Risperidone treatment of behavioral disturbances in outpatients with dementia

Michael C. Irizarry, S. Nassir Ghaemi, Erica R. Lee-Cherry, Teresa Gomez-Isla, Giuliano Binetti, Bradley T. Hyman, John H. Growdon

Research output: Contribution to journalArticlepeer-review


The authors retrospectively assessed the effectiveness and side effects of risperidone used to treat behavioral disturbances in elderly outpatients with dementia. In 41 patients treated with risperidone 1.8 ± 1.4 mg/day, there was complete suppression of the target symptom in 15%, partial response in 41%, and no response in 44%. Risperidone appeared equally effective in treating agitation and psychosis. New or worsening extra-pyramidal side effects (EPS) occurred in 32%, associated with longer duration of treatment and possibly with concomitant use of serotonergic anti-depressants. Risperidone was a useful adjunct in the treatment of agitation and psychosis in outpatients with dementia but was limited by EPS in about one-third of patients.

Original languageEnglish
Pages (from-to)336-342
Number of pages7
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number3
Publication statusPublished - Jun 1999

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)


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