Risk of nonmelanoma skin cancer in italian organ transplant recipients. A registry-based study

Luigi Naldi, Anna Belloni Fortina, Silvia Lovati, Annalisa Barba, Eliana Gotti, Gianpaolo Tessari, Donatella Schena, Andrea Diociaiuti, Giuseppe Nanni, Ilaria Lesnoni La Parola, Cinzia Masini, Stefano Piaserico, Andrea Peserico, Tullio Cainelli, Giuseppe Remuzzi

Research output: Contribution to journalArticlepeer-review


Background. Organ transplant recipients are at an increased risk of nonmelanoma skin cancer. Few data concern heart transplantation and populations from southern Europe. Methods. A total of 1329 patients who received their first kidney (1062 subjects) or heart allograft (267 subjects) were included in a partly retrospective cohort study to evaluate the risk of skin cancer. The incidence rate per 1000 person-years and the cumulative incidence were computed. Standardized morbidity ratio was estimated by comparison with Italian cancer registry data. To analyze the role of potential prognostic factors, Cox's regression method was used. Results. The overall incidence rate of nonmelanoma skin cancer was 10.0 cases per 1000 posttransplant person-years (95% confidence interval 8.2-11.7). This estimate was far higher than expected in the general population. The overall risk of developing skin cancer increased from a cumulative incidence of 5.8% after 5 posttransplant years to an incidence of 10.8% after 10 years of graft survival. In a Cox proportional hazard risk model, the most important factors that appeared to favor the development of skin cancer were age at transplantation and sex. After adjustment for age at transplantation and sex, no definite increased risk was documented among heart as compared with kindney transplant recipients. Conclusions. Our study confirms the increased risk of nonmelanoma skin cancer among organ transplant recipients in a southern European population.

Original languageEnglish
Pages (from-to)1479-1484
Number of pages6
Issue number10
Publication statusPublished - Nov 27 2000

ASJC Scopus subject areas

  • Transplantation
  • Immunology


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