TY - JOUR
T1 - Risk of malignant arrhythmias in initially symptomatic patients with wolff-parkinson-white syndrome
T2 - Results of a prospective long-term electrophysiological follow-up study
AU - Pappone, Carlo
AU - Vicedomini, Gabriele
AU - Manguso, Francesco
AU - Baldi, Mario
AU - Pappone, Alessia
AU - Petretta, Andrea
AU - Vitale, Raffaele
AU - Saviano, Massimo
AU - Ciaccio, Cristiano
AU - Giannelli, Luigi
AU - Calovic, Zarko
AU - Tavazzi, Luigi
AU - Santinelli, Vincenzo
PY - 2012/2/7
Y1 - 2012/2/7
N2 - background-The available amount of detailed long-term data in patients with Wolff-Parkinson-White syndrome is limited, and no prospective electrophysiological studies looking at predictors of malignant arrhythmia are available. Methods and Results-Among 8575 symptomatic Wolff-Parkinson-White patients with atrioventricular reentrant tachycardia referred for electrophysiological test, 369 (mean age, 23±12.5 years) declined catheter ablation and were followed up. The primary end point of the study was to evaluate over a 5-year follow-up the predictors and characteristics of patients who develop malignant arrhythmias. After a mean follow-up of 42.1±10 months, malignant arrhythmias developed in 29 patients (mean age, 13.9±5.6 years; 26 male), resulting in presyncope/syncope (25 patients), hemodynamic collapse (3 patients), or cardiac arrest caused by ventricular fibrillation (1 patient). Of the remaining 340 patients, 168 (mean age, 34.2±9.0 years) remained asymptomatic up to 5 years, and 172 (mean age, 13.6±5.1 years) had benign recurrence, including sustained atrioventricular reentrant tachycardia (132 patients) or atrial fibrillation (40 patients). Compared with the group with no malignant arrhythmias, the group with malignant arrhythmias showed shorter accessory-pathway effective refractory period (P
AB - background-The available amount of detailed long-term data in patients with Wolff-Parkinson-White syndrome is limited, and no prospective electrophysiological studies looking at predictors of malignant arrhythmia are available. Methods and Results-Among 8575 symptomatic Wolff-Parkinson-White patients with atrioventricular reentrant tachycardia referred for electrophysiological test, 369 (mean age, 23±12.5 years) declined catheter ablation and were followed up. The primary end point of the study was to evaluate over a 5-year follow-up the predictors and characteristics of patients who develop malignant arrhythmias. After a mean follow-up of 42.1±10 months, malignant arrhythmias developed in 29 patients (mean age, 13.9±5.6 years; 26 male), resulting in presyncope/syncope (25 patients), hemodynamic collapse (3 patients), or cardiac arrest caused by ventricular fibrillation (1 patient). Of the remaining 340 patients, 168 (mean age, 34.2±9.0 years) remained asymptomatic up to 5 years, and 172 (mean age, 13.6±5.1 years) had benign recurrence, including sustained atrioventricular reentrant tachycardia (132 patients) or atrial fibrillation (40 patients). Compared with the group with no malignant arrhythmias, the group with malignant arrhythmias showed shorter accessory-pathway effective refractory period (P
KW - death, sudden
KW - risk factors
KW - ventricular fibrillation
KW - Wolff-Parkinson-White syndrome
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U2 - 10.1161/CIRCULATIONAHA.111.065722
DO - 10.1161/CIRCULATIONAHA.111.065722
M3 - Article
C2 - 22215859
AN - SCOPUS:84856899997
VL - 125
SP - 661
EP - 668
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 5
ER -