Risk profiles in type 2 diabetes (metabolic syndrome): Integration of IL-10 polymorphisms and laboratory parameters to identify vascular damages related complications

G. I. Forte, G. Pilato, L. Vaccarino, M. Sanacore, G. Candore, G. Colonna Romano, R. Testa, C. Franceschi, M. Capri, M. Marra, A. R. Bonfigli, C. Caruso, L. Scola, D. Lio

Research output: Contribution to journalArticle

Abstract

Recently it has been reported that low serum IL-10 levels are associated with an increased susceptibility for metabolic syndrome and type 2 diabetes mellitus (T2DM). We investigated whether the -1087G/A (rs1800896), -824C/T (rs1800871), -597C/A (rs1800872) IL-10 polymorphisms were associated with type 2 diabetes in a study on a cohort of Italian Caucasians comprising 490 type 2 diabetic and 349 control subjects. Stratifying the data according to IL-10 genotypes, trends for the progressive increase of glucose and neutrophil levels were observed in -1087GG vs. -1087GA vs. -1087AA positive diabetic patients (-1087GG

Original languageEnglish
Pages (from-to)898-903
Number of pages6
JournalCurrent Pharmaceutical Design
Volume16
Issue number7
DOIs
Publication statusPublished - Mar 2010

Keywords

  • Cardiovascular disease
  • Chronic kidney failure
  • Grade of membership
  • IL-10 genotypes
  • Metabolic syndrome
  • Risk profile
  • Type 2 diabetes

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

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