Risk of Congenital Heart Defects in Relatives of Patients With Atrioventricular Canal

Maria Cristina Digilio, Bruno Marino, Maria Paola Cicini, Aldo Giannotti, Roberto Formigari, Bruno Dallapiccola

Research output: Contribution to journalArticlepeer-review


Objective. —To investigate the overall occurrence of congenital heart disease in 103 pedigrees with a proband affected with atrioventricular canal. Design. —Family study of patient series. Setting. —Department of Pediatric Cardiology, Bambino Gesu' Hospital, Rome, Italy. Participants. —One hundred three consecutive patients with atrioventricular canal and normal karyotype and their first- and second-degree relatives. Interventions. —None. Measurements/Main Results. —In 12 pedigrees (11.7%), one or more relatives had concordant or discordant congenital heart disease. Congenital heart disease occurred in four (1.9%) of the 206 parents of probands, in four (3.6%) of the 111 siblings, and in five (0.8%) of the 644 uncles or aunts. None of the grandparents had congenital heart disease. Atrioventricular canal affected several family members in five pedigrees. Conclusions. —Familial aggregation of atrioventricular canal in several pedigrees requires careful collection of family histories, accurate cardiologic evaluation of the first-and second-degree relatives of the probands, and fetal echocardiography in all pregnant women in at-risk families.

Original languageEnglish
Pages (from-to)1295-1297
Number of pages3
JournalAmerican Journal of Diseases of Children
Issue number12
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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