Abstract
Coding and long non-coding RNA (lncRNA) metabolism is now revealing its crucial role in Amyotrophic Lateral Sclerosis (ALS) pathogenesis. In this work, we present a dataset obtained via Illumina RNA-seq analysis on Peripheral Blood Mononuclear Cells (PBMCs) from sporadic and mutated ALS patients (mutations in FUS, TARDBP, SOD1 and VCP genes) and healthy controls. This dataset allows the whole-transcriptome characterization of PBMCs content, both in terms of coding and non-coding RNAs, in order to compare the disease state to the healthy controls, both for sporadic patients and for mutated patients. Our dataset is a starting point for the omni-comprehensive analysis of coding and lncRNAs, from an easy to withdraw, manage and store tissue that shows to be a suitable model for RNA profiling in ALS.
| Original language | English |
|---|---|
| Pages (from-to) | 190006 |
| Journal | Scientific data |
| Volume | 6 |
| DOIs | |
| Publication status | Published - Feb 5 2019 |
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RNA-Seq profiling in peripheral blood mononuclear cells of amyotrophic lateral sclerosis patients and controls. / Zucca, Susanna; Gagliardi, Stella; Pandini, Cecilia; Diamanti, Luca; Bordoni, Matteo; Sproviero, Daisy; Arigoni, Maddalena; Olivero, Martina; Pansarasa, Orietta; Ceroni, Mauro; Calogero, Raffaele; Cereda, Cristina.
In: Scientific data, Vol. 6, 05.02.2019, p. 190006.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - RNA-Seq profiling in peripheral blood mononuclear cells of amyotrophic lateral sclerosis patients and controls
AU - Zucca, Susanna
AU - Gagliardi, Stella
AU - Pandini, Cecilia
AU - Diamanti, Luca
AU - Bordoni, Matteo
AU - Sproviero, Daisy
AU - Arigoni, Maddalena
AU - Olivero, Martina
AU - Pansarasa, Orietta
AU - Ceroni, Mauro
AU - Calogero, Raffaele
AU - Cereda, Cristina
PY - 2019/2/5
Y1 - 2019/2/5
N2 - Coding and long non-coding RNA (lncRNA) metabolism is now revealing its crucial role in Amyotrophic Lateral Sclerosis (ALS) pathogenesis. In this work, we present a dataset obtained via Illumina RNA-seq analysis on Peripheral Blood Mononuclear Cells (PBMCs) from sporadic and mutated ALS patients (mutations in FUS, TARDBP, SOD1 and VCP genes) and healthy controls. This dataset allows the whole-transcriptome characterization of PBMCs content, both in terms of coding and non-coding RNAs, in order to compare the disease state to the healthy controls, both for sporadic patients and for mutated patients. Our dataset is a starting point for the omni-comprehensive analysis of coding and lncRNAs, from an easy to withdraw, manage and store tissue that shows to be a suitable model for RNA profiling in ALS.
AB - Coding and long non-coding RNA (lncRNA) metabolism is now revealing its crucial role in Amyotrophic Lateral Sclerosis (ALS) pathogenesis. In this work, we present a dataset obtained via Illumina RNA-seq analysis on Peripheral Blood Mononuclear Cells (PBMCs) from sporadic and mutated ALS patients (mutations in FUS, TARDBP, SOD1 and VCP genes) and healthy controls. This dataset allows the whole-transcriptome characterization of PBMCs content, both in terms of coding and non-coding RNAs, in order to compare the disease state to the healthy controls, both for sporadic patients and for mutated patients. Our dataset is a starting point for the omni-comprehensive analysis of coding and lncRNAs, from an easy to withdraw, manage and store tissue that shows to be a suitable model for RNA profiling in ALS.
U2 - 10.1038/sdata.2019.6
DO - 10.1038/sdata.2019.6
M3 - Article
C2 - 30720798
VL - 6
SP - 190006
JO - Scientific data
JF - Scientific data
SN - 2052-4463
ER -