Risk of low bone density in women attending menopause clinics in Italy

D. De Aloysio, P. Di Donato, N. A. Giulini, Bacchi Modena, G. Cicchetti, G. Comitini, G. Gentile, P. Cristiani, A. Careccia, E. Esposito, C. Gigli, G. Mandruzzato, F. Petraglia, F. Bertelli, G. Del Frate, S. Garofalo, L. Marino, M. R. Costa, S. Quaranta, C. M. BossiP. Amantea, U. Omodei, M. Vaccari, M. Luerti, F. Repetti, G. Zandonini, F. Raspagliesi, F. Dolci, V. Zacchi, S. Bennici, G. Polizzotti, S. Bottino, F. Raffaelli, C. Minervini, D. Colombo, C. Belloni, A. Viani, G. Cecchini, S. Winkler, B. A. Samaja, E. Pasinetti, M. Penotti, C. Malanetto, M. Massobrio, C. Campagnoli, G. Dolfin, P. Tartaglino, D. Mossotto, P. Pesando, L. Pacilli, P. D. Rattazzi, E. Arisi, M. Gamper, D. Salvatores, E. Bocchin, G. Stellin, G. Meli, V. Azzini, F. Tirozzi, G. Buoso, R. Fraioli, V. Marsoni, C. Cetera, R. Sposetti, U. Bellati, C. Angeloni, M. Buonerba, S. Garzarelli, C. Santilli, M. Mucci, Q. Di Nisio, L. Falasca, D. Ferrante, E. Cirese, P. A. Todaro, C. Romanini, L. Spagnuolo, A. Lanzone, C. Donadio, M. Fabiani, E. Baldaccini, S. Votano, G. B. Serra, P. Bellardini, L. Massacesi, G. Donini, R. A. Genazzani, G. Scarselli, P. Curiel, V. De Leo, A. Melani, V. Levi D'Ancona, G. Giarrè, E. Di Gioia, P. Ciccarelli, C. Donati Sarti, G. Balsotti, P. Pupita, F. Parazzini

Research output: Contribution to journalArticle

Abstract

Objective: In order to offer data on the epidemiological profile of women with low bone density (LBD), we have considered information collected in the framework of a large cross-sectional study conducted on women around menopause attending a network of first level outpatients menopause clinics in Italy. Methods: During 1997 and 2000, a large cross sectional study was conducted on the characteristics of women around menopause attending a network of first level outpatients menopause clinics in Italy for general counseling about menopause or treatment of menopausal symptoms. Eligible for the study were women consecutively observed during the study period. Up to March 2000 a total of 42 464 women (mean age 53 years) were observed at the 268 participating centers. Bone mass density was measured in 25 113 cases, which are considered in this analysis. LBD (i.e. osteopenia or osteoporosis) was defined according to WHO classification. Results: The frequency of LBD increased with age: in comparison with women aged ≤ 51 years, the odds ratio (OR) of LBD was 1.5 and 2.2, respectively, in women aged 52-55 and ≥ 56. No association emerged between LBD and parity: in comparison with nulliparae, the OR of LBD were 1.1 and 1.0, respectively, in women reported 1 or 2 or more full term pregnancies. Smokers were at increased risk of LBD, the corresponding OR being for smokers, in comparison with non smokers, 1.2 (95% confidence interval, CI, 1.1-1.3). In comparison with women in the lower tertile of body mass index, the OR of LBD decreased in subsequent tertiles, being, respectively, 0.9 and 0.7 in the middle and highest tertile. The OR of LBD was 2.2 in postmenopausal women, in comparison with premenopausal ones and the OR decreased increasing age at menopause. Ever OC users were at slightly decreased risk of LBD: in comparison with never OC users, the OR was 0.9 (95% CI 0.8-1.0) in ever OC users. Conclusion: The results of this large study confirm, in a Souther European population, the association of age at menopause and body mass on the risk of LBD, and suggest that ever OC women are at decreased risk of LBD.

Original languageEnglish
Pages (from-to)105-111
Number of pages7
JournalMaturitas
Volume42
Issue number2
DOIs
Publication statusPublished - Jun 25 2002

Fingerprint

Menopause
Bone Density
Italy
Bone
Odds Ratio
Ambulatory Care Facilities
Cross-Sectional Studies
Metabolic Bone Diseases
Parity
Osteoporosis
Counseling
Body Mass Index
Confidence Intervals

Keywords

  • Low bone density (LBD)
  • Postmenopausal
  • Risk factors

ASJC Scopus subject areas

  • Ageing
  • Obstetrics and Gynaecology

Cite this

De Aloysio, D., Di Donato, P., Giulini, N. A., Modena, B., Cicchetti, G., Comitini, G., ... Parazzini, F. (2002). Risk of low bone density in women attending menopause clinics in Italy. Maturitas, 42(2), 105-111. https://doi.org/10.1016/S0378-5122(02)00034-8

Risk of low bone density in women attending menopause clinics in Italy. / De Aloysio, D.; Di Donato, P.; Giulini, N. A.; Modena, Bacchi; Cicchetti, G.; Comitini, G.; Gentile, G.; Cristiani, P.; Careccia, A.; Esposito, E.; Gigli, C.; Mandruzzato, G.; Petraglia, F.; Bertelli, F.; Del Frate, G.; Garofalo, S.; Marino, L.; Costa, M. R.; Quaranta, S.; Bossi, C. M.; Amantea, P.; Omodei, U.; Vaccari, M.; Luerti, M.; Repetti, F.; Zandonini, G.; Raspagliesi, F.; Dolci, F.; Zacchi, V.; Bennici, S.; Polizzotti, G.; Bottino, S.; Raffaelli, F.; Minervini, C.; Colombo, D.; Belloni, C.; Viani, A.; Cecchini, G.; Winkler, S.; Samaja, B. A.; Pasinetti, E.; Penotti, M.; Malanetto, C.; Massobrio, M.; Campagnoli, C.; Dolfin, G.; Tartaglino, P.; Mossotto, D.; Pesando, P.; Pacilli, L.; Rattazzi, P. D.; Arisi, E.; Gamper, M.; Salvatores, D.; Bocchin, E.; Stellin, G.; Meli, G.; Azzini, V.; Tirozzi, F.; Buoso, G.; Fraioli, R.; Marsoni, V.; Cetera, C.; Sposetti, R.; Bellati, U.; Angeloni, C.; Buonerba, M.; Garzarelli, S.; Santilli, C.; Mucci, M.; Di Nisio, Q.; Falasca, L.; Ferrante, D.; Cirese, E.; Todaro, P. A.; Romanini, C.; Spagnuolo, L.; Lanzone, A.; Donadio, C.; Fabiani, M.; Baldaccini, E.; Votano, S.; Serra, G. B.; Bellardini, P.; Massacesi, L.; Donini, G.; Genazzani, R. A.; Scarselli, G.; Curiel, P.; De Leo, V.; Melani, A.; Levi D'Ancona, V.; Giarrè, G.; Di Gioia, E.; Ciccarelli, P.; Donati Sarti, C.; Balsotti, G.; Pupita, P.; Parazzini, F.

In: Maturitas, Vol. 42, No. 2, 25.06.2002, p. 105-111.

Research output: Contribution to journalArticle

De Aloysio, D, Di Donato, P, Giulini, NA, Modena, B, Cicchetti, G, Comitini, G, Gentile, G, Cristiani, P, Careccia, A, Esposito, E, Gigli, C, Mandruzzato, G, Petraglia, F, Bertelli, F, Del Frate, G, Garofalo, S, Marino, L, Costa, MR, Quaranta, S, Bossi, CM, Amantea, P, Omodei, U, Vaccari, M, Luerti, M, Repetti, F, Zandonini, G, Raspagliesi, F, Dolci, F, Zacchi, V, Bennici, S, Polizzotti, G, Bottino, S, Raffaelli, F, Minervini, C, Colombo, D, Belloni, C, Viani, A, Cecchini, G, Winkler, S, Samaja, BA, Pasinetti, E, Penotti, M, Malanetto, C, Massobrio, M, Campagnoli, C, Dolfin, G, Tartaglino, P, Mossotto, D, Pesando, P, Pacilli, L, Rattazzi, PD, Arisi, E, Gamper, M, Salvatores, D, Bocchin, E, Stellin, G, Meli, G, Azzini, V, Tirozzi, F, Buoso, G, Fraioli, R, Marsoni, V, Cetera, C, Sposetti, R, Bellati, U, Angeloni, C, Buonerba, M, Garzarelli, S, Santilli, C, Mucci, M, Di Nisio, Q, Falasca, L, Ferrante, D, Cirese, E, Todaro, PA, Romanini, C, Spagnuolo, L, Lanzone, A, Donadio, C, Fabiani, M, Baldaccini, E, Votano, S, Serra, GB, Bellardini, P, Massacesi, L, Donini, G, Genazzani, RA, Scarselli, G, Curiel, P, De Leo, V, Melani, A, Levi D'Ancona, V, Giarrè, G, Di Gioia, E, Ciccarelli, P, Donati Sarti, C, Balsotti, G, Pupita, P & Parazzini, F 2002, 'Risk of low bone density in women attending menopause clinics in Italy', Maturitas, vol. 42, no. 2, pp. 105-111. https://doi.org/10.1016/S0378-5122(02)00034-8
De Aloysio D, Di Donato P, Giulini NA, Modena B, Cicchetti G, Comitini G et al. Risk of low bone density in women attending menopause clinics in Italy. Maturitas. 2002 Jun 25;42(2):105-111. https://doi.org/10.1016/S0378-5122(02)00034-8
De Aloysio, D. ; Di Donato, P. ; Giulini, N. A. ; Modena, Bacchi ; Cicchetti, G. ; Comitini, G. ; Gentile, G. ; Cristiani, P. ; Careccia, A. ; Esposito, E. ; Gigli, C. ; Mandruzzato, G. ; Petraglia, F. ; Bertelli, F. ; Del Frate, G. ; Garofalo, S. ; Marino, L. ; Costa, M. R. ; Quaranta, S. ; Bossi, C. M. ; Amantea, P. ; Omodei, U. ; Vaccari, M. ; Luerti, M. ; Repetti, F. ; Zandonini, G. ; Raspagliesi, F. ; Dolci, F. ; Zacchi, V. ; Bennici, S. ; Polizzotti, G. ; Bottino, S. ; Raffaelli, F. ; Minervini, C. ; Colombo, D. ; Belloni, C. ; Viani, A. ; Cecchini, G. ; Winkler, S. ; Samaja, B. A. ; Pasinetti, E. ; Penotti, M. ; Malanetto, C. ; Massobrio, M. ; Campagnoli, C. ; Dolfin, G. ; Tartaglino, P. ; Mossotto, D. ; Pesando, P. ; Pacilli, L. ; Rattazzi, P. D. ; Arisi, E. ; Gamper, M. ; Salvatores, D. ; Bocchin, E. ; Stellin, G. ; Meli, G. ; Azzini, V. ; Tirozzi, F. ; Buoso, G. ; Fraioli, R. ; Marsoni, V. ; Cetera, C. ; Sposetti, R. ; Bellati, U. ; Angeloni, C. ; Buonerba, M. ; Garzarelli, S. ; Santilli, C. ; Mucci, M. ; Di Nisio, Q. ; Falasca, L. ; Ferrante, D. ; Cirese, E. ; Todaro, P. A. ; Romanini, C. ; Spagnuolo, L. ; Lanzone, A. ; Donadio, C. ; Fabiani, M. ; Baldaccini, E. ; Votano, S. ; Serra, G. B. ; Bellardini, P. ; Massacesi, L. ; Donini, G. ; Genazzani, R. A. ; Scarselli, G. ; Curiel, P. ; De Leo, V. ; Melani, A. ; Levi D'Ancona, V. ; Giarrè, G. ; Di Gioia, E. ; Ciccarelli, P. ; Donati Sarti, C. ; Balsotti, G. ; Pupita, P. ; Parazzini, F. / Risk of low bone density in women attending menopause clinics in Italy. In: Maturitas. 2002 ; Vol. 42, No. 2. pp. 105-111.
@article{5a1d1a20f6c84ae1b86a246993bc125a,
title = "Risk of low bone density in women attending menopause clinics in Italy",
abstract = "Objective: In order to offer data on the epidemiological profile of women with low bone density (LBD), we have considered information collected in the framework of a large cross-sectional study conducted on women around menopause attending a network of first level outpatients menopause clinics in Italy. Methods: During 1997 and 2000, a large cross sectional study was conducted on the characteristics of women around menopause attending a network of first level outpatients menopause clinics in Italy for general counseling about menopause or treatment of menopausal symptoms. Eligible for the study were women consecutively observed during the study period. Up to March 2000 a total of 42 464 women (mean age 53 years) were observed at the 268 participating centers. Bone mass density was measured in 25 113 cases, which are considered in this analysis. LBD (i.e. osteopenia or osteoporosis) was defined according to WHO classification. Results: The frequency of LBD increased with age: in comparison with women aged ≤ 51 years, the odds ratio (OR) of LBD was 1.5 and 2.2, respectively, in women aged 52-55 and ≥ 56. No association emerged between LBD and parity: in comparison with nulliparae, the OR of LBD were 1.1 and 1.0, respectively, in women reported 1 or 2 or more full term pregnancies. Smokers were at increased risk of LBD, the corresponding OR being for smokers, in comparison with non smokers, 1.2 (95{\%} confidence interval, CI, 1.1-1.3). In comparison with women in the lower tertile of body mass index, the OR of LBD decreased in subsequent tertiles, being, respectively, 0.9 and 0.7 in the middle and highest tertile. The OR of LBD was 2.2 in postmenopausal women, in comparison with premenopausal ones and the OR decreased increasing age at menopause. Ever OC users were at slightly decreased risk of LBD: in comparison with never OC users, the OR was 0.9 (95{\%} CI 0.8-1.0) in ever OC users. Conclusion: The results of this large study confirm, in a Souther European population, the association of age at menopause and body mass on the risk of LBD, and suggest that ever OC women are at decreased risk of LBD.",
keywords = "Low bone density (LBD), Postmenopausal, Risk factors",
author = "{De Aloysio}, D. and {Di Donato}, P. and Giulini, {N. A.} and Bacchi Modena and G. Cicchetti and G. Comitini and G. Gentile and P. Cristiani and A. Careccia and E. Esposito and C. Gigli and G. Mandruzzato and F. Petraglia and F. Bertelli and {Del Frate}, G. and S. Garofalo and L. Marino and Costa, {M. R.} and S. Quaranta and Bossi, {C. M.} and P. Amantea and U. Omodei and M. Vaccari and M. Luerti and F. Repetti and G. Zandonini and F. Raspagliesi and F. Dolci and V. Zacchi and S. Bennici and G. Polizzotti and S. Bottino and F. Raffaelli and C. Minervini and D. Colombo and C. Belloni and A. Viani and G. Cecchini and S. Winkler and Samaja, {B. A.} and E. Pasinetti and M. Penotti and C. Malanetto and M. Massobrio and C. Campagnoli and G. Dolfin and P. Tartaglino and D. Mossotto and P. Pesando and L. Pacilli and Rattazzi, {P. D.} and E. Arisi and M. Gamper and D. Salvatores and E. Bocchin and G. Stellin and G. Meli and V. Azzini and F. Tirozzi and G. Buoso and R. Fraioli and V. Marsoni and C. Cetera and R. Sposetti and U. Bellati and C. Angeloni and M. Buonerba and S. Garzarelli and C. Santilli and M. Mucci and {Di Nisio}, Q. and L. Falasca and D. Ferrante and E. Cirese and Todaro, {P. A.} and C. Romanini and L. Spagnuolo and A. Lanzone and C. Donadio and M. Fabiani and E. Baldaccini and S. Votano and Serra, {G. B.} and P. Bellardini and L. Massacesi and G. Donini and Genazzani, {R. A.} and G. Scarselli and P. Curiel and {De Leo}, V. and A. Melani and {Levi D'Ancona}, V. and G. Giarr{\`e} and {Di Gioia}, E. and P. Ciccarelli and {Donati Sarti}, C. and G. Balsotti and P. Pupita and F. Parazzini",
year = "2002",
month = "6",
day = "25",
doi = "10.1016/S0378-5122(02)00034-8",
language = "English",
volume = "42",
pages = "105--111",
journal = "Maturitas",
issn = "0378-5122",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Risk of low bone density in women attending menopause clinics in Italy

AU - De Aloysio, D.

AU - Di Donato, P.

AU - Giulini, N. A.

AU - Modena, Bacchi

AU - Cicchetti, G.

AU - Comitini, G.

AU - Gentile, G.

AU - Cristiani, P.

AU - Careccia, A.

AU - Esposito, E.

AU - Gigli, C.

AU - Mandruzzato, G.

AU - Petraglia, F.

AU - Bertelli, F.

AU - Del Frate, G.

AU - Garofalo, S.

AU - Marino, L.

AU - Costa, M. R.

AU - Quaranta, S.

AU - Bossi, C. M.

AU - Amantea, P.

AU - Omodei, U.

AU - Vaccari, M.

AU - Luerti, M.

AU - Repetti, F.

AU - Zandonini, G.

AU - Raspagliesi, F.

AU - Dolci, F.

AU - Zacchi, V.

AU - Bennici, S.

AU - Polizzotti, G.

AU - Bottino, S.

AU - Raffaelli, F.

AU - Minervini, C.

AU - Colombo, D.

AU - Belloni, C.

AU - Viani, A.

AU - Cecchini, G.

AU - Winkler, S.

AU - Samaja, B. A.

AU - Pasinetti, E.

AU - Penotti, M.

AU - Malanetto, C.

AU - Massobrio, M.

AU - Campagnoli, C.

AU - Dolfin, G.

AU - Tartaglino, P.

AU - Mossotto, D.

AU - Pesando, P.

AU - Pacilli, L.

AU - Rattazzi, P. D.

AU - Arisi, E.

AU - Gamper, M.

AU - Salvatores, D.

AU - Bocchin, E.

AU - Stellin, G.

AU - Meli, G.

AU - Azzini, V.

AU - Tirozzi, F.

AU - Buoso, G.

AU - Fraioli, R.

AU - Marsoni, V.

AU - Cetera, C.

AU - Sposetti, R.

AU - Bellati, U.

AU - Angeloni, C.

AU - Buonerba, M.

AU - Garzarelli, S.

AU - Santilli, C.

AU - Mucci, M.

AU - Di Nisio, Q.

AU - Falasca, L.

AU - Ferrante, D.

AU - Cirese, E.

AU - Todaro, P. A.

AU - Romanini, C.

AU - Spagnuolo, L.

AU - Lanzone, A.

AU - Donadio, C.

AU - Fabiani, M.

AU - Baldaccini, E.

AU - Votano, S.

AU - Serra, G. B.

AU - Bellardini, P.

AU - Massacesi, L.

AU - Donini, G.

AU - Genazzani, R. A.

AU - Scarselli, G.

AU - Curiel, P.

AU - De Leo, V.

AU - Melani, A.

AU - Levi D'Ancona, V.

AU - Giarrè, G.

AU - Di Gioia, E.

AU - Ciccarelli, P.

AU - Donati Sarti, C.

AU - Balsotti, G.

AU - Pupita, P.

AU - Parazzini, F.

PY - 2002/6/25

Y1 - 2002/6/25

N2 - Objective: In order to offer data on the epidemiological profile of women with low bone density (LBD), we have considered information collected in the framework of a large cross-sectional study conducted on women around menopause attending a network of first level outpatients menopause clinics in Italy. Methods: During 1997 and 2000, a large cross sectional study was conducted on the characteristics of women around menopause attending a network of first level outpatients menopause clinics in Italy for general counseling about menopause or treatment of menopausal symptoms. Eligible for the study were women consecutively observed during the study period. Up to March 2000 a total of 42 464 women (mean age 53 years) were observed at the 268 participating centers. Bone mass density was measured in 25 113 cases, which are considered in this analysis. LBD (i.e. osteopenia or osteoporosis) was defined according to WHO classification. Results: The frequency of LBD increased with age: in comparison with women aged ≤ 51 years, the odds ratio (OR) of LBD was 1.5 and 2.2, respectively, in women aged 52-55 and ≥ 56. No association emerged between LBD and parity: in comparison with nulliparae, the OR of LBD were 1.1 and 1.0, respectively, in women reported 1 or 2 or more full term pregnancies. Smokers were at increased risk of LBD, the corresponding OR being for smokers, in comparison with non smokers, 1.2 (95% confidence interval, CI, 1.1-1.3). In comparison with women in the lower tertile of body mass index, the OR of LBD decreased in subsequent tertiles, being, respectively, 0.9 and 0.7 in the middle and highest tertile. The OR of LBD was 2.2 in postmenopausal women, in comparison with premenopausal ones and the OR decreased increasing age at menopause. Ever OC users were at slightly decreased risk of LBD: in comparison with never OC users, the OR was 0.9 (95% CI 0.8-1.0) in ever OC users. Conclusion: The results of this large study confirm, in a Souther European population, the association of age at menopause and body mass on the risk of LBD, and suggest that ever OC women are at decreased risk of LBD.

AB - Objective: In order to offer data on the epidemiological profile of women with low bone density (LBD), we have considered information collected in the framework of a large cross-sectional study conducted on women around menopause attending a network of first level outpatients menopause clinics in Italy. Methods: During 1997 and 2000, a large cross sectional study was conducted on the characteristics of women around menopause attending a network of first level outpatients menopause clinics in Italy for general counseling about menopause or treatment of menopausal symptoms. Eligible for the study were women consecutively observed during the study period. Up to March 2000 a total of 42 464 women (mean age 53 years) were observed at the 268 participating centers. Bone mass density was measured in 25 113 cases, which are considered in this analysis. LBD (i.e. osteopenia or osteoporosis) was defined according to WHO classification. Results: The frequency of LBD increased with age: in comparison with women aged ≤ 51 years, the odds ratio (OR) of LBD was 1.5 and 2.2, respectively, in women aged 52-55 and ≥ 56. No association emerged between LBD and parity: in comparison with nulliparae, the OR of LBD were 1.1 and 1.0, respectively, in women reported 1 or 2 or more full term pregnancies. Smokers were at increased risk of LBD, the corresponding OR being for smokers, in comparison with non smokers, 1.2 (95% confidence interval, CI, 1.1-1.3). In comparison with women in the lower tertile of body mass index, the OR of LBD decreased in subsequent tertiles, being, respectively, 0.9 and 0.7 in the middle and highest tertile. The OR of LBD was 2.2 in postmenopausal women, in comparison with premenopausal ones and the OR decreased increasing age at menopause. Ever OC users were at slightly decreased risk of LBD: in comparison with never OC users, the OR was 0.9 (95% CI 0.8-1.0) in ever OC users. Conclusion: The results of this large study confirm, in a Souther European population, the association of age at menopause and body mass on the risk of LBD, and suggest that ever OC women are at decreased risk of LBD.

KW - Low bone density (LBD)

KW - Postmenopausal

KW - Risk factors

UR - http://www.scopus.com/inward/record.url?scp=18444391184&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18444391184&partnerID=8YFLogxK

U2 - 10.1016/S0378-5122(02)00034-8

DO - 10.1016/S0378-5122(02)00034-8

M3 - Article

C2 - 12065169

AN - SCOPUS:18444391184

VL - 42

SP - 105

EP - 111

JO - Maturitas

JF - Maturitas

SN - 0378-5122

IS - 2

ER -