Risk of malignant pleural mesothelioma and polymorphisms in genes involved in the genome stability and xenobiotics metabolism

Federica Gemignani, Monica Neri, Fabio Bottari, Roberto Barale, Pier Aldo Canessa, Federico Canzian, Marcello Ceppi, Irene Spitaleri, Monica Cipollini, Gian Paolo Ivaldi, Manlio Mencoboni, Paola Scaruffi, Gian Paolo Tonini, Donatella Ugolini, Luciano Mutti, Stefano Bonassi, Stefano Landi

Research output: Contribution to journalArticle

Abstract

Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer mostly attributable to asbestos exposure. Many polymorphic genes encoding for xenobiotic and oxidative metabolism enzymes (XME) or involved in genome stability (GS) can modulate individual MPM risk in exposed populations. An association study was carried out in a case-control setting including 119 MPM patients and two groups of referent subjects (104 with and 695 without documented asbestos exposure). Forty-eight polymorphisms in XME genes and 75 in GS-genes were evaluated. Statistical analysis revealed some significant associations of studied polymorphisms with MPM risk, but most of them disappeared after applying Bonferroni correction (new threshold for statistical significance: p = 4.07 × 10-4). On the other hand, the nucleotidic change 282C > T within NAT2 held the statistical significance (OR = 3.54; 95% CI 1.75-7.16; p = 0.0002), reinforcing existing evidences that describe genetic polymorphisms of NAT2 possibly involved in the etiology of the MPM.

Original languageEnglish
Pages (from-to)76-83
Number of pages8
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume671
Issue number1-2
DOIs
Publication statusPublished - Dec 1 2009

Keywords

  • DNA repair
  • Mesothelioma
  • Microarray analysis
  • Molecular epidemiology
  • Oxidative stress
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

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  • Cite this

    Gemignani, F., Neri, M., Bottari, F., Barale, R., Canessa, P. A., Canzian, F., Ceppi, M., Spitaleri, I., Cipollini, M., Ivaldi, G. P., Mencoboni, M., Scaruffi, P., Tonini, G. P., Ugolini, D., Mutti, L., Bonassi, S., & Landi, S. (2009). Risk of malignant pleural mesothelioma and polymorphisms in genes involved in the genome stability and xenobiotics metabolism. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 671(1-2), 76-83. https://doi.org/10.1016/j.mrfmmm.2009.09.003