pages | 7 |
Journal | Journal of Medical Virology |
Volume | 88 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 1 2016 |
Keywords
- Amniocentesis
- Congenital disease
- Human cytomegalovirus
- Maternal infection
ASJC Scopus subject areas
- Virology
- Infectious Diseases