Abstract
Inherited mutations in BRCA1 and BRCA2 increase sigfincantly the risk of developing breast and ovarian cancers, and they have been associated with increased risks of developing other types of cancer. Although screening programs have been implemented in order to detect cancers at the early stage, they resulted ineffective. To date, risk-reducing bilateral salpingo-oophorectomy represents the only procedure allowing reducing the incidence of ovarian cancer and increasing survival among BRCA1 and -2 mutation carriers. In the present review we will discuss the advantages and disadvantages related to the execution of prophylactic surgery, thus underlying possible beneficial and detrimental effects of this kind of surgery in premenopausal women. Additionally, we will investigate further therapeutic strategies aimed to reduce the risk of developing ovarian cancer, without affected patients' hormonal status.
| Original language | English |
|---|---|
| Pages (from-to) | 536-543 |
| Number of pages | 8 |
| Journal | Minerva Ginecologica |
| Volume | 68 |
| Issue number | 5 |
| Publication status | Published - Oct 1 2016 |
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Keywords
- BRCA1 gene
- BRCA2 gene
- Ovarian neoplasms
- Ovariectomy
- Prophylactic surgical procedures
ASJC Scopus subject areas
- Obstetrics and Gynaecology
Cite this
Risk-reducing surgery on the uterine adnexa : Timing and type of surgical treatment, and pathology report. / Signorelli, Mauro; Bogani, Giorgio; Ditto, Antonino; Martinelli, Fabio; Chiappa, Valentina; Lopez, Carlos; Scaffa, Cono; Lorusso, Domenica; Raspagliesi, Francesco.
In: Minerva Ginecologica, Vol. 68, No. 5, 01.10.2016, p. 536-543.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Risk-reducing surgery on the uterine adnexa
T2 - Timing and type of surgical treatment, and pathology report
AU - Signorelli, Mauro
AU - Bogani, Giorgio
AU - Ditto, Antonino
AU - Martinelli, Fabio
AU - Chiappa, Valentina
AU - Lopez, Carlos
AU - Scaffa, Cono
AU - Lorusso, Domenica
AU - Raspagliesi, Francesco
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Inherited mutations in BRCA1 and BRCA2 increase sigfincantly the risk of developing breast and ovarian cancers, and they have been associated with increased risks of developing other types of cancer. Although screening programs have been implemented in order to detect cancers at the early stage, they resulted ineffective. To date, risk-reducing bilateral salpingo-oophorectomy represents the only procedure allowing reducing the incidence of ovarian cancer and increasing survival among BRCA1 and -2 mutation carriers. In the present review we will discuss the advantages and disadvantages related to the execution of prophylactic surgery, thus underlying possible beneficial and detrimental effects of this kind of surgery in premenopausal women. Additionally, we will investigate further therapeutic strategies aimed to reduce the risk of developing ovarian cancer, without affected patients' hormonal status.
AB - Inherited mutations in BRCA1 and BRCA2 increase sigfincantly the risk of developing breast and ovarian cancers, and they have been associated with increased risks of developing other types of cancer. Although screening programs have been implemented in order to detect cancers at the early stage, they resulted ineffective. To date, risk-reducing bilateral salpingo-oophorectomy represents the only procedure allowing reducing the incidence of ovarian cancer and increasing survival among BRCA1 and -2 mutation carriers. In the present review we will discuss the advantages and disadvantages related to the execution of prophylactic surgery, thus underlying possible beneficial and detrimental effects of this kind of surgery in premenopausal women. Additionally, we will investigate further therapeutic strategies aimed to reduce the risk of developing ovarian cancer, without affected patients' hormonal status.
KW - BRCA1 gene
KW - BRCA2 gene
KW - Ovarian neoplasms
KW - Ovariectomy
KW - Prophylactic surgical procedures
UR - http://www.scopus.com/inward/record.url?scp=84983638441&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84983638441&partnerID=8YFLogxK
M3 - Review article
VL - 68
SP - 536
EP - 543
JO - Minerva Ginecologica
JF - Minerva Ginecologica
SN - 0026-4784
IS - 5
ER -