RNA modifications and human diseases

Federica Galeano, Angela Gallo

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract: In eukaryotes mRNA transcripts are extensively processed by different post-transcriptional events such as alternative splicing and RNA editing in order to generate many different mRNAs from the same gene. Alternative splicing is a well recognized biological event for generating protein diversity, however RNA editing is less well known. The most common type of RNA editing in vertebrates and invertebrates is the conversion of specific adenosines to inosines within the RNA molecules by the ADAR family of enzymes.

Original languageEnglish
JournalPaediatrics and Child Health
Volume18
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Oct 2008

Keywords

  • ADAR
  • CNS
  • GluR-B
  • RNA editing

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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