Risk of Surgery for Congenital Heart Disease in the Adult: A Multicentered European Study

Vladimiro L. Vida, Hakan Berggren, William J. Brawn, Willem Daenen, Duccio Di Carlo, Roberto Di Donato, Harald L. Lindberg, Antonio F. Corno, Jose Fragata, Martin J. Elliott, Viktor Hraska, Lazlo Kiraly, François Lacour-Gayet, Bohdan Maruszewski, Jean Rubay, Heikki Sairanen, George Sarris, Andreas Urban, Carin Van Doorn, Gerhard ZiemerGiovanni Stellin

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Background: Surgery for congenital heart disease (CHD) has changed considerably during the last three decades. The results of primary repair have steadily improved, to allow treating almost all patients within the pediatric age; nonetheless an increasing population of adult patients requires surgical treatment. The objective of this study is to present the early surgical results of patients who require surgery for CHD in the adult population within a multicentered European study population. Methods: Data relative to the hospital course of 2,012 adult patients (age ≥18 years) who required surgical treatment for CHD from January 1, 1997 through December 31, 2004 were reviewed. Nineteen cardiothoracic centers from 13 European countries contributed to the data collection. Results: Mean age at surgery was 34.4 ± 14.53 years. Most of the operations were corrective procedures (1,509 patients, 75%), followed by reoperations (464 patients, 23.1%) and palliative procedures (39 patients, 1.9%). Six hundred forty-nine patients (32.2%) required surgical closure of an isolated ostium secundum atrial septal defect. Overall hospital mortality was 2%. Preoperative cyanosis, arrhythmias, and NYHA class III-IV, proved significant risk factors for hospital mortality. Follow-up data were available in 1,342 of 1,972 patients (68%) who were discharged home. Late deaths occurred in 6 patients (0.5%). Overall survival probability was 97% at 60 months, which is higher for corrective procedures (98.2%) if compared with reoperations (94.1%) and palliations (86.1%). Conclusions: Surgical treatment of CHD in adult patients, in specialized cardiac units, proved quite safe, beneficial, and low-risk.

Original languageEnglish
Pages (from-to)161-168
Number of pages8
JournalAnnals of Thoracic Surgery
Volume83
Issue number1
DOIs
Publication statusPublished - Jan 2007

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Heart Diseases
Hospital Mortality
Reoperation
Population
Cyanosis
Atrial Heart Septal Defects
Cardiac Arrhythmias
Therapeutics
Pediatrics
Survival

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Risk of Surgery for Congenital Heart Disease in the Adult : A Multicentered European Study. / Vida, Vladimiro L.; Berggren, Hakan; Brawn, William J.; Daenen, Willem; Di Carlo, Duccio; Di Donato, Roberto; Lindberg, Harald L.; Corno, Antonio F.; Fragata, Jose; Elliott, Martin J.; Hraska, Viktor; Kiraly, Lazlo; Lacour-Gayet, François; Maruszewski, Bohdan; Rubay, Jean; Sairanen, Heikki; Sarris, George; Urban, Andreas; Van Doorn, Carin; Ziemer, Gerhard; Stellin, Giovanni.

In: Annals of Thoracic Surgery, Vol. 83, No. 1, 01.2007, p. 161-168.

Research output: Contribution to journalArticle

Vida, VL, Berggren, H, Brawn, WJ, Daenen, W, Di Carlo, D, Di Donato, R, Lindberg, HL, Corno, AF, Fragata, J, Elliott, MJ, Hraska, V, Kiraly, L, Lacour-Gayet, F, Maruszewski, B, Rubay, J, Sairanen, H, Sarris, G, Urban, A, Van Doorn, C, Ziemer, G & Stellin, G 2007, 'Risk of Surgery for Congenital Heart Disease in the Adult: A Multicentered European Study', Annals of Thoracic Surgery, vol. 83, no. 1, pp. 161-168. https://doi.org/10.1016/j.athoracsur.2006.07.045
Vida, Vladimiro L. ; Berggren, Hakan ; Brawn, William J. ; Daenen, Willem ; Di Carlo, Duccio ; Di Donato, Roberto ; Lindberg, Harald L. ; Corno, Antonio F. ; Fragata, Jose ; Elliott, Martin J. ; Hraska, Viktor ; Kiraly, Lazlo ; Lacour-Gayet, François ; Maruszewski, Bohdan ; Rubay, Jean ; Sairanen, Heikki ; Sarris, George ; Urban, Andreas ; Van Doorn, Carin ; Ziemer, Gerhard ; Stellin, Giovanni. / Risk of Surgery for Congenital Heart Disease in the Adult : A Multicentered European Study. In: Annals of Thoracic Surgery. 2007 ; Vol. 83, No. 1. pp. 161-168.
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abstract = "Background: Surgery for congenital heart disease (CHD) has changed considerably during the last three decades. The results of primary repair have steadily improved, to allow treating almost all patients within the pediatric age; nonetheless an increasing population of adult patients requires surgical treatment. The objective of this study is to present the early surgical results of patients who require surgery for CHD in the adult population within a multicentered European study population. Methods: Data relative to the hospital course of 2,012 adult patients (age ≥18 years) who required surgical treatment for CHD from January 1, 1997 through December 31, 2004 were reviewed. Nineteen cardiothoracic centers from 13 European countries contributed to the data collection. Results: Mean age at surgery was 34.4 ± 14.53 years. Most of the operations were corrective procedures (1,509 patients, 75{\%}), followed by reoperations (464 patients, 23.1{\%}) and palliative procedures (39 patients, 1.9{\%}). Six hundred forty-nine patients (32.2{\%}) required surgical closure of an isolated ostium secundum atrial septal defect. Overall hospital mortality was 2{\%}. Preoperative cyanosis, arrhythmias, and NYHA class III-IV, proved significant risk factors for hospital mortality. Follow-up data were available in 1,342 of 1,972 patients (68{\%}) who were discharged home. Late deaths occurred in 6 patients (0.5{\%}). Overall survival probability was 97{\%} at 60 months, which is higher for corrective procedures (98.2{\%}) if compared with reoperations (94.1{\%}) and palliations (86.1{\%}). Conclusions: Surgical treatment of CHD in adult patients, in specialized cardiac units, proved quite safe, beneficial, and low-risk.",
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AU - Vida, Vladimiro L.

AU - Berggren, Hakan

AU - Brawn, William J.

AU - Daenen, Willem

AU - Di Carlo, Duccio

AU - Di Donato, Roberto

AU - Lindberg, Harald L.

AU - Corno, Antonio F.

AU - Fragata, Jose

AU - Elliott, Martin J.

AU - Hraska, Viktor

AU - Kiraly, Lazlo

AU - Lacour-Gayet, François

AU - Maruszewski, Bohdan

AU - Rubay, Jean

AU - Sairanen, Heikki

AU - Sarris, George

AU - Urban, Andreas

AU - Van Doorn, Carin

AU - Ziemer, Gerhard

AU - Stellin, Giovanni

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N2 - Background: Surgery for congenital heart disease (CHD) has changed considerably during the last three decades. The results of primary repair have steadily improved, to allow treating almost all patients within the pediatric age; nonetheless an increasing population of adult patients requires surgical treatment. The objective of this study is to present the early surgical results of patients who require surgery for CHD in the adult population within a multicentered European study population. Methods: Data relative to the hospital course of 2,012 adult patients (age ≥18 years) who required surgical treatment for CHD from January 1, 1997 through December 31, 2004 were reviewed. Nineteen cardiothoracic centers from 13 European countries contributed to the data collection. Results: Mean age at surgery was 34.4 ± 14.53 years. Most of the operations were corrective procedures (1,509 patients, 75%), followed by reoperations (464 patients, 23.1%) and palliative procedures (39 patients, 1.9%). Six hundred forty-nine patients (32.2%) required surgical closure of an isolated ostium secundum atrial septal defect. Overall hospital mortality was 2%. Preoperative cyanosis, arrhythmias, and NYHA class III-IV, proved significant risk factors for hospital mortality. Follow-up data were available in 1,342 of 1,972 patients (68%) who were discharged home. Late deaths occurred in 6 patients (0.5%). Overall survival probability was 97% at 60 months, which is higher for corrective procedures (98.2%) if compared with reoperations (94.1%) and palliations (86.1%). Conclusions: Surgical treatment of CHD in adult patients, in specialized cardiac units, proved quite safe, beneficial, and low-risk.

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