Risk of type 1 diabetes development in children with incidental hyperglycemic: A multicenter Italian study

Renata Lorini, A. Alibrandi, L. Vitali, C. Klersy, M. Martinetti, C. Betterle, G. D'Annunzio, E. Bonifacio

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE - The aim of our study was to determine whether children with incidental hyperglycemia are at an increased risk of developing type 1 diabetes. RESEARCH DESIGN AND METHODS - A total of 748 subjects, 1-18 years of age (9.04 ± 3.62, mean ± SD), without family history of type 1 diabetes, without obesity, and not receiving drugs were studied and found to have incidental elevated glycemia defined as fasting plasma glucose >5.6 mmol/l confirmed on two occasions. Subjects were tested for immunological, metabolic, and immunogenetic markers. RESULTS - Islet cell antibodies >5 Juvenile Diabetes Foundation units were found in 10% of subjects, elevated insulin autoantibody levels in 4.6%, GAD antibody in 4.9%, and antityrosine phosphatase-like protein autoantibodies in 3.9%. First-phase insulin response (FPIR) was

Original languageEnglish
Pages (from-to)1210-1216
Number of pages7
JournalDiabetes Care
Volume24
Issue number7
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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