Risk-reducing surgery on the uterine adnexa

Timing and type of surgical treatment, and pathology report

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Inherited mutations in BRCA1 and BRCA2 increase sigfincantly the risk of developing breast and ovarian cancers, and they have been associated with increased risks of developing other types of cancer. Although screening programs have been implemented in order to detect cancers at the early stage, they resulted ineffective. To date, risk-reducing bilateral salpingo-oophorectomy represents the only procedure allowing reducing the incidence of ovarian cancer and increasing survival among BRCA1 and -2 mutation carriers. In the present review we will discuss the advantages and disadvantages related to the execution of prophylactic surgery, thus underlying possible beneficial and detrimental effects of this kind of surgery in premenopausal women. Additionally, we will investigate further therapeutic strategies aimed to reduce the risk of developing ovarian cancer, without affected patients' hormonal status.

Original languageEnglish
Pages (from-to)536-543
Number of pages8
JournalMinerva Ginecologica
Volume68
Issue number5
Publication statusPublished - Oct 1 2016

Fingerprint

Surgical Pathology
Ovarian Neoplasms
Mutation
Ovariectomy
Therapeutics
Neoplasms
Breast Neoplasms
Survival
Incidence

Keywords

  • BRCA1 gene
  • BRCA2 gene
  • Ovarian neoplasms
  • Ovariectomy
  • Prophylactic surgical procedures

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

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title = "Risk-reducing surgery on the uterine adnexa: Timing and type of surgical treatment, and pathology report",
abstract = "Inherited mutations in BRCA1 and BRCA2 increase sigfincantly the risk of developing breast and ovarian cancers, and they have been associated with increased risks of developing other types of cancer. Although screening programs have been implemented in order to detect cancers at the early stage, they resulted ineffective. To date, risk-reducing bilateral salpingo-oophorectomy represents the only procedure allowing reducing the incidence of ovarian cancer and increasing survival among BRCA1 and -2 mutation carriers. In the present review we will discuss the advantages and disadvantages related to the execution of prophylactic surgery, thus underlying possible beneficial and detrimental effects of this kind of surgery in premenopausal women. Additionally, we will investigate further therapeutic strategies aimed to reduce the risk of developing ovarian cancer, without affected patients' hormonal status.",
keywords = "BRCA1 gene, BRCA2 gene, Ovarian neoplasms, Ovariectomy, Prophylactic surgical procedures",
author = "Mauro Signorelli and Giorgio Bogani and Antonino Ditto and Fabio Martinelli and Valentina Chiappa and Carlos Lopez and Cono Scaffa and Domenica Lorusso and Francesco Raspagliesi",
year = "2016",
month = "10",
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language = "English",
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journal = "Minerva Ginecologica",
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publisher = "Edizioni Minerva Medica S.p.A.",
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TY - JOUR

T1 - Risk-reducing surgery on the uterine adnexa

T2 - Timing and type of surgical treatment, and pathology report

AU - Signorelli, Mauro

AU - Bogani, Giorgio

AU - Ditto, Antonino

AU - Martinelli, Fabio

AU - Chiappa, Valentina

AU - Lopez, Carlos

AU - Scaffa, Cono

AU - Lorusso, Domenica

AU - Raspagliesi, Francesco

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Inherited mutations in BRCA1 and BRCA2 increase sigfincantly the risk of developing breast and ovarian cancers, and they have been associated with increased risks of developing other types of cancer. Although screening programs have been implemented in order to detect cancers at the early stage, they resulted ineffective. To date, risk-reducing bilateral salpingo-oophorectomy represents the only procedure allowing reducing the incidence of ovarian cancer and increasing survival among BRCA1 and -2 mutation carriers. In the present review we will discuss the advantages and disadvantages related to the execution of prophylactic surgery, thus underlying possible beneficial and detrimental effects of this kind of surgery in premenopausal women. Additionally, we will investigate further therapeutic strategies aimed to reduce the risk of developing ovarian cancer, without affected patients' hormonal status.

AB - Inherited mutations in BRCA1 and BRCA2 increase sigfincantly the risk of developing breast and ovarian cancers, and they have been associated with increased risks of developing other types of cancer. Although screening programs have been implemented in order to detect cancers at the early stage, they resulted ineffective. To date, risk-reducing bilateral salpingo-oophorectomy represents the only procedure allowing reducing the incidence of ovarian cancer and increasing survival among BRCA1 and -2 mutation carriers. In the present review we will discuss the advantages and disadvantages related to the execution of prophylactic surgery, thus underlying possible beneficial and detrimental effects of this kind of surgery in premenopausal women. Additionally, we will investigate further therapeutic strategies aimed to reduce the risk of developing ovarian cancer, without affected patients' hormonal status.

KW - BRCA1 gene

KW - BRCA2 gene

KW - Ovarian neoplasms

KW - Ovariectomy

KW - Prophylactic surgical procedures

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VL - 68

SP - 536

EP - 543

JO - Minerva Ginecologica

JF - Minerva Ginecologica

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