RNA in amplification of the immunological response

G. Cavallo, G. Form, L. Varesio

Research output: Contribution to journalArticlepeer-review


The importance of RNA in the immune response has been widely demonstrated in the literature. A model showing that the primary response is the result of the following three steps is proposed. (1) Lymphocyte derepression mediated by the antigen and its differentiation into a plasma cell. (2) Intracellular amplification, i.e. a mechanism that tends to enhance immunoglobulin synthesis in antibody-forming cells selected and activated by the antigen. (3) Intercellular amplification, i.e. transfer of this ability to synthesize to other lymphoid cells that are not related to the immunogen, resulting in the involvement of a much larger quota of the lymphocyte population in the response to the antigen.

Original languageEnglish
Pages (from-to)383-392
Number of pages10
JournalJournal of Theoretical Biology
Issue number2
Publication statusPublished - 1975

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)


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