Risk of HCC: Genetic heterogeneity and complex genetics

Research output: Contribution to journalArticlepeer-review

Abstract

Hepatocellular carcinoma (HCC) is a common form of cancer that arises from hepatocytes and whose risk may be affected by several known environmental factors, including hepatitis viruses, alcohol, cigarette smoking, and others. Rare monogenic syndromes, such as alpha1-antitrypsin deficiency, glycogen storage disease type I, hemochromatosis, acute intermittent and cutanea tarda porphyria, as well as hereditary tyrosinemia type I are associated with a high risk of HCC. Several common conditions or diseases inherited as polygenic traits e.g. autoimmune hepatitis, type 2 diabetes, a family history of HCC, hypothyroidism, and non-alcoholic steatohepatitis also show an increased risk of HCC compared to the general population. Overall, the genetic susceptibility to HCC is characterized by a genetic heterogeneity; a high individual risk of HCC may thus be caused by several unlinked single gene defects, whose carriers are rare in the general population, or by more common conditions inherited by complex genetics.

Original languageEnglish
Pages (from-to)252-257
Number of pages6
JournalJournal of Hepatology
Volume52
Issue number2
DOIs
Publication statusPublished - Feb 2010

Keywords

  • Cirrhosis
  • Glycogen storage disease
  • Hemochromatosis
  • Hepatitis
  • Non-alcoholic steatohepatitis
  • Porphyrias
  • Tyrosinemia type I

ASJC Scopus subject areas

  • Hepatology

Fingerprint Dive into the research topics of 'Risk of HCC: Genetic heterogeneity and complex genetics'. Together they form a unique fingerprint.

Cite this