Risk of tumour seeding after percutaneous radiofrequency ablation for hepatocellular carcinoma

T. Livraghi, S. Lazzaroni, F. Meloni, L. Solbiati

Research output: Contribution to journalArticlepeer-review

Abstract

Background: A recent small study reported a high rate of neoplastic seeding after cooled-tip radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) in patients who had undergone previous needle biopsy. Tumour seeding was associated with subcapsular tumour location, poorly differentiated tumours and a high α-fetoprotein (AFP) level. The aim of the present study was to determine the rate of neoplastic seeding after RFA in a large series of unselected patients with HCC who had a long follow-up. Methods: A total of 1314 patients with 2542 nodules were treated in three centres. Median follow-up was 37 months. Needle biopsy had been performed before RFA in 241 patients (18.3 per cent). The influence of subcapsular location, high AFP level and previous biopsy on risk of tumour seeding was assessed. Results: Neoplastic seeding was identified in 12 patients (0.9 per cent); the rate was comparable at the three centres (0.9, 0.7 and 1.4 per cent). Only previous biopsy was significantly associated with tumour seeding (P = 0.004). Conclusion: RFA with a cooled-tip needle was associated with a low risk of neoplastic seeding, even in unselected patients. The use of biopsy before RFA is to be discouraged, particularly when liver transplantation is a possibility at a later date.

Original languageEnglish
Pages (from-to)856-858
Number of pages3
JournalBritish Journal of Surgery
Volume92
Issue number7
DOIs
Publication statusPublished - Jul 2005

ASJC Scopus subject areas

  • Surgery

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