RNA modifications and human diseases

Federica Galeano; Angela Gallo

doi:10.1016/S1751-7222(08)70003-9

RNA modifications and human diseases

Federica Galeano, Angela Gallo

Ospedale Pediatrico Bambino Gesu

Research output: Contribution to journal › Article › peer-review

Abstract

Abstract: In eukaryotes mRNA transcripts are extensively processed by different post-transcriptional events such as alternative splicing and RNA editing in order to generate many different mRNAs from the same gene. Alternative splicing is a well recognized biological event for generating protein diversity, however RNA editing is less well known. The most common type of RNA editing in vertebrates and invertebrates is the conversion of specific adenosines to inosines within the RNA molecules by the ADAR family of enzymes.

Original language	English
Journal	Paediatrics and Child Health
Volume	18
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1016/S1751-7222(08)70003-9
Publication status	Published - Oct 2008

Keywords

ADAR
CNS
GluR-B
RNA editing

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

Access to Document

10.1016/S1751-7222(08)70003-9

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AB - Abstract: In eukaryotes mRNA transcripts are extensively processed by different post-transcriptional events such as alternative splicing and RNA editing in order to generate many different mRNAs from the same gene. Alternative splicing is a well recognized biological event for generating protein diversity, however RNA editing is less well known. The most common type of RNA editing in vertebrates and invertebrates is the conversion of specific adenosines to inosines within the RNA molecules by the ADAR family of enzymes.

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KW - GluR-B

KW - RNA editing

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