Abstract
Background Diffuse intrinsic pontine glioma (DIPG) is a childhood tumor with a dismal prognosis. Emerging molecular signatures have paved the way for stereotactic biopsy in selected centers. We present our experience in DIPG stereotactic needle biopsy using the Robotic Stereotactic-Assisted system (ROSA) in a series of consecutive pediatric patients. Methods All stereotactic biopsy procedures for DIPG performed during the last year at our institution were considered. All procedures were carried out using the ROSA surgical assistant through a precoronary approach. All children underwent a postoperative computed tomography scan to document possible surgical complications and confirm the site of biopsy. Postoperative clinical changes were recorded to test morbidity of the procedure. Results In the last year, we performed 7 pontine needle biopsies. Specimens were diagnostic and useful for molecular analysis in all cases. No surgical complications were observed. One child showed a transient neurologic worsening related to the biopsy that resolved within 2 weeks. The combination of the precoronary approach and use of the stereotactic ROSA system allowed single-session surgeries in all cases. Conclusions Pontine biopsy for DIPG is a safe procedure in selected centers. The advantages of the single-session procedure we described might be of particular interest in the pediatric setting.
| Original language | English |
|---|---|
| Pages (from-to) | 584-588 |
| Number of pages | 5 |
| Journal | World Neurosurgery |
| Volume | 101 |
| DOIs | |
| Publication status | Published - May 1 2017 |
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Keywords
- Biopsy
- Brainstem
- DIPG
- Pediatric brain tumor
- Stereotactic
ASJC Scopus subject areas
- Surgery
- Clinical Neurology
Cite this
Robot-Assisted Stereotactic Biopsy of Diffuse Intrinsic Pontine Glioma : A Single-Center Experience. / Carai, Andrea; Mastronuzzi, Angela; De Benedictis, Alessandro; Messina, Raffaella; Cacchione, Antonella; Miele, Evelina; Randi, Franco; Esposito, Giacomo; Trezza, Andrea; Colafati, Giovanna Stefania; Savioli, Alessandra; Locatelli, Franco; Marras, Carlo Efisio.
In: World Neurosurgery, Vol. 101, 01.05.2017, p. 584-588.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Robot-Assisted Stereotactic Biopsy of Diffuse Intrinsic Pontine Glioma
T2 - A Single-Center Experience
AU - Carai, Andrea
AU - Mastronuzzi, Angela
AU - De Benedictis, Alessandro
AU - Messina, Raffaella
AU - Cacchione, Antonella
AU - Miele, Evelina
AU - Randi, Franco
AU - Esposito, Giacomo
AU - Trezza, Andrea
AU - Colafati, Giovanna Stefania
AU - Savioli, Alessandra
AU - Locatelli, Franco
AU - Marras, Carlo Efisio
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Background Diffuse intrinsic pontine glioma (DIPG) is a childhood tumor with a dismal prognosis. Emerging molecular signatures have paved the way for stereotactic biopsy in selected centers. We present our experience in DIPG stereotactic needle biopsy using the Robotic Stereotactic-Assisted system (ROSA) in a series of consecutive pediatric patients. Methods All stereotactic biopsy procedures for DIPG performed during the last year at our institution were considered. All procedures were carried out using the ROSA surgical assistant through a precoronary approach. All children underwent a postoperative computed tomography scan to document possible surgical complications and confirm the site of biopsy. Postoperative clinical changes were recorded to test morbidity of the procedure. Results In the last year, we performed 7 pontine needle biopsies. Specimens were diagnostic and useful for molecular analysis in all cases. No surgical complications were observed. One child showed a transient neurologic worsening related to the biopsy that resolved within 2 weeks. The combination of the precoronary approach and use of the stereotactic ROSA system allowed single-session surgeries in all cases. Conclusions Pontine biopsy for DIPG is a safe procedure in selected centers. The advantages of the single-session procedure we described might be of particular interest in the pediatric setting.
AB - Background Diffuse intrinsic pontine glioma (DIPG) is a childhood tumor with a dismal prognosis. Emerging molecular signatures have paved the way for stereotactic biopsy in selected centers. We present our experience in DIPG stereotactic needle biopsy using the Robotic Stereotactic-Assisted system (ROSA) in a series of consecutive pediatric patients. Methods All stereotactic biopsy procedures for DIPG performed during the last year at our institution were considered. All procedures were carried out using the ROSA surgical assistant through a precoronary approach. All children underwent a postoperative computed tomography scan to document possible surgical complications and confirm the site of biopsy. Postoperative clinical changes were recorded to test morbidity of the procedure. Results In the last year, we performed 7 pontine needle biopsies. Specimens were diagnostic and useful for molecular analysis in all cases. No surgical complications were observed. One child showed a transient neurologic worsening related to the biopsy that resolved within 2 weeks. The combination of the precoronary approach and use of the stereotactic ROSA system allowed single-session surgeries in all cases. Conclusions Pontine biopsy for DIPG is a safe procedure in selected centers. The advantages of the single-session procedure we described might be of particular interest in the pediatric setting.
KW - Biopsy
KW - Brainstem
KW - DIPG
KW - Pediatric brain tumor
KW - Stereotactic
UR - http://www.scopus.com/inward/record.url?scp=85016390579&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85016390579&partnerID=8YFLogxK
U2 - 10.1016/j.wneu.2017.02.088
DO - 10.1016/j.wneu.2017.02.088
M3 - Article
C2 - 28254596
AN - SCOPUS:85016390579
VL - 101
SP - 584
EP - 588
JO - World Neurosurgery
JF - World Neurosurgery
SN - 1878-8750
ER -