Risk of hepatocellular carcinoma in relation to ABO blood type

Massimo Iavarone, Cristina Della Corte, Claudio Pelucchi, Maurizio Marconi, Roberta Trotti, Michela Triolo, Matteo Angelo Manini, Carlo La Vecchia

Research output: Contribution to journalArticlepeer-review


Background: Mortality and incidence rates of hepatocellular carcinoma (HCC) parallel the geographical distribution of hepatitis B and C viruses among the general population, however genetic factors modulate individual cancer risk. Aims: ABO blood type, as a genetic marker, has previously been associated with the risk of several malignancies; we aimed to evaluate whether an association exists with HCC. Methods: This is a retrospective case-control study based on ABO distribution in 194 patients with HCC, compared with 215 decompensated cirrhotics without HCC listed for liver transplantation, and 90,322 healthy blood donors. Results: In patients with HCC, prevalence of blood type O was 35%, vs. 44% in cirrhotics (OR: 0.67, 95% CI 0.45-0.99; p = 0.046) and 45% in blood donors (OR: 0.65, 95% CI 0.48-0.88; p = 0.004). Conclusions: ABO blood type non-O is associated with higher risk of hepatocellular carcinoma, compared to cirrhotics without HCC and healthy subjects.

Original languageEnglish
Pages (from-to)94-96
Number of pages3
JournalDigestive and Liver Disease
Issue number1
Publication statusPublished - Jan 1 2016


  • ABO
  • Blood type
  • Cirrhosis
  • Hepatocellular carcinoma

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology


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