RNAIII-inhibiting peptide affects biofilm formation in a rat model of staphylococcal ureteral stent infection

Oscar Cirioni, Roberto Ghiselli, Daniele Minardi, Fiorenza Orlando, Federico Mocchegiani, Carmela Silvestri, Giovanni Muzzonigro, Vittorio Saba, Giorgio Scalise, Naomi Balaban, Andrea Giacometti

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Ureteral stents coated with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rat bladders and shown to suppress Staphylococcus aureus formation on the stent and in urine and was especially effective when combined with teicoplanin. Coating ureteral stents with RIP thus increases the efficacy of teicoplanin in preventing ureteral stent-associated staphylococcal infections.

Original languageEnglish
Pages (from-to)4518-4520
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume51
Issue number12
DOIs
Publication statusPublished - Dec 2007

Fingerprint

Biofilms
Stents
Teicoplanin
Infection
Staphylococcal Infections
Quorum Sensing
Staphylococcus aureus
Urinary Bladder
Urine
RNAIII inhibiting peptide

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

RNAIII-inhibiting peptide affects biofilm formation in a rat model of staphylococcal ureteral stent infection. / Cirioni, Oscar; Ghiselli, Roberto; Minardi, Daniele; Orlando, Fiorenza; Mocchegiani, Federico; Silvestri, Carmela; Muzzonigro, Giovanni; Saba, Vittorio; Scalise, Giorgio; Balaban, Naomi; Giacometti, Andrea.

In: Antimicrobial Agents and Chemotherapy, Vol. 51, No. 12, 12.2007, p. 4518-4520.

Research output: Contribution to journalArticle

Cirioni, O, Ghiselli, R, Minardi, D, Orlando, F, Mocchegiani, F, Silvestri, C, Muzzonigro, G, Saba, V, Scalise, G, Balaban, N & Giacometti, A 2007, 'RNAIII-inhibiting peptide affects biofilm formation in a rat model of staphylococcal ureteral stent infection', Antimicrobial Agents and Chemotherapy, vol. 51, no. 12, pp. 4518-4520. https://doi.org/10.1128/AAC.00808-07
Cirioni, Oscar ; Ghiselli, Roberto ; Minardi, Daniele ; Orlando, Fiorenza ; Mocchegiani, Federico ; Silvestri, Carmela ; Muzzonigro, Giovanni ; Saba, Vittorio ; Scalise, Giorgio ; Balaban, Naomi ; Giacometti, Andrea. / RNAIII-inhibiting peptide affects biofilm formation in a rat model of staphylococcal ureteral stent infection. In: Antimicrobial Agents and Chemotherapy. 2007 ; Vol. 51, No. 12. pp. 4518-4520.
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