RNASET2 as a tumor antagonizing gene in a melanoma cancer model

Laura Monti, Monica Rudolfo, Girieca Lo Russo, Douglas Noonan, Francesco Acquati, Roberto Taramelli

Research output: Contribution to journalArticle

Abstract

The RNASET2 gene, mapped in 6q27, was previously found to exert control of tumorigenesis in an ovarian cancer system. We present here results indicating a similar control in a melanoma cancer model. Thus, this gene is most likely involved in a common general pathway of tumorigenesis. Moreover, its antitumorigenic activity is manifested in vivo but not in vitro, suggesting that this gene belongs to the growing category of tumor antagonizing/malignancy suppressor genes. A possible role of RNASET2 in the activation of a senescence program, whose responsible locus was mapped in the same chromosomal 6q27 region, seems to be inconsistent with our data.

Original languageEnglish
Pages (from-to)69-74
Number of pages6
JournalOncology Research
Volume17
Issue number2
Publication statusPublished - 2008

Keywords

  • Antitumorigenic activity tumor suppressor gene
  • Melanoma model
  • RNASET2

ASJC Scopus subject areas

  • Cancer Research

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  • Cite this

    Monti, L., Rudolfo, M., Lo Russo, G., Noonan, D., Acquati, F., & Taramelli, R. (2008). RNASET2 as a tumor antagonizing gene in a melanoma cancer model. Oncology Research, 17(2), 69-74.