Robot-Assisted Stereotactic Biopsy of Diffuse Intrinsic Pontine Glioma: A Single-Center Experience

Andrea Carai, Angela Mastronuzzi, Alessandro De Benedictis, Raffaella Messina, Antonella Cacchione, Evelina Miele, Franco Randi, Giacomo Esposito, Andrea Trezza, Giovanna Stefania Colafati, Alessandra Savioli, Franco Locatelli, Carlo Efisio Marras

Research output: Contribution to journalArticlepeer-review


Background Diffuse intrinsic pontine glioma (DIPG) is a childhood tumor with a dismal prognosis. Emerging molecular signatures have paved the way for stereotactic biopsy in selected centers. We present our experience in DIPG stereotactic needle biopsy using the Robotic Stereotactic-Assisted system (ROSA) in a series of consecutive pediatric patients. Methods All stereotactic biopsy procedures for DIPG performed during the last year at our institution were considered. All procedures were carried out using the ROSA surgical assistant through a precoronary approach. All children underwent a postoperative computed tomography scan to document possible surgical complications and confirm the site of biopsy. Postoperative clinical changes were recorded to test morbidity of the procedure. Results In the last year, we performed 7 pontine needle biopsies. Specimens were diagnostic and useful for molecular analysis in all cases. No surgical complications were observed. One child showed a transient neurologic worsening related to the biopsy that resolved within 2 weeks. The combination of the precoronary approach and use of the stereotactic ROSA system allowed single-session surgeries in all cases. Conclusions Pontine biopsy for DIPG is a safe procedure in selected centers. The advantages of the single-session procedure we described might be of particular interest in the pediatric setting.

Original languageEnglish
Pages (from-to)584-588
Number of pages5
JournalWorld Neurosurgery
Publication statusPublished - May 1 2017


  • Biopsy
  • Brainstem
  • DIPG
  • Pediatric brain tumor
  • Stereotactic

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


Dive into the research topics of 'Robot-Assisted Stereotactic Biopsy of Diffuse Intrinsic Pontine Glioma: A Single-Center Experience'. Together they form a unique fingerprint.

Cite this