Risperidone treatment of behavioral disturbances in outpatients with dementia

Michael C. Irizarry; S. Nassir Ghaemi; Erica R. Lee-Cherry; Teresa Gomez-Isla; Giuliano Binetti; Bradley T. Hyman; John H. Growdon

Risperidone treatment of behavioral disturbances in outpatients with dementia

Michael C. Irizarry, S. Nassir Ghaemi, Erica R. Lee-Cherry, Teresa Gomez-Isla, Giuliano Binetti, Bradley T. Hyman, John H. Growdon

Centro San Giovanni di Dio - Fatebenefratelli

Research output: Contribution to journal › Article › peer-review

Abstract

The authors retrospectively assessed the effectiveness and side effects of risperidone used to treat behavioral disturbances in elderly outpatients with dementia. In 41 patients treated with risperidone 1.8 ± 1.4 mg/day, there was complete suppression of the target symptom in 15%, partial response in 41%, and no response in 44%. Risperidone appeared equally effective in treating agitation and psychosis. New or worsening extra-pyramidal side effects (EPS) occurred in 32%, associated with longer duration of treatment and possibly with concomitant use of serotonergic anti-depressants. Risperidone was a useful adjunct in the treatment of agitation and psychosis in outpatients with dementia but was limited by EPS in about one-third of patients.

Original language	English
Pages (from-to)	336-342
Number of pages	7
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	11
Issue number	3
Publication status	Published - Jun 1999

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Neuroscience(all)

Cite this

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title = "Risperidone treatment of behavioral disturbances in outpatients with dementia",

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AU - Irizarry, Michael C.

AU - Ghaemi, S. Nassir

AU - Lee-Cherry, Erica R.

AU - Gomez-Isla, Teresa

AU - Binetti, Giuliano

AU - Hyman, Bradley T.

AU - Growdon, John H.

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N2 - The authors retrospectively assessed the effectiveness and side effects of risperidone used to treat behavioral disturbances in elderly outpatients with dementia. In 41 patients treated with risperidone 1.8 ± 1.4 mg/day, there was complete suppression of the target symptom in 15%, partial response in 41%, and no response in 44%. Risperidone appeared equally effective in treating agitation and psychosis. New or worsening extra-pyramidal side effects (EPS) occurred in 32%, associated with longer duration of treatment and possibly with concomitant use of serotonergic anti-depressants. Risperidone was a useful adjunct in the treatment of agitation and psychosis in outpatients with dementia but was limited by EPS in about one-third of patients.

AB - The authors retrospectively assessed the effectiveness and side effects of risperidone used to treat behavioral disturbances in elderly outpatients with dementia. In 41 patients treated with risperidone 1.8 ± 1.4 mg/day, there was complete suppression of the target symptom in 15%, partial response in 41%, and no response in 44%. Risperidone appeared equally effective in treating agitation and psychosis. New or worsening extra-pyramidal side effects (EPS) occurred in 32%, associated with longer duration of treatment and possibly with concomitant use of serotonergic anti-depressants. Risperidone was a useful adjunct in the treatment of agitation and psychosis in outpatients with dementia but was limited by EPS in about one-third of patients.

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Risperidone treatment of behavioral disturbances in outpatients with dementia

Abstract

ASJC Scopus subject areas

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