Risk Profile of Symptomatic Lacunar Stroke Versus Nonlobar Intracerebral Hemorrhage

Andrea Morotti, Maurizio Paciaroni, Andrea Zini, Giorgio Silvestrelli, Elisabetta Del Zotto, Valeria Caso, Maria Luisa Dell’Acqua, Anna Maria Simone, Alessia Lanari, Paolo Costa, Loris Poli, Valeria de Giuli, Massimo Gamba, Alfonso Ciccone, Marco Ritelli, Augusto Di Castelnuovo, Licia Iacoviello, Marina Colombi, Giancarlo Agnelli, Mario GrassiGiovanni de Gaetano, Alessandro Padovani, Alessandro Pezzini

Research output: Contribution to journalArticlepeer-review


BACKGROUND AND PURPOSE—: Although lacunar stroke (LS) and deep intracerebral hemorrhage (dICH) represent acute manifestations of the same pathological process involving cerebral small vessels (small vessel disease), it remains unclear what factors predispose to one phenotype rather than the other at individual level. METHODS—: Consecutive patients with either acute symptomatic LS or dICH were prospectively enrolled as part of a multicenter Italian study. We compared the risk factor profile of the 2 subgroups using multivariable logistic regression. RESULTS—: During a time course of 9.5 years, 1931 subjects (1434 LS and 497 dICH; mean age, 71.3±13.3 years; males, 55.5%) qualified for the analysis. Current smoking was associated with LS (odds ratio [OR], 2.17; P

Original languageEnglish
Publication statusAccepted/In press - Jun 21 2016

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing

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