Risk of type 1 diabetes development in children with incidental hyperglycemic: A multicenter Italian study

Renata Lorini, A. Alibrandi, L. Vitali, C. Klersy, M. Martinetti, C. Betterle, G. D'Annunzio, E. Bonifacio

Research output: Contribution to journalArticle

Abstract

OBJECTIVE - The aim of our study was to determine whether children with incidental hyperglycemia are at an increased risk of developing type 1 diabetes. RESEARCH DESIGN AND METHODS - A total of 748 subjects, 1-18 years of age (9.04 ± 3.62, mean ± SD), without family history of type 1 diabetes, without obesity, and not receiving drugs were studied and found to have incidental elevated glycemia defined as fasting plasma glucose >5.6 mmol/l confirmed on two occasions. Subjects were tested for immunological, metabolic, and immunogenetic markers. RESULTS - Islet cell antibodies >5 Juvenile Diabetes Foundation units were found in 10% of subjects, elevated insulin autoantibody levels in 4.6%, GAD antibody in 4.9%, and antityrosine phosphatase-like protein autoantibodies in 3.9%. First-phase insulin response (FPIR) was

Original languageEnglish
Pages (from-to)1210-1216
Number of pages7
JournalDiabetes Care
Volume24
Issue number7
Publication statusPublished - 2001

Fingerprint

Child Development
Type 1 Diabetes Mellitus
Autoantibodies
Multicenter Studies
Insulin
Immunogenetics
Phosphoprotein Phosphatases
Hyperglycemia
Fasting
Research Design
Obesity
Glucose
Antibodies
Pharmaceutical Preparations
islet cell antibody

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Lorini, R., Alibrandi, A., Vitali, L., Klersy, C., Martinetti, M., Betterle, C., ... Bonifacio, E. (2001). Risk of type 1 diabetes development in children with incidental hyperglycemic: A multicenter Italian study. Diabetes Care, 24(7), 1210-1216.

Risk of type 1 diabetes development in children with incidental hyperglycemic : A multicenter Italian study. / Lorini, Renata; Alibrandi, A.; Vitali, L.; Klersy, C.; Martinetti, M.; Betterle, C.; D'Annunzio, G.; Bonifacio, E.

In: Diabetes Care, Vol. 24, No. 7, 2001, p. 1210-1216.

Research output: Contribution to journalArticle

Lorini, R, Alibrandi, A, Vitali, L, Klersy, C, Martinetti, M, Betterle, C, D'Annunzio, G & Bonifacio, E 2001, 'Risk of type 1 diabetes development in children with incidental hyperglycemic: A multicenter Italian study', Diabetes Care, vol. 24, no. 7, pp. 1210-1216.
Lorini R, Alibrandi A, Vitali L, Klersy C, Martinetti M, Betterle C et al. Risk of type 1 diabetes development in children with incidental hyperglycemic: A multicenter Italian study. Diabetes Care. 2001;24(7):1210-1216.
Lorini, Renata ; Alibrandi, A. ; Vitali, L. ; Klersy, C. ; Martinetti, M. ; Betterle, C. ; D'Annunzio, G. ; Bonifacio, E. / Risk of type 1 diabetes development in children with incidental hyperglycemic : A multicenter Italian study. In: Diabetes Care. 2001 ; Vol. 24, No. 7. pp. 1210-1216.
@article{3edb7e1e52be46a193a0675898b13657,
title = "Risk of type 1 diabetes development in children with incidental hyperglycemic: A multicenter Italian study",
abstract = "OBJECTIVE - The aim of our study was to determine whether children with incidental hyperglycemia are at an increased risk of developing type 1 diabetes. RESEARCH DESIGN AND METHODS - A total of 748 subjects, 1-18 years of age (9.04 ± 3.62, mean ± SD), without family history of type 1 diabetes, without obesity, and not receiving drugs were studied and found to have incidental elevated glycemia defined as fasting plasma glucose >5.6 mmol/l confirmed on two occasions. Subjects were tested for immunological, metabolic, and immunogenetic markers. RESULTS - Islet cell antibodies >5 Juvenile Diabetes Foundation units were found in 10{\%} of subjects, elevated insulin autoantibody levels in 4.6{\%}, GAD antibody in 4.9{\%}, and antityrosine phosphatase-like protein autoantibodies in 3.9{\%}. First-phase insulin response (FPIR) was",
author = "Renata Lorini and A. Alibrandi and L. Vitali and C. Klersy and M. Martinetti and C. Betterle and G. D'Annunzio and E. Bonifacio",
year = "2001",
language = "English",
volume = "24",
pages = "1210--1216",
journal = "Diabetes Care",
issn = "1935-5548",
publisher = "American Diabetes Association Inc.",
number = "7",

}

TY - JOUR

T1 - Risk of type 1 diabetes development in children with incidental hyperglycemic

T2 - A multicenter Italian study

AU - Lorini, Renata

AU - Alibrandi, A.

AU - Vitali, L.

AU - Klersy, C.

AU - Martinetti, M.

AU - Betterle, C.

AU - D'Annunzio, G.

AU - Bonifacio, E.

PY - 2001

Y1 - 2001

N2 - OBJECTIVE - The aim of our study was to determine whether children with incidental hyperglycemia are at an increased risk of developing type 1 diabetes. RESEARCH DESIGN AND METHODS - A total of 748 subjects, 1-18 years of age (9.04 ± 3.62, mean ± SD), without family history of type 1 diabetes, without obesity, and not receiving drugs were studied and found to have incidental elevated glycemia defined as fasting plasma glucose >5.6 mmol/l confirmed on two occasions. Subjects were tested for immunological, metabolic, and immunogenetic markers. RESULTS - Islet cell antibodies >5 Juvenile Diabetes Foundation units were found in 10% of subjects, elevated insulin autoantibody levels in 4.6%, GAD antibody in 4.9%, and antityrosine phosphatase-like protein autoantibodies in 3.9%. First-phase insulin response (FPIR) was

AB - OBJECTIVE - The aim of our study was to determine whether children with incidental hyperglycemia are at an increased risk of developing type 1 diabetes. RESEARCH DESIGN AND METHODS - A total of 748 subjects, 1-18 years of age (9.04 ± 3.62, mean ± SD), without family history of type 1 diabetes, without obesity, and not receiving drugs were studied and found to have incidental elevated glycemia defined as fasting plasma glucose >5.6 mmol/l confirmed on two occasions. Subjects were tested for immunological, metabolic, and immunogenetic markers. RESULTS - Islet cell antibodies >5 Juvenile Diabetes Foundation units were found in 10% of subjects, elevated insulin autoantibody levels in 4.6%, GAD antibody in 4.9%, and antityrosine phosphatase-like protein autoantibodies in 3.9%. First-phase insulin response (FPIR) was

UR - http://www.scopus.com/inward/record.url?scp=0035405823&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035405823&partnerID=8YFLogxK

M3 - Article

C2 - 11423504

AN - SCOPUS:0035405823

VL - 24

SP - 1210

EP - 1216

JO - Diabetes Care

JF - Diabetes Care

SN - 1935-5548

IS - 7

ER -