Abstract
The RNASET2 gene, mapped in 6q27, was previously found to exert control of tumorigenesis in an ovarian cancer system. We present here results indicating a similar control in a melanoma cancer model. Thus, this gene is most likely involved in a common general pathway of tumorigenesis. Moreover, its antitumorigenic activity is manifested in vivo but not in vitro, suggesting that this gene belongs to the growing category of tumor antagonizing/malignancy suppressor genes. A possible role of RNASET2 in the activation of a senescence program, whose responsible locus was mapped in the same chromosomal 6q27 region, seems to be inconsistent with our data.
| Original language | English |
|---|---|
| Pages (from-to) | 69-74 |
| Number of pages | 6 |
| Journal | Oncology Research |
| Volume | 17 |
| Issue number | 2 |
| Publication status | Published - 2008 |
Keywords
- Antitumorigenic activity tumor suppressor gene
- Melanoma model
- RNASET2
ASJC Scopus subject areas
- Cancer Research
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Monti, L., Rudolfo, M., Lo Russo, G., Noonan, D., Acquati, F., & Taramelli, R. (2008). RNASET2 as a tumor antagonizing gene in a melanoma cancer model. Oncology Research, 17(2), 69-74.