Risk of transmission of hepatitis B virus from anti-HBc positive cadaveric organ donors

A collaborative study

T. M. De Feo, F. Poli, F. Mozzi, M. P. Moretti, M. Scalamogna

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Organ donors with a serologic profile of recovered (HBsAg negative and/or anti-HBc IgG positive) hepatitis B virus infection (HBV) have been reported to transmit HBV to recipients. In Italy, up until 2002, anti-HBc determination was not mandatory. We retrospectively evaluated the incidence of HBV transmission among recipients transplanted with organs from anti-HBc positive donors from 1997 to 1999. Anti-HBc was screened in 886 available sera among 964 HBsAg and anti-HCV negative donors. HBV transmission was evaluated in 325 kidney, liver, and heart recipients according to their pretransplant HBV serum profile. Of 210 anti-HBc positive donors, 185 were anti-HBc positive/anti-HBs positive and 25 anti-HBc positive/anti-HBs negative with a prevalence of 20.8% and 2.8%, respectively. One hundred seven sera (51%) were collected from donors after transfusion of blood components, the remainder were either before transfusion or from nontransfused donors. The 210 anti-HBc positive subjects donated 356 kidneys, 117 livers and 117 hearts, among whom follow-up is presently available for 251 kidney, 61 liver, and 25 heart recipients. No HBV transmission was observed independent of the recipient immunological profile among the kidney or heart recipients. In liver recipients, no transmission was reported in recovered or vaccinated patients, while a high incidence (43%) of de novo hepatitis was observed among naive patients. In conclusion, there does not seem to be a risk of transmitting HBV through anti-HBc positive transplants in heart and kidney recipients; only naïve liver recipients are at high risk of HBV infection.

Original languageEnglish
Pages (from-to)1238-1239
Number of pages2
JournalTransplantation Proceedings
Volume37
Issue number2
DOIs
Publication statusPublished - Mar 2005

Fingerprint

Virus Diseases
Hepatitis B virus
Tissue Donors
Infectious Disease Transmission
Kidney
Liver
Hepatitis B Surface Antigens
Blood Component Transfusion
Serum
Incidence
Italy
Hepatitis
Transplants
Infection

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Risk of transmission of hepatitis B virus from anti-HBc positive cadaveric organ donors : A collaborative study. / De Feo, T. M.; Poli, F.; Mozzi, F.; Moretti, M. P.; Scalamogna, M.

In: Transplantation Proceedings, Vol. 37, No. 2, 03.2005, p. 1238-1239.

Research output: Contribution to journalArticle

De Feo, T. M. ; Poli, F. ; Mozzi, F. ; Moretti, M. P. ; Scalamogna, M. / Risk of transmission of hepatitis B virus from anti-HBc positive cadaveric organ donors : A collaborative study. In: Transplantation Proceedings. 2005 ; Vol. 37, No. 2. pp. 1238-1239.
@article{84ee7721e5ff48daa05a03591ed5c2a2,
title = "Risk of transmission of hepatitis B virus from anti-HBc positive cadaveric organ donors: A collaborative study",
abstract = "Organ donors with a serologic profile of recovered (HBsAg negative and/or anti-HBc IgG positive) hepatitis B virus infection (HBV) have been reported to transmit HBV to recipients. In Italy, up until 2002, anti-HBc determination was not mandatory. We retrospectively evaluated the incidence of HBV transmission among recipients transplanted with organs from anti-HBc positive donors from 1997 to 1999. Anti-HBc was screened in 886 available sera among 964 HBsAg and anti-HCV negative donors. HBV transmission was evaluated in 325 kidney, liver, and heart recipients according to their pretransplant HBV serum profile. Of 210 anti-HBc positive donors, 185 were anti-HBc positive/anti-HBs positive and 25 anti-HBc positive/anti-HBs negative with a prevalence of 20.8{\%} and 2.8{\%}, respectively. One hundred seven sera (51{\%}) were collected from donors after transfusion of blood components, the remainder were either before transfusion or from nontransfused donors. The 210 anti-HBc positive subjects donated 356 kidneys, 117 livers and 117 hearts, among whom follow-up is presently available for 251 kidney, 61 liver, and 25 heart recipients. No HBV transmission was observed independent of the recipient immunological profile among the kidney or heart recipients. In liver recipients, no transmission was reported in recovered or vaccinated patients, while a high incidence (43{\%}) of de novo hepatitis was observed among naive patients. In conclusion, there does not seem to be a risk of transmitting HBV through anti-HBc positive transplants in heart and kidney recipients; only na{\"i}ve liver recipients are at high risk of HBV infection.",
author = "{De Feo}, {T. M.} and F. Poli and F. Mozzi and Moretti, {M. P.} and M. Scalamogna",
year = "2005",
month = "3",
doi = "10.1016/j.transproceed.2004.12.041",
language = "English",
volume = "37",
pages = "1238--1239",
journal = "Transplantation Proceedings",
issn = "0041-1345",
publisher = "Elsevier USA",
number = "2",

}

TY - JOUR

T1 - Risk of transmission of hepatitis B virus from anti-HBc positive cadaveric organ donors

T2 - A collaborative study

AU - De Feo, T. M.

AU - Poli, F.

AU - Mozzi, F.

AU - Moretti, M. P.

AU - Scalamogna, M.

PY - 2005/3

Y1 - 2005/3

N2 - Organ donors with a serologic profile of recovered (HBsAg negative and/or anti-HBc IgG positive) hepatitis B virus infection (HBV) have been reported to transmit HBV to recipients. In Italy, up until 2002, anti-HBc determination was not mandatory. We retrospectively evaluated the incidence of HBV transmission among recipients transplanted with organs from anti-HBc positive donors from 1997 to 1999. Anti-HBc was screened in 886 available sera among 964 HBsAg and anti-HCV negative donors. HBV transmission was evaluated in 325 kidney, liver, and heart recipients according to their pretransplant HBV serum profile. Of 210 anti-HBc positive donors, 185 were anti-HBc positive/anti-HBs positive and 25 anti-HBc positive/anti-HBs negative with a prevalence of 20.8% and 2.8%, respectively. One hundred seven sera (51%) were collected from donors after transfusion of blood components, the remainder were either before transfusion or from nontransfused donors. The 210 anti-HBc positive subjects donated 356 kidneys, 117 livers and 117 hearts, among whom follow-up is presently available for 251 kidney, 61 liver, and 25 heart recipients. No HBV transmission was observed independent of the recipient immunological profile among the kidney or heart recipients. In liver recipients, no transmission was reported in recovered or vaccinated patients, while a high incidence (43%) of de novo hepatitis was observed among naive patients. In conclusion, there does not seem to be a risk of transmitting HBV through anti-HBc positive transplants in heart and kidney recipients; only naïve liver recipients are at high risk of HBV infection.

AB - Organ donors with a serologic profile of recovered (HBsAg negative and/or anti-HBc IgG positive) hepatitis B virus infection (HBV) have been reported to transmit HBV to recipients. In Italy, up until 2002, anti-HBc determination was not mandatory. We retrospectively evaluated the incidence of HBV transmission among recipients transplanted with organs from anti-HBc positive donors from 1997 to 1999. Anti-HBc was screened in 886 available sera among 964 HBsAg and anti-HCV negative donors. HBV transmission was evaluated in 325 kidney, liver, and heart recipients according to their pretransplant HBV serum profile. Of 210 anti-HBc positive donors, 185 were anti-HBc positive/anti-HBs positive and 25 anti-HBc positive/anti-HBs negative with a prevalence of 20.8% and 2.8%, respectively. One hundred seven sera (51%) were collected from donors after transfusion of blood components, the remainder were either before transfusion or from nontransfused donors. The 210 anti-HBc positive subjects donated 356 kidneys, 117 livers and 117 hearts, among whom follow-up is presently available for 251 kidney, 61 liver, and 25 heart recipients. No HBV transmission was observed independent of the recipient immunological profile among the kidney or heart recipients. In liver recipients, no transmission was reported in recovered or vaccinated patients, while a high incidence (43%) of de novo hepatitis was observed among naive patients. In conclusion, there does not seem to be a risk of transmitting HBV through anti-HBc positive transplants in heart and kidney recipients; only naïve liver recipients are at high risk of HBV infection.

UR - http://www.scopus.com/inward/record.url?scp=17844400580&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17844400580&partnerID=8YFLogxK

U2 - 10.1016/j.transproceed.2004.12.041

DO - 10.1016/j.transproceed.2004.12.041

M3 - Article

VL - 37

SP - 1238

EP - 1239

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

IS - 2

ER -