Risk of vertebral fractures in hypoparathyroidism

Anna Maria Formenti, Francesco Tecilazich, Raffaele Giubbini, Andrea Giustina

Research output: Contribution to journalReview articlepeer-review


Parathyroid hormone (PTH) exerts both anabolic and catabolic actions on bone,depending on the duration and periodicity of exposure. Hypoparathyroidism is defined by inadequate production of PTH in the presence oflow serum calcium. In hypoparathyroidism it has been reported an increase in corticaland trabecular bone mass, but it is still unknown if these quantitative variations maybe accompanied by qualitative ones and increased bone strength. Despite the extensive data available on the effects of hypoparathyroidism on bone, itseffect on the hard end point in this area which is the risk of fractures still remainsunresolved and highly debated. As a matter of fact no previous review has focused onthis relevant clinical topic. This review will deal with the various aspects of bone metabolism (turn-over,density, quality) in hypoparathyroidism, focusing on the few data available on therisk of fracture and in particular of morphometric vertebral fractures, the emerging way to assess actual skeletal fragility particularly in secondary forms of osteoporosis.

Original languageEnglish
Pages (from-to)295-302
Number of pages8
JournalReviews in Endocrine and Metabolic Disorders
Issue number3
Publication statusPublished - Sep 1 2019


  • Bone metabolism
  • Bone mineral density
  • Bone quality
  • Hypoparathyroidism
  • Morphometry
  • Parathyroid hormone
  • Vertebral fractures

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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