TY - JOUR
T1 - Rizatriptan in migraineurs with unilateral cranial autonomic symptoms
T2 - A double-blind trial
AU - Barbanti, Piero
AU - Fofi, Luisa
AU - Dall'Armi, Valentina
AU - Aurilia, Cinzia
AU - Egeo, Gabriella
AU - Vanacore, Nicola
AU - Bonassi, Stefano
PY - 2012/7
Y1 - 2012/7
N2 - The objective and background is to confirm in a double-blind, placebo-controlled study the high triptan response rates we had previously reported in an open study in migraine patients with unilateral cranial autonomic symptoms. In this randomized, double-blind, placebocontrolled study 80 migraineurs with unilateral cranial autonomic symptoms were assigned to receive rizatriptan 10 mg wafer or placebo (ratio 1:1) and treated for a single moderate or severe migraine attack. The primary endpoints were pain freedom at 2 h and total migraine freedom at 2 h. Secondary endpoints included pain relief, no associated symptoms and sustained pain freedom or relief. Significantly more patients reported pain freedom at 2 h after taking rizatriptan (54 %) than after placebo (8 %) (therapeutic gain 46 % [28 %; 64 %]; P
AB - The objective and background is to confirm in a double-blind, placebo-controlled study the high triptan response rates we had previously reported in an open study in migraine patients with unilateral cranial autonomic symptoms. In this randomized, double-blind, placebocontrolled study 80 migraineurs with unilateral cranial autonomic symptoms were assigned to receive rizatriptan 10 mg wafer or placebo (ratio 1:1) and treated for a single moderate or severe migraine attack. The primary endpoints were pain freedom at 2 h and total migraine freedom at 2 h. Secondary endpoints included pain relief, no associated symptoms and sustained pain freedom or relief. Significantly more patients reported pain freedom at 2 h after taking rizatriptan (54 %) than after placebo (8 %) (therapeutic gain 46 % [28 %; 64 %]; P
KW - Cranial autonomic symptoms
KW - Migraine
KW - Rizatriptan
KW - Treatment
KW - Trigemino-autonomic reflex
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U2 - 10.1007/s10194-012-0440-y
DO - 10.1007/s10194-012-0440-y
M3 - Article
C2 - 22460943
AN - SCOPUS:84865359500
VL - 13
SP - 407
EP - 414
JO - Journal of Headache and Pain
JF - Journal of Headache and Pain
SN - 1129-2369
IS - 5
ER -