RNA III inhibiting peptide inhibits in vivo biofilm formation by drug-resistant Staphylococcus aureus

Andrea Giacometti, Oscar Cirioni, Yael Gov, Roberto Ghiselli, Maria Simona Del Prete, Federico Mocchegiani, Vittorio Saba, Fiorenza Orlando, Giorgio Scalise, Naomi Balaban, Giorgio Dell'Acqua

Research output: Contribution to journalArticlepeer-review

Abstract

Staphylococcus aureus is a prevalent cause of bacterial infections associated with indwelling medical devices. RNA III inhibiting peptide (RIP) is known to inhibit S. aureus pathogenesis by disrupting quorum-sensing mechanisms. RIP was tested in the present study for its ability to inhibit S. aureus biofilm formation in a rat Dacron graft model. The activity of RIP was synergistic with those of antibiotics for the complete prevention of drug-resistant S. aureus infections.

Original languageEnglish
Pages (from-to)1979-1983
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume47
Issue number6
DOIs
Publication statusPublished - Jun 1 2003

ASJC Scopus subject areas

  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'RNA III inhibiting peptide inhibits in vivo biofilm formation by drug-resistant Staphylococcus aureus'. Together they form a unique fingerprint.

Cite this