Abstract
The discovery that apolipoprotein E (Apo E) ε4 allele is strongly linked to sporadic Alzheimer Disease (AD), raises the possibility that a dysfunction of the lipid transport system could be central in AD pathogenesis. The role of Apo E in the central nervous system is particularly important in relation to the cholinergic system, which relies on the integrity of phospholipid homeostasis in neurons. Recent evidence indicate that ε4 allele directly affect cholinergic activity in brain of AD subjects. These findings suggest that the isoform dosage of Apo E could be a prognostic indicator for the drug efficacy profile in the treatment of AD patients.
| Original language | Italian |
|---|---|
| Pages (from-to) | 79-84 |
| Number of pages | 6 |
| Journal | Giornale di Neuropsicofarmacologia |
| Volume | 23 |
| Issue number | 3-4 |
| Publication status | Published - 2001 |
ASJC Scopus subject areas
- Neuroscience(all)
- Pharmaceutical Science
- Pharmacology
- Neuropsychology and Physiological Psychology
Cite this
Risposta farmacologica nella malattia di Alzheimer : Possibile ruolo della apolipoproteina E. / Borroni, B.; Colciaghi, F.; Corsini, P.; Akkawi, N.; Giubilei, F.; Bruno, G.; Lenzi, G. L.; Di Luca, M.; Padovani, A.
In: Giornale di Neuropsicofarmacologia, Vol. 23, No. 3-4, 2001, p. 79-84.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Risposta farmacologica nella malattia di Alzheimer
T2 - Possibile ruolo della apolipoproteina E
AU - Borroni, B.
AU - Colciaghi, F.
AU - Corsini, P.
AU - Akkawi, N.
AU - Giubilei, F.
AU - Bruno, G.
AU - Lenzi, G. L.
AU - Di Luca, M.
AU - Padovani, A.
PY - 2001
Y1 - 2001
N2 - The discovery that apolipoprotein E (Apo E) ε4 allele is strongly linked to sporadic Alzheimer Disease (AD), raises the possibility that a dysfunction of the lipid transport system could be central in AD pathogenesis. The role of Apo E in the central nervous system is particularly important in relation to the cholinergic system, which relies on the integrity of phospholipid homeostasis in neurons. Recent evidence indicate that ε4 allele directly affect cholinergic activity in brain of AD subjects. These findings suggest that the isoform dosage of Apo E could be a prognostic indicator for the drug efficacy profile in the treatment of AD patients.
AB - The discovery that apolipoprotein E (Apo E) ε4 allele is strongly linked to sporadic Alzheimer Disease (AD), raises the possibility that a dysfunction of the lipid transport system could be central in AD pathogenesis. The role of Apo E in the central nervous system is particularly important in relation to the cholinergic system, which relies on the integrity of phospholipid homeostasis in neurons. Recent evidence indicate that ε4 allele directly affect cholinergic activity in brain of AD subjects. These findings suggest that the isoform dosage of Apo E could be a prognostic indicator for the drug efficacy profile in the treatment of AD patients.
KW - Acetylcholinesterase inhibitors
KW - Alzheimer disease
KW - Apolipoprotein E
UR - http://www.scopus.com/inward/record.url?scp=0035610308&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035610308&partnerID=8YFLogxK
M3 - Articolo
AN - SCOPUS:0035610308
VL - 23
SP - 79
EP - 84
JO - Giornale di Neuropsicofarmacologia
JF - Giornale di Neuropsicofarmacologia
SN - 0391-9048
IS - 3-4
ER -