TY - JOUR
T1 - Rivastigmine for refractory REM behavior disorder in Mild Cognitive Impairment
AU - Brunetti, Valerio
AU - Losurdo, Anna
AU - Testani, Elisa
AU - Lapenta, Leonardo
AU - Mariotti, Paolo
AU - Marra, Camillo
AU - Rossini, Paolo Maria
AU - Marca, Giacomo Della
PY - 2014
Y1 - 2014
N2 - Background: Mild Cognitive Impairment (MCI) and REM Behavior Disorder (RBD) are both associated with a degeneration of ponto-medullary cholinergic pathways. Methods: We conducted a placebo-controlled, cross-over pilot trial of Rivastigmine (RVT) in 25 consecutive patients with MCI, who presented RBD refractory to conventional first-line treatments (melatonin up to 5 mg/day and clonazepam up to 2 mg/day). Results: RVT treatment was followed by a significant reduction of RBD episodes when compared with placebo. Conclusions: Our data suggest that, in MCI patients with RBD resistant to conventional therapies (muscle relaxants benzodiazepines or melatonin,) treatment with RVT may induce a reduction in the frequency of RBD episodes compared to placebo.
AB - Background: Mild Cognitive Impairment (MCI) and REM Behavior Disorder (RBD) are both associated with a degeneration of ponto-medullary cholinergic pathways. Methods: We conducted a placebo-controlled, cross-over pilot trial of Rivastigmine (RVT) in 25 consecutive patients with MCI, who presented RBD refractory to conventional first-line treatments (melatonin up to 5 mg/day and clonazepam up to 2 mg/day). Results: RVT treatment was followed by a significant reduction of RBD episodes when compared with placebo. Conclusions: Our data suggest that, in MCI patients with RBD resistant to conventional therapies (muscle relaxants benzodiazepines or melatonin,) treatment with RVT may induce a reduction in the frequency of RBD episodes compared to placebo.
KW - Acetylcholine
KW - Acetylcholinesterase inhibitors
KW - Alzheimer disease
KW - Cholinergic pathways
KW - MCI
KW - Mild cognitive impairment
KW - RBD
KW - REM
KW - REM behavior disorder
KW - Rivastigmine (RVT)
KW - Sleep
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U2 - 10.2174/1567205011666140302195648
DO - 10.2174/1567205011666140302195648
M3 - Article
C2 - 24597506
AN - SCOPUS:84897404975
VL - 11
SP - 267
EP - 273
JO - Current Alzheimer Research
JF - Current Alzheimer Research
SN - 1567-2050
IS - 3
ER -