Risk of malignant arrhythmias in initially symptomatic patients with wolff-parkinson-white syndrome: Results of a prospective long-term electrophysiological follow-up study

Carlo Pappone, Gabriele Vicedomini, Francesco Manguso, Mario Baldi, Alessia Pappone, Andrea Petretta, Raffaele Vitale, Massimo Saviano, Cristiano Ciaccio, Luigi Giannelli, Zarko Calovic, Luigi Tavazzi, Vincenzo Santinelli

Research output: Contribution to journalArticlepeer-review

Abstract

background-The available amount of detailed long-term data in patients with Wolff-Parkinson-White syndrome is limited, and no prospective electrophysiological studies looking at predictors of malignant arrhythmia are available. Methods and Results-Among 8575 symptomatic Wolff-Parkinson-White patients with atrioventricular reentrant tachycardia referred for electrophysiological test, 369 (mean age, 23±12.5 years) declined catheter ablation and were followed up. The primary end point of the study was to evaluate over a 5-year follow-up the predictors and characteristics of patients who develop malignant arrhythmias. After a mean follow-up of 42.1±10 months, malignant arrhythmias developed in 29 patients (mean age, 13.9±5.6 years; 26 male), resulting in presyncope/syncope (25 patients), hemodynamic collapse (3 patients), or cardiac arrest caused by ventricular fibrillation (1 patient). Of the remaining 340 patients, 168 (mean age, 34.2±9.0 years) remained asymptomatic up to 5 years, and 172 (mean age, 13.6±5.1 years) had benign recurrence, including sustained atrioventricular reentrant tachycardia (132 patients) or atrial fibrillation (40 patients). Compared with the group with no malignant arrhythmias, the group with malignant arrhythmias showed shorter accessory-pathway effective refractory period (P

Original languageEnglish
Pages (from-to)661-668
Number of pages8
JournalCirculation
Volume125
Issue number5
DOIs
Publication statusPublished - Feb 7 2012

Keywords

  • death, sudden
  • risk factors
  • ventricular fibrillation
  • Wolff-Parkinson-White syndrome

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

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