RNA interference as a tool for Alzheimer's disease therapy

Antonio Orlacchio, Giorgio Bernardi, Aldo Orlacchio, Sabata Martino

Research output: Contribution to journalArticlepeer-review

Abstract

RNA interference is a biological process that controls gene silencing in all living cells. Targeting the RNA interference system represents a novel therapeutic strategy able to intercede with multiple disease-related genes and to target many neurodegencrative diseases. Recently, the design of small interfering RNA-selective compounds has become more straightforward because of the significant progress made in predictive modeling for new therapeutic approaches. Although in vivo delivery of RNA interference remains a significant obstacle, new data show that RNAi blocks gene function in vivo, suggesting a potential therapeutic approach for humans. Some groups have demonstrated the efficacy of RNAi therapy in Alzheimer's disease. Results, based on animal models, show a down-regulation of the amyloid precursor protein and a consequent reduction of the amyloid-β peptide accumulation in the brain or the inactivation of P-secretase (BACEI). Indeed, lentiviral vectors expressing siRNAs targeting BACE1 reduce amyloid production and the neurodegencrative and behavioural deficit in APP transgenic mice. This review highlights recent advances in RNA research and focuses on strengths and weaknesses of RNAi compounds in Alzheimer's disease.

Original languageEnglish
Pages (from-to)1166-1176
Number of pages11
JournalMini-Reviews in Medicinal Chemistry
Volume7
Issue number11
DOIs
Publication statusPublished - Nov 2007

ASJC Scopus subject areas

  • Chemistry(all)
  • Medicine (miscellaneous)
  • Pharmacology

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